Imperial College London

ProfessorDavidBrooks

Faculty of MedicineDepartment of Medicine

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

821 results found

Brooks D, Widespread microglial activation in multiple system atrophy, Movement Disorders, ISSN: 0885-3185

JOURNAL ARTICLE

McGinnity CJ, Arstad E, Beck K, Brooks DJ, Coles JP, Duncan JS, Galovic M, Hinz R, Hirani E, Howes OD, Jones PA, Koepp MJ, Luo F, Barros DAR, Singh N, Trigg W, Hammers Aet al., 2019, Comment on "In Vivo [F-18]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates", ACS CHEMICAL NEUROSCIENCE, Vol: 10, Pages: 768-772, ISSN: 1948-7193

JOURNAL ARTICLE

Lillethorup TP, Glud AN, Landeck N, Alstrup AKO, Jakobsen S, Vang K, Doudet DJ, Brooks DJ, Kirik D, Hinz R, Sorensen JC, Landau AMet al., 2018, In vivo quantification of glial activation in minipigs overexpressing human alpha-synuclein, SYNAPSE, Vol: 72, ISSN: 0887-4476

JOURNAL ARTICLE

Femminella G, Dani M, Wood M, Fan Z, Calsolaro V, Atkinson R, Edginton T, Hinz R, Brooks D, Edison Pet al., Microglial activation in early Alzheimer trajectory is associated with higher grey matter volume, Neurology, ISSN: 1526-632X

Objective: To investigate the influence of microglial activation in the early stages of Alzheimer’s disease trajectory, we assessed the relationship between microglial activation and grey matter volume and hippocampal volume in MCI patients.Methods: In this study, fifty-five participants (37 early stages MCI and 18 controls) underwent [11C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate grey matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [11C]PBR28 VT(volume of distribution) was calculated using arterial input function and Logan Graphical analysis. Grey matter volume and hippocampal volumes were calculated from MRI for each subject. Statistical parametric mapping software was used to perform voxel-wise correlations and biological parametric mapping analysis. Amyloid status was assessed using [18F]Flutemetamol PET.Results: Higher [11C]PBR28 VT in different cortical areas correlated with higher grey matter volume in both amyloid positive and negative MCI. Additionally, higher hippocampal volume correlated with higher cortical [11C]PBR28 Logan VT.Conclusions: In this in vivo study, we have demonstrated that microglial activation quantified using [11C]PBR28 PET was associated with higher grey matter volume and higher hippocampal volume in MCI patients. This may suggest that microglial activation may not always be associatedwith neuronal damage, and indeed it may have beneficial effect in early stages of Alzheimer’s trajectory. While further longitudinal studies are necessary, these findings have significant implications on therapeutic strategies targeting microglial activation.

JOURNAL ARTICLE

Sridharan S, Raffel J, Nandoskar A, Record C, Brooks D, Owen D, Sharp D, Muraro P, Gunn R, Nicholas Ret al., 2018, Confirmation of specific binding of the 18 kDa translocator protein (TSPO) radioligand [F-18]GE-180: a blocking study using XDB173 in multiple sclerosis, 34th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 421-422, ISSN: 1352-4585

CONFERENCE PAPER

Dani M, Wood M, Mizoguchi R, Fan Z, Walker Z, Morgan R, Hinz R, Biju M, Kuruvilla T, Brooks DJ, Edison Pet al., 2018, Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease, BRAIN, Vol: 141, Pages: 2740-2754, ISSN: 0006-8950

JOURNAL ARTICLE

Parbo P, Ismail R, Sommerauer M, Stokholm MG, Hansen AK, Hansen KV, Amidi A, Schaldemose JL, Gottrup H, Braendgaard H, Eskildsen SF, Borghammer P, Hinz R, Aanerud J, Brooks DJet al., 2018, Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study, NEUROBIOLOGY OF DISEASE, Vol: 117, Pages: 211-216, ISSN: 0969-9961

