Imperial College London

Professor Dan Elson

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Surgical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 1700daniel.elson Website

 
 
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Location

 

415 Bessemer BuildingBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

310 results found

Clancy NT, Elson DS, Teare J, 2017, Hyperspectral imaging of colonic polyps in vivo (Conference Presentation), Conference on Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Dong Y, Qi J, He H, He C, Liu S, Wu J, Elson DS, Ma Het al., 2017, Quantitatively characterizing the microstructural features of breast ductal carcinoma tissues in different progression stages by Mueller matrix microscope, BIOMEDICAL OPTICS EXPRESS, Vol: 8, Pages: 3643-3655, ISSN: 2156-7085

JOURNAL ARTICLE

Harris-Birtill D, Singh M, Zhou Y, Shah A, Ruenraroengsak P, Gallina ME, Hanna GB, Cass AEG, Porter AE, Bamber J, Elson DSet al., 2017, Gold nanorod reshaping in vitro and in vivo using a continuous wave laser., PLoS ONE, Vol: 12, ISSN: 1932-6203

Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical absorption spectral peak wavelength is determined by their size and shape. Photothermal therapy using GNRs is typically established using near infrared light as this allows sufficient penetration into the tumour matrix. Continuous wave (CW) lasers are the most commonly applied source of near infrared irradiation on GNRs for tumour photothermal therapy. It is perceived that large tumours may require fractionated or prolonged irradiation. However the true efficacy of repeated or protracted CW irradiation on tumour sites using the original sample of GNRs remains unclear. In this study spectroscopy and transmission electron microscopy are used to demonstrate that GNRs reshape both in vitro and in vivo after CW irradiation, which reduces their absorption efficiency. These changes were sustained throughout and beyond the initial period of irradiation, resulting from a spectral blue-shift and a considerable diminution in the absorption peak of GNRs. Solid subcutaneous tumours in immunodeficient BALB/c mice were subjected to GNRs and analysed with electron microscopy pre- and post-CW laser irradiation. This phenomenon of thermally induced GNR reshaping can occur at relatively low bulk temperatures, well below the bulk melting point of gold. Photoacoustic monitoring of GNR reshaping is also evaluated as a potential clinical aid to determine GNR absorption and reshaping during photothermal therapy. Aggregation of particles was coincidentally observed following CW irradiation, which would further diminish the subsequent optical absorption capacity of irradiated GNRs. It is thus established that sequential or prolonged applications of CW laser will not confer any additional photothermal effect on tumours due to significant attenuations in the peak optical absorpt

JOURNAL ARTICLE

Janatka M, Ramdoo KS, Tatla T, Pachtrachai K, Elson DS, Stoyanov Det al., 2017, Examining in vivo Tympanic Membrane Mobility Using Smart Phone Video-Otoscopy and Phase-based Eulerian Video Magnification, Conference on Medical Imaging - Computer-Aided Diagnosis, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Jones G, Clancy NT, Helo Y, Arridge S, Elson DS, Stoyanov Det al., 2017, Bayesian Estimation of Intrinsic Tissue Oxygenation and Perfusion From RGB Images, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 36, Pages: 1491-1501, ISSN: 0278-0062

JOURNAL ARTICLE

Ong ZY, Chen S, Nabavi E, Regoutz A, Payne DJ, Elson DS, Dexter DT, Dunlop LE, Porter AEet al., 2017, Multibranched Gold Nanoparticles with Intrinsic LAT-1 Targeting Capabilities for Selective Photothermal Therapy of Breast Cancer, ACS APPLIED MATERIALS & INTERFACES, Vol: 9, Pages: 39259-39270, ISSN: 1944-8244

JOURNAL ARTICLE

Qi J, Elson DS, 2017, Mueller polarimetric imaging for surgical and diagnostic applications: a review, JOURNAL OF BIOPHOTONICS, Vol: 10, Pages: 950-982, ISSN: 1864-063X

JOURNAL ARTICLE

Qi J, He C, Elson DS, 2017, Real time complete Stokes polarimetric imager based on a linear polarizer array camera for tissue polarimetric imaging, BIOMEDICAL OPTICS EXPRESS, Vol: 8, Pages: 4933-4946, ISSN: 2156-7085

JOURNAL ARTICLE

Qi J, He H, Lin J, Dong Y, Chen D, Ma H, Elson DSet al., 2017, Assessment of tissue polarimetric properties using Stokes polarimetric imaging with circularly polarized illumination., J Biophotonics

Tissue depolarization and linear retardance are the main polarization characteristics of interest for bulk tissue characterization, and are normally interpreted from Mueller polarimetry. Stokes polarimetry can be conducted using simpler instrumentation and in a shorter time. Here we use Stokes polarimetric imaging with circularly polarized illumination to assess the circular depolarization and linear retardance properties of tissue. Results obtained were compared with Mueller polarimetry in transmission and reflection geometry respectively. It is found that circular depolarization obtained from these two methods is very similar in both geometries, and that linear retardance is highly quantitatively similar for transmission geometry and qualitatively similar for reflection geometry. The majority of tissue circular depolarization and linear retardance image information (represented by local image contrast features) obtained from Mueller polarimetry is well preserved from Stokes polarimetry in both geometries. These findings can be referred to for further understanding tissue Stokes polarimetric data, and for further application of Stokes polarimetry under the circumstances where short acquisition time or low optical system complexity is a priority, such as polarimetric endoscopy and microscopy.

