Imperial College London
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DR. DANIEL MUNBLIT

Faculty of Medicine, Department of Infectious Disease

Visiting Reader
 
 
 
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Contact

 

daniel.munblit08 Website CV

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{ISARIC:2021:10.1007/s15010-021-01599-5,
author = {ISARIC, Clinical Characterisation Group},
doi = {10.1007/s15010-021-01599-5},
journal = {Infection: journal of infectious disease},
pages = {899--905},
title = {COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study},
url = {http://dx.doi.org/10.1007/s15010-021-01599-5},
volume = {49},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. METHODS: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. RESULTS: 'Typical' symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. INTERPRETATION: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
AU  - ISARIC,Clinical Characterisation Group
DO  - 10.1007/s15010-021-01599-5
EP  - 905
PY  - 2021///
SN  - 0300-8126
SP  - 899
TI  - COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
T2  - Infection: journal of infectious disease
UR  - http://dx.doi.org/10.1007/s15010-021-01599-5
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34170486
UR  - https://link.springer.com/article/10.1007%2Fs15010-021-01599-5
UR  - http://hdl.handle.net/10044/1/90440
VL  - 49
ER  -
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