JOURNAL ARTICLE

Calsolaro V, Fan Z, Veronese M, Femminella G, Pasqualetti G, Trigg W, Buckley C, Turkheimer F, Gentleman S, Hinz R, Brooks D, Edison Pet al., 2018, Novel third generation microglial marker flutriciclamide ([18F]GE180) in Alzheimer’s disease and mild cognitive impairment, Alzheimer's and Dementia, Vol: 14, Pages: P506-P506, ISSN: 1552-5260

JOURNAL ARTICLE

Femminella G, Fan Z, Frangou E, Love S, Calsolaro V, Holmes C, Ritchie C, Lawrence R, McFarlane B, Tadros G, Ridha B, Bannister C, Walker Z, Archer H, Coulthard E, Underwood B, Prasanna A, Korentang P, Karim S, Junaid K, McGuinness B, Passmore P, Nilforooshan R, Macharouthu A, Donaldson A, Thacker S, Russell G, Malik N, Mate V, Knight L, Kshemendran S, Harrison J, Ballard C, Brooks D, Edison Pet al., 2018, Peripheral insulin resistance does not correlate with cerebral glucose metabolic rate in non-diabetic Alzheimer’s patients, Alzheimer's and Dementia, Vol: 14, Pages: P1157-P1158, ISSN: 1552-5260

JOURNAL ARTICLE

Minett T, Su L, Mak E, Williams G, Firbank M, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn D, O'Brien JTet al., 2018, Longitudinal diffusion tensor imaging changes in early Parkinson's disease: ICICLE-PD study, JOURNAL OF NEUROLOGY, Vol: 265, Pages: 1528-1539, ISSN: 0340-5354

JOURNAL ARTICLE

Knudsen K, Fedorova TD, Hansen AK, Sommerauer M, Otto M, Svendsen KB, Nahimi A, Stokholm MG, Pavese N, Beier CP, Brooks DJ, Borghammer Pet al., 2018, In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study, LANCET NEUROLOGY, Vol: 17, Pages: 618-628, ISSN: 1474-4422

JOURNAL ARTICLE

Fan Z, Dani M, Femminella GD, Wood M, Calsolaro V, Veronese M, Turkheimer F, Gentleman S, Brooks DJ, Hinz R, Edison Pet al., 2018, Parametric mapping using spectral analysis for C-11-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 45, Pages: 1432-1441, ISSN: 1619-7070

JOURNAL ARTICLE

Stokholm MG, Iranzo A, Ostergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Parbo P, Borghammer P, Santamaria J, Moller A, Gaig C, Brooks DJ, Tolosa E, Pavese Net al., 2018, Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder, NEUROBIOLOGY OF DISEASE, Vol: 115, Pages: 9-16, ISSN: 0969-9961

JOURNAL ARTICLE

Mattsson N, Groot C, Jansen WJ, Landau SM, Villemagne VL, Engelborghs S, Mintun MM, Lleo A, Molinuevo JL, Jagust WJ, Frisoni GB, Ivanoiu A, Chetelat G, de Oliveira CR, Rodrigue KM, Kornhuber J, Wallin A, Klimkowicz-Mrowiec A, Kandimalla R, Popp J, Aalten PP, Aarsland D, Alcolea D, Almdahl IS, Baldeiras I, van Buchem MA, Cavedo E, Chen K, Cohen AD, Foerster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gill KD, Gkatzima O, Grimmer T, Hampel H, Herukka S-K, Johannsen P, van Laere K, de Leon MJ, Maier W, Marcusson J, Meulenbroek O, Mollergard HM, Morris JC, Mroczko B, Nordlund A, Prabhakar S, Peters O, Rami L, Rodriguez-Rodriguez E, Roe CM, Ruther E, Santana I, Schroder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Verhey FRJ, Vos SJB, van Doorn LJCVW, Waldemar G, Wallin AK, Wiltfang J, Vandenberghe R, Brooks DJ, Fladby T, Rowe CC, Drzezga A, Verbeek MM, Sarazin M, Wolk DA, Fleisher AS, Klunk WE, Na DL, Sanchez-Juan P, Lee DY, Nordberg A, Tsolaki M, Camus V, Rinne JO, Fagan AM, Zetterberg H, Blennow K, Rabinovici GD, Hansson O, van Berckel BNM, van der Flier WM, Scheltens P, Visser PJ, Ossenkoppele Ret al., 2018, Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimer's disease, ALZHEIMERS & DEMENTIA, Vol: 14, Pages: 913-924, ISSN: 1552-5260

