ProfessorDavidBrooks

Sommerauer M, Hansen AK, Parbo P, Fedorova TD, Knudsen K, Frederiksen Y, Nahimi A, Barbe MT, Brooks DJ, Borghammer Pet al., 2018, Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients, Movement Disorders, Vol: 33, Pages: 1006-1010, ISSN: 0885-3185

Reduced noradrenaline levels have been reported to occur in the motor cortices of PD patients postmortem. Imaging techniques have recently become available to specifically study noradrenergic terminal function in vivo using PET. The objective of this study was to evaluate cortical 11 C-MeNER binding in PD patients. Thirty PD patients and 12 healthy control subjects comparable in age, sex, and cognitive performance underwent PET imaging with 11 C-MeNER, a specific ligand of the noradrenaline transporter. Cortical noradrenaline transporter binding was compared at a voxel level using Statistical Parametric Mapping, whereas cortical thickness was assessed using FreeSurfer software with MRI. PD patients showed reduced 11 C-MeNER binding in the primary motor cortex unrelated to cortical thickness; other cortical regions did not differ between groups. In a subgroup analysis, patients with higher Hoehn & Yahr stage exhibited more pronounced 11 C-MeNER binding reductions. Loss of cortical noradrenergic projections to the primary motor cortex occurs in PD associated with disease stage. © 2018 International Parkinson and Movement Disorder Society.

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Chaudhuri KR, Poewe W, Brooks D, 2018, Motor and Nonmotor Complications of Levodopa: Phenomenology, Risk Factors, and Imaging Features, MOVEMENT DISORDERS, Vol: 33, Pages: 909-919, ISSN: 0885-3185

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• Citations: 71

Hansen AK, Brooks DJ, Borghammer P, 2018, MAO-B Inhibitors Do Not Block <i>In Vivo</i> Flortaucipir([<SUP>18</SUP>F]-AV-1451) Binding, MOLECULAR IMAGING AND BIOLOGY, Vol: 20, Pages: 356-360, ISSN: 1536-1632

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• Citations: 38

Prasad S, Pal PK, 2018, Levodopa-Induced Dyskinesia: "TRAP"ping the Culprit., Mov Disord, Vol: 33

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Jeppesen J, Otto M, Frederiksen Y, Hansen A, Fedorova T, Knudsen K, Nahimi A, Brooks D, Borghammer P, Sommerauer Met al., 2018, F26. Automated chin EMG analysis for quantification of REM sleep without atonia, Clinical Neurophysiology, Vol: 129, Pages: e76-e76, ISSN: 1388-2457

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Lillethorup TP, Glud AN, Alstrup AKO, Mikkelsen TW, Nielsen EH, Zaer H, Doudet DJ, Brooks DJ, Sorensen JCH, Orlowski D, Landau AMet al., 2018, Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs, EXPERIMENTAL NEUROLOGY, Vol: 303, Pages: 142-152, ISSN: 0014-4886

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• Citations: 22

Pasquini J, Ceravolo R, Qamhawi Z, Lee J-Y, Deuschl G, Brooks DJ, Bonuccelli U, Pavese Net al., 2018, Progression of tremor in early stages of Parkinson's disease: a clinical and neuroimaging study, BRAIN, Vol: 141, Pages: 811-821, ISSN: 0006-8950

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• Citations: 72

Jeppesen J, Otto M, Frederiksen Y, Hansen AK, Fedorova TD, Knudsen K, Nahimi A, Brooks DJ, Borghammer P, Sommerauer Met al., 2018, Observations on muscle activity in REM sleep behavior disorder assessed with a semi-automated scoring algorithm, CLINICAL NEUROPHYSIOLOGY, Vol: 129, Pages: 541-547, ISSN: 1388-2457

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• Citations: 7

Rumbaugh N, Shen Y, Morganson E, Liu X, Banerji M, McMahon RG, Abdalla FB, Benoit-Lévy A, Bertin E, Brooks D, Buckley-Geer E, Capozzi D, Carnero Rosell A, Carrasco Kind M, Carretero J, Cunha CE, D'Andrea CB, Da Costa LN, Depoy DL, Desai S, Doel P, Frieman J, García-Bellido J, Gruen D, Gruendl RA, Gschwend J, Gutierrez G, Honscheid K, James DJ, Kuehn K, Kuhlmann S, Kuropatkin N, Lima M, Maia MAG, Marshall JL, Martini P, Menanteau F, Plazas AA, Reil K, Roodman A, Sanchez E, Scarpine V, Schindler R, Schubnell M, Sheldon E, Smith M, Soares-Santos M, Sobreira F, Suchyta E, Swanson MEC, Walker AR, Wester Wet al., 2018, Extreme Variability Quasars from the Sloan Digital Sky Survey and the Dark Energy Survey, Astrophysical Journal, Vol: 854, ISSN: 0004-637X

We perform a systematic search for long-term extreme variability quasars (EVQs) in the overlapping Sloan Digital Sky Survey and 3 Year Dark Energy Survey imaging, which provide light curves spanning more than 15 years. We identified ∼1000 EVQs with a maximum change in g-band magnitude of more than 1 mag over this period, about 10% of all quasars searched. The EVQs have L bol ∼ 1045-1047 erg s-1 and L/L Edd ∼ 0.01-1. Accounting for selection effects, we estimate an intrinsic EVQ fraction of ∼30%-50% among all quasars over a baseline of ∼15 yr. We performed detailed multi-wavelength, spectral, and variability analyses for the EVQs and compared them to their parent quasar sample. We found that EVQs are distinct from a control sample of quasars matched in redshift and optical luminosity: (1) their UV broad emission lines have larger equivalent widths; (2) their Eddington ratios are systematically lower; and (3) they are more variable on all timescales. The intrinsic difference in quasar properties for EVQs suggests that internal processes associated with accretion are the main driver for the observed extreme long-term variability. However, despite their different properties, EVQs seem to be in the tail of a continuous distribution of quasar properties, rather than standing out as a distinct population. We speculate that EVQs are normal quasars accreting at relatively low rates, where the accretion flow is more likely to experience instabilities that drive the changes in flux by a factor of a few on multi-year timescales.