JOURNAL ARTICLE

Qi J, He H, Ma H, Elson DSet al., 2017, Extended polar decomposition method of Mueller matrices for turbid media in reflection geometry, OPTICS LETTERS, Vol: 42, Pages: 4048-4051, ISSN: 0146-9592

JOURNAL ARTICLE

Shah PL, Kemp SV, Newton RC, Elson DS, Nicholson AG, Yang G-Zet al., 2017, Clinical Correlation between Real-Time Endocytoscopy, Confocal Endomicroscopy, and Histopathology in the Central Airways, RESPIRATION, Vol: 93, Pages: 51-57, ISSN: 0025-7931

JOURNAL ARTICLE

Tonutti M, Elson DS, Yang G-Z, Darzi AW, Sodergren MHet al., 2017, The role of technology in minimally invasive surgery: state of the art, recent developments and future directions, POSTGRADUATE MEDICAL JOURNAL, Vol: 93, Pages: 159-167, ISSN: 0032-5473

JOURNAL ARTICLE

Zhang Y, Wirkert SJ, Iszatt J, Kenngott H, Wagner M, Mayer B, Stock C, Clancy NT, Elson DS, Maier-Hein Let al., 2017, Tissue classification for laparoscopic image understanding based on multispectral texture analysis, JOURNAL OF MEDICAL IMAGING, Vol: 4, ISSN: 2329-4302

JOURNAL ARTICLE

Clancy NT, Saso S, Stoyanov D, Sauvage V, Corless DJ, Boyd M, Noakes DE, Thum M-Y, Ghaem-Maghami S, Smith JR, Elson DSet al., 2016, Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep, JOURNAL OF BIOMEDICAL OPTICS, Vol: 21, ISSN: 1083-3668

JOURNAL ARTICLE

Clancy NT, Teare J, Hanna GB, Elson DSet al., 2016, Flexible multimode endoscope for tissue reflectance and autofluorescence hyperspectral imaging

© OSA 2016. A dual reflectance and autofluorescence spectral imaging probe compatible with the biopsy channels of standard flexible endoscopes is demonstrated. Spatially-resolved haemoglobin and autofluorescent signals from porcine bowel were obtained in vivo.

CONFERENCE PAPER

Elson DS, 2016, Endoscopic image-guided thermal therapy using targeted near infrared fluorescent gold nanorods, Conference on Biosensing and Nanomedicine IX, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Gallina ME, Zhou Y, Johnson CJ, Harris-Birtill D, Singh M, Zhao H, Ma D, Cass T, Elson DSet al., 2016, Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 59, Pages: 324-332, ISSN: 0928-4931

JOURNAL ARTICLE

Nabavi E, Singh M, Zhou Y, Gallina ME, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., 2016, Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods, Conference on Optical Methods for Tumor Treatment and Detection - Mechanisms and Techniques in Photodynamic Therapy XXV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Qi J, Elson DS, 2016, A high definition Mueller polarimetric endoscope for tissue characterisation, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Saso S, Jones B, Clancy N, Tziraki M, Al-MEemar M, Bracewell-Milnes T, Thum M-Y, Elson D, Smith RJet al., 2016, Imaging of organ viability during deep pelvic surgery: The use of biomedical photonics to assess uterine perfusion and vessel integrity in uterine transplantation models, Publisher: WILEY-BLACKWELL, Pages: 20-20, ISSN: 1470-0328

CONFERENCE PAPER

Singh M, Harris-Birtill DCC, Zhou Y, Gallina ME, Cass AEG, Hanna GB, Elson DSet al., 2016, Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol: 12, Pages: 481-490, ISSN: 1550-7033

JOURNAL ARTICLE

Singh M, Nabavi E, Zhou Y, Hanna G, Elson Det al., 2016, Application of Gold Nanorods in Cancer Theranostics, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 16-16, ISSN: 0007-1323

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna GB, Elson Det al., 2016, Application of Gold Nanorods in Cancer Theranostics, 57th Annual Meeting and Residents Fellow Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S1177-S1177, ISSN: 0016-5085

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass AEG, Hanna GB, Elson DSet al., 2016, Application of gold nanorods for upper gastrointestinal cancer theranostics, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS), Publisher: WILEY-BLACKWELL, Pages: 46-46, ISSN: 0007-1323

CONFERENCE PAPER

Song L, Zhou Z, Wang X, Zhao X, Elson DSet al., 2016, Simulation of speckle patterns with pre-defined correlation distributions, BIOMEDICAL OPTICS EXPRESS, Vol: 7, Pages: 798-809, ISSN: 2156-7085

JOURNAL ARTICLE

Thompson AJ, Koziej L, Williams HD, Elson DS, Yang G-Zet al., 2016, Towards optical fibre based Raman spectroscopy for the detection of surgical site infection, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Wirkert SJ, Kenngott H, Mayer B, Mietkowski P, Wagner M, Sauer P, Clancy NT, Elson DS, Maier-Hein Let al., 2016, Robust near real-time estimation of physiological parameters from megapixel multispectral images with inverse Monte Carlo and random forest regression, INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, Vol: 11, Pages: 909-917, ISSN: 1861-6410

JOURNAL ARTICLE

Zhang Y, Wirkert SJ, Iszatt J, Kenngott H, Wagner M, Mayer B, Stock C, Clancy NT, Elson DS, Maier-Hein Let al., 2016, Tissue classification for laparoscopic image understanding based on multispectral texture analysis, Conference on SPIE Image-Guided Procedures, Robotic Interventions, and Modeling, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Arya S, Chalau V, Singh M, Clancy NT, Kudo H, Goldin RD, Elson DS, Hanna GBet al., 2015, Bipolar radiofrequency energy as a novel method of bowel anastomosis: results of a comparative animal study, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, Publisher: WILEY-BLACKWELL, Pages: 38-38, ISSN: 0007-1323

CONFERENCE PAPER

Avila Rencoret FB, Elson DS, Mylonas G, 2015, Probe Deployment Device

PATENT

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