JOURNAL ARTICLE

McGinnity CJ, Barros DAR, Trigg W, Brooks DJ, Hinz R, Duncan JS, Koepp MJ, Hammers Aet al., 2018, Simplifying [F-18]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?, EJNMMI RESEARCH, Vol: 8, ISSN: 2191-219X

JOURNAL ARTICLE

Sommerauer M, Hansen AK, Parbo P, Fedorova TD, Knudsen K, Frederiksen Y, Nahimi A, Barbe MT, Brooks DJ, Borghammer Pet al., 2018, Decreased Noradrenaline Transporter Density in the Motor Cortex of Parkinson's Disease Patients, MOVEMENT DISORDERS, Vol: 33, Pages: 1006-1009, ISSN: 0885-3185

JOURNAL ARTICLE

Hansen AK, Brooks DJ, Borghammer P, 2018, MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([F-18]-AV-1451) Binding, MOLECULAR IMAGING AND BIOLOGY, Vol: 20, Pages: 356-360, ISSN: 1536-1632

JOURNAL ARTICLE

Lillethorup TP, Glud AN, Alstrup AKO, Mikkelsen TW, Nielsen EH, Zaer H, Doudet DJ, Brooks DJ, Sorensen JCH, Orlowski D, Landau AMet al., 2018, Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs, EXPERIMENTAL NEUROLOGY, Vol: 303, Pages: 142-152, ISSN: 0014-4886

JOURNAL ARTICLE

Jeppesen J, Otto M, Frederiksen Y, Hansen AK, Fedorova TD, Knudsen K, Nahimi A, Brooks DJ, Borghammer P, Sommerauer Met al., 2018, Observations on muscle activity in REM sleep behavior disorder assessed with a semi-automated scoring algorithm, CLINICAL NEUROPHYSIOLOGY, Vol: 129, Pages: 541-547, ISSN: 1388-2457

JOURNAL ARTICLE

Pasquini J, Ceravolo R, Qamhawi Z, Lee J-Y, Deuschl G, Brooks DJ, Bonuccelli U, Pavese Net al., 2018, Progression of tremor in early stages of Parkinson's disease: a clinical and neuroimaging study, BRAIN, Vol: 141, Pages: 811-821, ISSN: 0006-8950

JOURNAL ARTICLE

Sommerauer M, Fedorova TD, Hansen AK, Knudsen K, Otto M, Jeppesen J, Frederiksen Y, Blicher JU, Geday J, Nahimi A, Damholdt MF, Brooks DJ, Borghammer Pet al., 2018, Evaluation of the noradrenergic system in Parkinson's disease: an C-11-MeNER PET and neuromelanin MRI study, BRAIN, Vol: 141, Pages: 496-504, ISSN: 0006-8950

JOURNAL ARTICLE

Edison P, Brooks DJ, 2018, Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET, JOURNAL OF ALZHEIMERS DISEASE, Vol: 64, Pages: S339-S351, ISSN: 1387-2877

JOURNAL ARTICLE

Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleo A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chetelat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, de Oliveira CR, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonca A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJet al., 2018, Association of Cerebral Amyloid-beta Aggregation With Cognitive Functioning in Persons Without Dementia, JAMA PSYCHIATRY, Vol: 75, Pages: 84-95, ISSN: 2168-622X

JOURNAL ARTICLE

Ismail R, Hansen AK, Parbo P, Brændgaard H, Gottrup H, Brooks DJ, Borghammer Pet al., 2018, The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease., Int J Alzheimers Dis, Vol: 2018, ISSN: 2090-8024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid-β (Aβ) and hyperphosphorylated tau. No effective disease modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Aβ load in transgenic mice. We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients. We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker. Six Aβ positive patients received 10 days of light therapy, had 2 hours of daily exposure, and underwent a postintervention PiB PET on day 11. After 10 days of light therapy, no significant decrease of PiB SUVR values was detected in any volumes of interest tested (primary visual cortex, visual association cortex, lateral parietal cortex, precuneus, and posterior cingulate) or in the total motor cortex, and longer treatments may be necessary to induce amyloid removal in humans.

