Imperial College London

Professor Dan Elson

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Surgical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 1700daniel.elson Website

 
 
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Location

 

415 Bessemer BuildingBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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373 results found

Brunckhorst O, Ong QJ, Elson D, Mayer Eet al., 2019, Novel real-time optical imaging modalities for the detection of neoplastic lesions in urology: a systematic review., Surg Endosc, Vol: 33, Pages: 1349-1367

BACKGROUND: Current optical diagnostic techniques for malignancies are limited in their diagnostic accuracy and lack the ability to further characterise disease, leading to the rapidly increasing development of novel imaging methods within urology. This systematic review critically appraises the literature for novel imagining modalities, in the detection and staging of urological cancer and assesses their effectiveness via their utility and accuracy. METHODS: A systematic literature search utilising MEDLINE, EMBASE and Cochrane Library Database was conducted from 1970 to September 2018 by two independent reviewers. Studies were included if they assessed real-time imaging modalities not already approved in guidelines, in vivo and in humans. Outcome measures included diagnostic accuracy and utility parameters, including feasibility and cost. RESULTS: Of 5475 articles identified from screening, a final 46 were included. Imaging modalities for bladder cancer included optical coherence tomography (OCT), confocal laser endomicroscopy, autofluorescence and spectroscopic techniques. OCT was the most widely investigated, with 12 studies demonstrating improvements in overall diagnostic accuracy (sensitivity 74.5-100% and specificity 60-98.5%). Upper urinary tract malignancy diagnosis was assessed using photodynamic diagnosis (PDD), narrow band imaging, optical coherence tomography and confocal laser endomicroscopy. Only PDD demonstrated consistent improvements in overall diagnostic accuracy in five trials (sensitivity 94-96% and specificity 96.6-100%). Limited evidence for optical coherence tomography in percutaneous renal biopsy was identified, with anecdotal evidence for any modality in penile cancer. CONCLUSIONS: Evidence supporting the efficacy for identified novel imaging modalities remains limited at present. However, OCT for bladder cancer and PDD in upper tract malignancy demonstrate the best potential for improvement in overall diagnostic accuracy. OCT may additional

JOURNAL ARTICLE

Lin J, Walsted ES, Backer V, Hull JH, Elson DSet al., 2019, Quantification and Analysis of Laryngeal Closure From Endoscopic Videos, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 66, Pages: 1127-1136, ISSN: 0018-9294

JOURNAL ARTICLE

Sheng W, Li W, Qi J, Liu T, He H, Dong Y, Liu S, Wu J, Elson DS, Ma Het al., 2019, Quantitative Analysis of 4 x 4 Mueller Matrix Transformation Parameters for Biomedical Imaging, PHOTONICS, Vol: 6, ISSN: 2304-6732

JOURNAL ARTICLE

Li Q, Lin J, Clancy NT, Elson DSet al., 2019, Estimation of tissue oxygen saturation from RGB images and sparse hyperspectral signals based on conditional generative adversarial network., Int J Comput Assist Radiol Surg

PURPOSE: Intra-operative measurement of tissue oxygen saturation ([Formula: see text]) is important in detection of ischaemia, monitoring perfusion and identifying disease. Hyperspectral imaging (HSI) measures the optical reflectance spectrum of the tissue and uses this information to quantify its composition, including [Formula: see text]. However, real-time monitoring is difficult due to capture rate and data processing time. METHODS: An endoscopic system based on a multi-fibre probe was previously developed to sparsely capture HSI data (sHSI). These were combined with RGB images, via a deep neural network, to generate high-resolution hypercubes and calculate [Formula: see text]. To improve accuracy and processing speed, we propose a dual-input conditional generative adversarial network, Dual2StO2, to directly estimate [Formula: see text] by fusing features from both RGB and sHSI. RESULTS: Validation experiments were carried out on in vivo porcine bowel data, where the ground truth [Formula: see text] was generated from the HSI camera. Performance was also compared to our previous super-spectral-resolution network, SSRNet in terms of mean [Formula: see text] prediction accuracy and structural similarity metrics. Dual2StO2 was also tested using simulated probe data with varying fibre number. CONCLUSIONS: [Formula: see text] estimation by Dual2StO2 is visually closer to ground truth in general structure and achieves higher prediction accuracy and faster processing speed than SSRNet. Simulations showed that results improved when a greater number of fibres are used in the probe. Future work will include refinement of the network architecture, hardware optimization based on simulation results, and evaluation of the technique in clinical applications beyond [Formula: see text] estimation.

