Publications
1042 results found
Brooks DJ, 1997, Advances in imaging Parkinson's disease: Editorial review, CURRENT OPINION IN NEUROLOGY, Vol: 10, Pages: 327-331, ISSN: 1350-7540
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- Citations: 24
Rabey JM, Bass H, Bonuccelli U, et al., 1997, Evaluation of the Short Parkinson's Evaluation Scale: A new friendly scale for the evaluation of Parkinson's disease in clinical drug trials, CLINICAL NEUROPHARMACOLOGY, Vol: 20, Pages: 322-337, ISSN: 0362-5664
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- Citations: 56
Samuel M, CeballosBaumann AO, Turjanski N, et al., 1997, Pallidotomy in Parkinson's disease increases supplementary motor area and prefrontal activation during performance of volitional movements - An (H2O)-O-15 PET study, BRAIN, Vol: 120, Pages: 1301-1313, ISSN: 0006-8950
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- Citations: 150
Turjanski N, Lees AJ, Brooks DJ, 1997, Dopaminergic function in patients with posttraumatic Parkinsonism: An F-18-dopa PET study, NEUROLOGY, Vol: 49, Pages: 183-189, ISSN: 0028-3878
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- Citations: 21
Wenning GK, Odin P, Morrish P, et al., 1997, Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease, ANNALS OF NEUROLOGY, Vol: 42, Pages: 95-107, ISSN: 0364-5134
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- Citations: 293
Samuel M, CeballosBaumann AO, Blin J, et al., 1997, Evidence for lateral premotor and parietal overactivity in Parkinson's disease during sequential and bimanual movements - A PET study, BRAIN, Vol: 120, Pages: 963-976, ISSN: 0006-8950
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- Citations: 331
Kew JJM, Halligan PW, Marshall JC, et al., 1997, Abnormal access of axial vibrotactile input to deafferented somatosensory cortex in human upper limb amputees, JOURNAL OF NEUROPHYSIOLOGY, Vol: 77, Pages: 2753-2764, ISSN: 0022-3077
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- Citations: 62
Abrahams S, Goldstein LH, AlChalabi A, et al., 1997, Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 62, Pages: 464-472, ISSN: 0022-3050
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- Citations: 200
Brooks DJ, 1997, PET and SPECT studies in Parkinson's disease, BAILLIERES CLINICAL NEUROLOGY, Vol: 6, Pages: 69-87, ISSN: 0961-0421
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- Citations: 41
CeballosBaumann AO, Sheean G, Passingham RE, et al., 1997, Botulinum toxin does not reverse the cortical dysfunction associated with writer's cramp - A PET study, BRAIN, Vol: 120, Pages: 571-582, ISSN: 0006-8950
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- Citations: 183
Jueptner M, Frith CD, Brooks DJ, et al., 1997, Anatomy of motor learning .2. Subcortical structures and learning by trial and error, JOURNAL OF NEUROPHYSIOLOGY, Vol: 77, Pages: 1325-1337, ISSN: 0022-3077
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- Citations: 384
Jueptner M, Stephan KM, Frith CD, et al., 1997, Anatomy of motor learning .1. Frontal cortex and attention to action, JOURNAL OF NEUROPHYSIOLOGY, Vol: 77, Pages: 1313-1324, ISSN: 0022-3077
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- Citations: 524
Piccini P, Morrish PK, Turjanski N, et al., 1997, Dopaminergic function in familial Parkinson's disease: A clinical and F-18-dopa positron emission tomography study, ANNALS OF NEUROLOGY, Vol: 41, Pages: 222-229, ISSN: 0364-5134
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- Citations: 117
Weeks RA, Cunningham VJ, Piccini P, et al., 1997, <sup>11</sup>C-diprenorphine binding in Huntington's disease: A comparison of region of interest analysis with statistical parametric mapping, Journal of Cerebral Blood Flow and Metabolism, Vol: 17, Pages: 943-949, ISSN: 0271-678X
We compare region of interest (ROI) analytical approaches with statistical parametric mapping (SPM) of 11C-diprenorphine positron emission tomography findings in five patients with Huntington's disease (HD) and nine age-matched controls. The ROI were placed on caudate, putamen, and an occipital reference area. Ratios of striatal-occipital uptake from averaged static images centered at 60 minutes showed a mean 20% reduction in caudate (P = 0.034) and 15% reduction in putamen (P = 0.095) receptor binding in the HD patients. Dynamic data from caudate and putamen ROI, together with a plasma tracer input function, were analyzed using spectral analysis to give regional impulse response functions. Regional data at 60 minutes after impulse showed a mean 29% decrease in caudate (P = 0.006) and 23% decrease in putamen (P = 0.029) opioid binding in the HD cohort. Parametric images of tracer binding also were produced with spectral analysis on a voxel basis. The images of the unit impulse response function at 60 minutes showed a mean 31% decrease in caudate (P = 0.005) and a 26% decrease in putamen binding (P = 0.011) in HD. The voxel-based parametric images were transformed into standard stereotactic space, and a between-group comparison (patient versus controls) was performed with SPM. This approach revealed symmetrical decreases in caudate (peak 40% decrease, z score = 4.38) and putamen opioid binding (peak 24% decrease, z score = 4.686) with additional nonhypothesized changes in cingulate, prefrontal, and thalamic areas. The significance and precision of changes measured with spectral analysis applied to dynamic data sets were superior to ROI-based ratio analysis on static images. The SPM replicated the striatal reductions in opioid binding in HD and detected additional nonpredicted changes. This study suggests that SPM is a valid alternative to conventional ROI analytical approaches for determining binding changes with positron emission tomography and may have advantages o
Koepp MJ, Richardson MP, Labbé C, et al., 1997, <sup>11</sup>C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy, Neurology, Vol: 49, Pages: 764-773, ISSN: 0028-3878