JOURNAL ARTICLE

Stokholm MG, Iranzo A, Ostergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Moller A, Gaig C, Brooks DJ, Tolosa E, Pavese Net al., 2017, Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study, LANCET NEUROLOGY, Vol: 16, Pages: 789-796, ISSN: 1474-4422

JOURNAL ARTICLE

Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, Marras C, Tanner CM, Ross GW, Langston JW, Klein C, Bonifati V, Jankovic J, Lozano AM, Deuschl G, Bergman H, Tolosa E, Rodriguez-Violante M, Fahn S, Postuma RB, Berg D, Marek K, Standaert DG, Surmeier DJ, Olanow CW, Kordower JH, Calabresi P, Schapira AHV, Stoessl AJet al., 2017, Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy., Mov Disord, Vol: 32, Pages: 1264-1310

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.

JOURNAL ARTICLE

Lawson RA, Yarnall AJ, Duncan GW, Breen DP, Khoo TK, Williams-Gray CH, Barker RA, Burn DJ, ICICLE-PD study groupet al., 2017, Stability of mild cognitive impairment in newly diagnosed Parkinson's disease., J Neurol Neurosurg Psychiatry, Vol: 88, Pages: 648-652

BACKGROUND: Mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). We evaluated the stability of PD-MCI over time to determine its clinical utility as a marker of disease. METHODS: 212 newly diagnosed participants with PD were recruited into a longitudinal study and reassessed after 18 and 36 months. Participants completed a range of clinical and neuropsychological assessments. PD-MCI was classified using Movement Disorders Society Task Force level I (Montreal Cognitive Assessment <26) and level II (using cut-offs of 1, 1.5 and 2SD) criteria. RESULTS: After 36 months, 75% of participants returned; 8% of patients had developed a dementia all of which were previously PD-MCI. Applying level I criteria, 70% were cognitively stable, 19% cognitively declined and 11% improved over 36 months. Applying level II criteria (1, 1.5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improved and 19% fluctuated over 36 months. 18% of participants reverted to normal cognition from PD-MCI. DISCUSSION: Cognitive impairment in PD is complex, with some individuals' function fluctuating over time and some reverting to normal cognition. PD-MCI level I criteria may have greater clinical convenience, but more comprehensive level II criteria with 2SD cut-offs may offer greater diagnostic certainty.

JOURNAL ARTICLE

Dani M, Wood M, Mizoguchi R, Fan Z, Brooks D, Edison Pet al., 2017, Different modelling approaches for tau tracer 18F-AV1451 in mild cognitive impairment and Alzheimer's disease, Alzheimer's and Dementia, Vol: 13, Pages: P291-P292, ISSN: 1552-5260

JOURNAL ARTICLE

Femminella G, Dani M, Wood M, Fan Z, Calsolaro V, Mitzoguchi R, Atkinson RA, Edgington T, Waldman A, Hinz R, Brooks D, Edison Pet al., 2017, Microglial activation is associated with higher grey matter density and hippocampal volume in MCi subjects, Alzheimer's and Dementia, Vol: 13, Pages: P921-P921, ISSN: 1552-5260

JOURNAL ARTICLE

Fan Z, Femminella GD, Calsolaro V, Veronese M, Turkheimer F, Brooks DJ, Hinz R, Edison Pet al., 2017, Strategies to develop parametric maps for TSPO PET tracer [11C]-PBR28 in patients with mild cognitive impairment, Alzheimer's and Dementia, Vol: 13, Pages: P288-P289, ISSN: 1552-5260

JOURNAL ARTICLE

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