JOURNAL ARTICLE

Singh M, Nabavi E, Zhou Y, Gallina ME, Zhao H, Ruenraroengsak P, Porter AE, Ma D, Cass AEG, Hanna GB, Elson DSet al., 2019, Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment., Nanotheranostics, Vol: 3, Pages: 89-102

Endoscopy is the gold standard investigation in the diagnosis of gastrointestinal cancers and the management of early and pre-malignant lesions either by resection or ablation. Recently gold nanoparticles have shown promise in cancer diagnosis and therapeutics (theranostics). The combination of multifunctional gold nanoparticles with near infrared fluorescence endoscopy for accurate mapping of early or pre-malignant lesions can potentially enhance diagnostic efficiency while precisely directing endoscopic near infrared photothermal therapy for established cancers. The integration of endoscopy with near infrared fluorescence imaging and photothermal therapy was aided by the accumulation of our multifunctionalized PEG-GNR-Cy5.5-anti-EGFR-antibody gold nanorods within gastrointestinal tumor xenografts in BALB/c mice. Control mice (with tumors) received either gold nanorods or photothermal therapy, while study mice received both treatment modalities. Local (tumor-centric) and systemic effects were examined for 30 days. Clear endoscopic near infrared fluorescence signals were observed emanating specifically from tumor sites and these corresponded precisely to the tumor margins. Endoscopic fluorescence-guided near infrared photothermal therapy successfully induced tumor ablations in all 20 mice studied, with complete histological clearance and minimal collateral damage. Multi-source analysis from histology, electron microscopy, mass spectrometry, blood, clinical evaluation, psychosocial and weight monitoring demonstrated the inherent safety of this technology. The combination of this innovative nanotechnology with gold standard clinical practice will be of value in enhancing the early optical detection of gastrointestinal cancers and a useful adjunct for its therapy.

JOURNAL ARTICLE

Waldock WJ, Avila-Rencoret FB, Tincknell LG, Murphy J, Elson DS, Peters CJet al., 2018, Augmented intraoperative surgical vision for the assessment of gastrointestinal cancer resection margins, 21st Annual Meeting of the Association-of-Upper-Gastrointestinal-Surgeons-of-Great-Britain-and-Ireland (AUGIS), Publisher: WILEY, Pages: 15-16, ISSN: 0007-1323

CONFERENCE PAPER

Elson DS, Cleary K, Dupont P, Merrifield R, Riviere Cet al., 2018, Medical Robotics, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 46, Pages: 1433-1436, ISSN: 0090-6964

JOURNAL ARTICLE

Walsted ES, Lin J, Elson DS, Hull JHet al., 2018, Objective quantification and analysis of laryngeal obstruction using deep learning algorithms, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Zhao T, Deng L, Wang W, Elson DS, Su Let al., 2018, Bayes' theorem-based binary algorithm for fast reference-less calibration of a multimode fiber, OPTICS EXPRESS, Vol: 26, Pages: 20368-20378, ISSN: 1094-4087

JOURNAL ARTICLE

Lin J, Clancy NT, Qi J, Hu Y, Tatla T, Stoyanov D, Maier-Hein L, Elson DSet al., 2018, Dual-modality endoscopic probe for tissue surface shape reconstruction and hyperspectral imaging enabled by deep neural networks, MEDICAL IMAGE ANALYSIS, Vol: 48, Pages: 162-176, ISSN: 1361-8415

JOURNAL ARTICLE

Saso S, Tziraki M, Clancy NT, Song L, Bracewell-Milnes T, Jones BP, Al-Memar M, Yazbek J, Thum M-Y, Sayasneh A, Bourne T, Smith JR, Elson DS, Ghaem-Maghami Set al., 2018, Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623

JOURNAL ARTICLE

Deng L, Yan JD, Elson DS, Su Let al., 2018, Characterization of an imaging multimode optical fiber using a digital micro-mirror device based single-beam system, OPTICS EXPRESS, Vol: 26, Pages: 18436-18447, ISSN: 1094-4087

JOURNAL ARTICLE

Qi J, He H, Lin J, Dong Y, Chen D, Ma H, Elson DSet al., 2018, Assessment of tissue polarimetric properties using Stokes polarimetric imaging with circularly polarized illumination, JOURNAL OF BIOPHOTONICS, Vol: 11, ISSN: 1864-063X