Background: Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS). The limited spatial resolution of PET, however, results in partial-volume averaging that affects quantitative analysis of cBZR density. Method: We determined hippocampal volume loss and reduction in cBZR binding using an MRI-based method for partial-volume effect correction of 11C-FMZ volume of distribution (FMZ- Vd) in 17 patients with refractory mTLE and an MRI diagnosis of HS that was subsequently histologically verified in all cases. Quantitative neuropathology was performed with assessment of neuron density in 14 of the 17 patients. Absolute FMZ-Vd and asymmetry indices (FMZ-AI) were compared before and after partial-volume effect correction with MRI-determined hippocampal volumes (HCV), hippocampal T2 measurements, and, if available, neuronal cell densities. Results: Compared with 15 age-matched healthy volunteers, significant reductions of absolute hippocampal FMZ-Vd were found before correction for partial-volume effects in 11 of 17 patients (65%) and only abnormal FMZ-AI in the other six patients. After partial-volume effect correction all 17 patients (100%) showed both significant unilateral reduction of absolute FMZ-Vd and abnormal FMZ-AI. There was no correlation between corrected absolute FMZ-Vd and HCV or neuronal cell density. After correction for partial-volume effect we found a mean 38% reduction of FMZ-Vd in the sclerosed hippocampus, over and above the reduction of HCV. Conclusion: Correction for partial-volume effect allows absolute quantitation of FMZ-PET and increases its sensitivity for detecting abnormalities in TLE due to HS. The lack of correlation between cBZR binding and neuronal density implies that atrophy with neuron loss is not the sole determinant of reduced cBZR binding
Brooks DJ, 1997, Advances in imaging Parkinson's disease, Current Opinion in Neurology, Vol: 10, Pages: 327-331, ISSN: 1350-7540
Positron emission tomography and single photon emission computed tomography both now provide an objective means of quantitating loss of striatal dopaminergic terminal function in Parkinson's disease and of following disease progression. 18F-dopa positron emission tomography can also detect frontal changes in Parkinson's disease and preclinical disease in 30% of asymptomatic adult relatives of familial cases. Positron emission tomography, single photon emission computed tomography and proton magnetic resonance spectroscopy are all useful for distinguishing Parkinson's disease from atypical syndromes where diagnostic doubt exists.
Chaudhuri KR, Richards M, Brooks DJ, 1997, How far are we in understanding the cause of Parkinson's disease?, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 62, Pages: 104-104, ISSN: 0022-3050
Boecker H, Wills AJ, CeballosBaumann A, et al., 1997, Stereotactic thalamotomy in tremor-dominant Parkinson's disease: An (H2O)-O-15 PET motor activation study, ANNALS OF NEUROLOGY, Vol: 41, Pages: 108-111, ISSN: 0364-5134
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- Citations: 38
Brooks DJ, 1997, Motor disturbance and brain functional imaging in Parkinson's disease, EUROPEAN NEUROLOGY, Vol: 38, Pages: 26-32, ISSN: 0014-3022
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- Citations: 15
Turjanski N, Brooks DJ, 1997, PET and the investigation of dementia in the parkinsonian patient, JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, Pages: 37-48, ISSN: 0303-6995
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- Citations: 20
Ceballos-Baumann AO, Brooks DJ, 1997, Basal ganglia function and dysfunction revealed by PET activation studies, ADVANCES IN NEUROLOGY, VOLUME 74, Vol: 74, Pages: 127-139, ISSN: 0091-3952
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- Citations: 29
Morrish PK, Sawle GV, Brooks DJ, 1996, Regional changes in [F-18]dopa metabolism in the striatum in Parkinson's disease, BRAIN, Vol: 119, Pages: 2097-2103, ISSN: 0006-8950
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- Citations: 112
Abrahams S, Goldstein LH, Kew JJM, et al., 1996, Frontal lobe dysfunction in amyotrophic lateral sclerosis - A PET study, BRAIN, Vol: 119, Pages: 2105-2120, ISSN: 0006-8950
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- Citations: 230
Jueptner M, Jenkins IH, Brooks DJ, et al., 1996, The sensory guidance of movement: A comparison of the cerebellum and basal ganglia, EXPERIMENTAL BRAIN RESEARCH, Vol: 112, Pages: 462-474, ISSN: 0014-4819
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- Citations: 60
Rajput AH, 1996, Specificity of ethanol in essential tremor, ANNALS OF NEUROLOGY, Vol: 40, Pages: 950-950, ISSN: 0364-5134
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- Citations: 1
Koepp MJ, Richardson MP, Brooks DJ, et al., 1996, Cerebral benzodiazepine receptors in hippocampal sclerosis - An objective in vivo analysis, BRAIN, Vol: 119, Pages: 1677-1687, ISSN: 0006-8950
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- Citations: 96
Richardson MP, Koepp MJ, Brooks DJ, et al., 1996, Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: An C-11-flumazenil PET study, ANNALS OF NEUROLOGY, Vol: 40, Pages: 188-198, ISSN: 0364-5134
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- Citations: 120
Gjedde A, 1996, DOPA decarboxylase, MOVEMENT DISORDERS, Vol: 11, Pages: 462-463, ISSN: 0885-3185
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- Citations: 2
Weeks RA, Piccini P, Harding AE, et al., 1996, Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease, ANNALS OF NEUROLOGY, Vol: 40, Pages: 49-54, ISSN: 0364-5134
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- Citations: 162
OpackaJuffry J, Brooks DJ, 1996, DOPA decarboxylase - Reply, MOVEMENT DISORDERS, Vol: 11, Pages: 463-463, ISSN: 0885-3185
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