Imperial College London
Portrait Picture

DR. DANIEL MUNBLIT

Faculty of Medicine, Department of Infectious Disease

Visiting Reader
 
 
 
//

Contact

 

daniel.munblit08 Website CV

 
 
//

Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Sigfrid:2021:10.1016/j.lanepe.2021.100186,
author = {Sigfrid, L and Drake, TM and Pauley, E and Jesudason, EC and Olliaro, P and Lim, WS and Gillesen, A and Berry, C and Lowe, DJ and McPeake, J and Lone, N and Munblit, D and Cevik, M and Casey, A and Bannister, P and Russell, CD and Goodwin, L and Ho, A and Turtle, L and O'Hara, ME and Hastie, C and Donohue, C and Spencer, RG and Donegan, C and Gummery, A and Harrison, J and Hardwick, HE and Hastie, CE and Carson, G and Merson, L and Baillie, JK and Openshaw, P and Harrison, EM and Docherty, AB and Semple, MG and Scott, JT and ISARIC4C, investigators},
doi = {10.1016/j.lanepe.2021.100186},
journal = {The Lancet Regional Health - Europe},
pages = {1--13},
title = {Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.},
url = {http://dx.doi.org/10.1016/j.lanepe.2021.100186},
volume = {8},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: This study sought to establish the long-term effects of Covid-19 following hospitalisation. Methods: 327 hospitalised participants, with SARS-CoV-2 infection were recruited into a prospective multicentre cohort study at least 3 months post-discharge. The primary outcome was self-reported recovery at least ninety days after initial Covid-19 symptom onset. Secondary outcomes included new symptoms, disability (Washington group short scale), breathlessness (MRC Dyspnoea scale) and quality of life (EQ5D-5L). Findings: 55% of participants reported not feeling fully recovered. 93% reported persistent symptoms, with fatigue the most common (83%), followed by breathlessness (54%). 47% reported an increase in MRC dyspnoea scale of at least one grade. New or worse disability was reported by 24% of participants. The EQ5D-5L summary index was significantly worse following acute illness (median difference 0.1 points on a scale of 0 to 1, IQR: -0.2 to 0.0). Females under the age of 50 years were five times less likely to report feeling recovered (adjusted OR 5.09, 95% CI 1.64 to 15.74), were more likely to have greater disability (adjusted OR 4.22, 95% CI 1.12 to 15.94), twice as likely to report worse fatigue (adjusted OR 2.06, 95% CI 0.81 to 3.31) and seven times more likely to become more breathless (adjusted OR 7.15, 95% CI 2.24 to 22.83) than men of the same age. Interpretation: Survivors of Covid-19 experienced long-term symptoms, new disability, increased breathlessness, and reduced quality of life. These findings were present in young, previously healthy working age adults, and were most common in younger females. Funding: National Institute for Health Research, UK Medical Research Council, Wellcome Trust, Department for International Development and the Bill and Melinda Gates Foundation.
AU  - Sigfrid,L
AU  - Drake,TM
AU  - Pauley,E
AU  - Jesudason,EC
AU  - Olliaro,P
AU  - Lim,WS
AU  - Gillesen,A
AU  - Berry,C
AU  - Lowe,DJ
AU  - McPeake,J
AU  - Lone,N
AU  - Munblit,D
AU  - Cevik,M
AU  - Casey,A
AU  - Bannister,P
AU  - Russell,CD
AU  - Goodwin,L
AU  - Ho,A
AU  - Turtle,L
AU  - O'Hara,ME
AU  - Hastie,C
AU  - Donohue,C
AU  - Spencer,RG
AU  - Donegan,C
AU  - Gummery,A
AU  - Harrison,J
AU  - Hardwick,HE
AU  - Hastie,CE
AU  - Carson,G
AU  - Merson,L
AU  - Baillie,JK
AU  - Openshaw,P
AU  - Harrison,EM
AU  - Docherty,AB
AU  - Semple,MG
AU  - Scott,JT
AU  - ISARIC4C,investigators
DO  - 10.1016/j.lanepe.2021.100186
EP  - 13
PY  - 2021///
SN  - 2666-7762
SP  - 1
TI  - Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.
T2  - The Lancet Regional Health - Europe
UR  - http://dx.doi.org/10.1016/j.lanepe.2021.100186
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34386785
UR  - https://www.sciencedirect.com/science/article/pii/S2666776221001630?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91332
VL  - 8
ER  -
Download