JOURNAL ARTICLE

Saso S, Clancy NT, Jones BP, Bracewell-Milnes T, Al-Memar M, Cannon EM, Ahluwalia S, Yazbek J, Thum M-Y, Bourne T, Elson DS, Smith JR, Ghaem-Maghami Set al., 2018, Use of biomedical photonics in gynecological surgery: a uterine transplantation model, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623

JOURNAL ARTICLE

Avila Rencoret FB, Mylonas GP, Elson D, Robotic Wide-Field Optical Biopsy Imaging For Flexible Endoscopy, 26th International Congress of the European Association for Endoscopic Surgery (EAES)

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna G, Elson Det al., Fluorescence image-guided photothermal therapy: Diagnosis and treatment of upper gastrointestinal cancer and beyond (prize winner), Global Surgery

CONFERENCE PAPER

Elson D, Tincknell L, Avila Rencoret F, Murphy J, Peters Cet al., Intraoperative hyperspectral circumferential resection margin assessment for gastrointestinal cancer surgery (second prize), Career in Surgery

CONFERENCE PAPER

Elson D, Polarization- and wavelength-resolved imaging with standard laparoscopes (invited), SPIE BiOS Molecular Guided Surgery

CONFERENCE PAPER

Leiloglou M, Qi J, Rees Whippey D, Curtis A, Price C, Copner N, Martin-Gonzalez P, Hanna G, Darzi A, Leff D, Elson Det al., Guiding Fluorescence-Augmented Imaging System for Breast Cancer Surgery, BMES Annual Meeting

CONFERENCE PAPER

Elson D, Avila Rencoret F, Mylonas G, Robotic Wide-Field Optical Biopsy Imaging for Flexible Endoscopy (Gerhard Buess Technology Award), 26th Annual International EAES Congress

CONFERENCE PAPER

Zhao M, Oude Vrielink T, Elson D, Mylonas Get al., Endoscopic TORS-CYCLOPS: A Novel Cable-driven Parallel Robot for Transoral Laser Surgery, 26th Annual International EAES Congress

CONFERENCE PAPER

Li Q, Zhou X, Lin J, Zheng J, Clancy N, Elson Det al., Estimation of Tissue Oxygen Saturation from RGB Images based on Pixel-level Image Translation, Hamlyn Symposium on Medical Robotics

CONFERENCE PAPER

Leiloglou M, Qi J, Rees Whippey D, Curtis A, Price C, Copner N, Martin-Gonzalez P, Hanna G, Darzi A, Leff D, Elson Det al., Guiding Fluorescence-Augmented Imaging System for Breast Cancer Surgery, EPSRC Image Guided Therapies Young Investigators

CONFERENCE PAPER

Bamber J, Shah A, Bush N, Costa M, Harris-Birtill D, Lin S, Singh M, Scienti O, Darabara D, Elson D, ter Haar G, Rivens I, Long N, Tang Met al., Photoacoustic imaging and contrast agents in cancer research, Leeds Microbubble Symposium

CONFERENCE PAPER

Waldock W, Avila Rencoret F, Tincknell L, Murphy J, Elson D, Peters Cet al., Augmented intraoperative surgical vision for the assessment of gastrointestinal cancer resection margins, London Surgery Symposium

CONFERENCE PAPER

Qi J, Elson D, Stoyanov D, An eigen value calibration method and optimization for 3×3 Mueller polarimeters, 3rd China Symposium on Polarimetry and Ellipsometry

CONFERENCE PAPER

Elson D, Colour polarization-resolved imaging with clinical endoscopes (plenary), 3rd China Symposium on Polarimetry and Ellipsometry

CONFERENCE PAPER

Elson D, Endoscopic technologies for surgical vision, IOP Optics in Clinical Practice IV

CONFERENCE PAPER

Avila-Rencoret FB, Mylonas GP, Elson DS, 2018, Robotic wide-field optical biopsy endoscopy

© OSA 2018. This paper describes a novel robotic framework for wide-field optical biopsy endoscopy, characterizes in vitro its spatial and spectral resolution, real time hyperspectral tissue classification, and demonstrates its feasibility on fresh porcine cadaveric colon.

CONFERENCE PAPER

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