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• Citations: 85

Smith M, Sullivan M, Nichol RC, Galbany L, D'Andrea CB, Inserra C, Lidman C, Rest A, Schirmer M, Filippenko AV, Zheng W, Bradley Cenko S, Angus CR, Brown PJ, Davis TM, Finley DA, Foley RJ, González-Gaitán S, Gutiérrez CP, Kessler R, Kuhlmann S, Marriner J, Möller A, Nugent PE, Prajs S, Thomas R, Wolf R, Zenteno A, Abbott TMC, Abdalla FB, Allam S, Annis J, Bechtol K, Benoit-Lévy A, Bertin E, Brooks D, Burke DL, Carnero Rosell A, Carrasco Kind M, Carretero J, Castander FJ, Crocce M, Cunha CE, Da Costa LN, Davis C, Desai S, Diehl HT, Doel P, Eifler TF, Flaugher B, Fosalba P, Frieman J, García-Bellido J, Gaztanaga E, Gerdes DW, Goldstein DA, Gruen D, Gruendl RA, Gschwend J, Gutierrez G, Honscheid K, James DJ, Johnson MWG, Kuehn K, Kuropatkin N, Li TS, Lima M, Maia MAG, Marshall JL, Martini P, Menanteau F, Miller CJ, Miquel R, Ogando RLC, Petravick D, Plazas AA, Romer AK, Rykoff ES, Sako M, Sanchez E, Scarpine V, Schindler R, Schubnell M, Sevilla-Noarbe I, Smith RC, Soares-Santos M, Sobreira F, Suchyta E, Swanson MEC, Tarle G, Walker ARet al., 2018, Studying the ultraviolet spectrum of the first spectroscopically confirmed supernova at redshift two, Astrophysical Journal, Vol: 854, ISSN: 0004-637X

We present observations of DES16C2nm, the first spectroscopically confirmed hydrogen-free superluminous supernova (SLSN-I) at redshift z ≊ 2. DES16C2nm was discovered by the Dark Energy Survey (DES) Supernova Program, with follow-up photometric data from the Hubble Space Telescope, Gemini, and the European Southern Observatory Very Large Telescope supplementing the DES data. Spectroscopic observations confirm DES16C2nm to be at z = 1.998, and spectroscopically similar to Gaia16apd (a SLSN-I at z = 0.102), with a peak absolute magnitude of U = -22.26 ± 0.06. The high redshift of DES16C2nm provides a unique opportunity to study the ultraviolet (UV) properties of SLSNe-I. Combining DES16C2nm with 10 similar events from the literature, we show that there exists a homogeneous class of SLSNe-I in the UV (λrest ≊ 2500 Å), with peak luminosities in the (rest-frame) U band, and increasing absorption to shorter wavelengths. There is no evidence that the mean photometric and spectroscopic properties of SLSNe-I differ between low (z < 1) and high redshift (z > 1), but there is clear evidence of diversity in the spectrum at λrest < 2000 Å, possibly caused by the variations in temperature between events. No significant correlations are observed between spectral line velocities and photometric luminosity. Using these data, we estimate that SLSNe-I can be discovered to z = 3.8 by DES. While SLSNe-I are typically identified from their blue observed colors at low redshift (z < 1), we highlight that at z > 2 these events appear optically red, peaking in the observer-frame z-band. Such characteristics are critical to identify these objects with future facilities such as the Large Synoptic Survey Telescope, Euclid, and the Wide-field Infrared Survey Telescope, which should detect such SLSNe-I to z = 3.5, 3.7, and 6.6, respectively.

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• Citations: 21

Sommerauer M, Fedorova TD, Hansen AK, Knudsen K, Otto M, Jeppesen J, Frederiksen Y, Blicher JU, Geday J, Nahimi A, Damholdt MF, Brooks DJ, Borghammer Pet al., 2018, Evaluation of the noradrenergic system in Parkinson's disease: an <SUP>11</SUP>C-MeNER PET and neuromelanin MRI study, BRAIN, Vol: 141, Pages: 496-504, ISSN: 0006-8950

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• Citations: 106

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang Jet al., 2018, Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting., Neurology, Vol: 90, Pages: 74-82

Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy. For each topic area, an expert served as a working group chair and each working group developed priority-ranked research recommendations with associated timelines and pathways to reach the intended goals. In this report, each groups' recommendations are provided.

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Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleo A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chetelat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, de Oliveira CR, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonca A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJet al., 2018, Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia, JAMA PSYCHIATRY, Vol: 75, Pages: 84-95, ISSN: 2168-622X

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• Citations: 105

Helmich RC, Vaillancourt DE, Brooks DJ, 2018, The Future of Brain Imaging in Parkinson's Disease, JOURNAL OF PARKINSONS DISEASE, Vol: 8, Pages: S47-S51, ISSN: 1877-7171

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• Citations: 20

Ismail R, Hansen AK, Parbo P, Brændgaard H, Gottrup H, Brooks DJ, Borghammer Pet al., 2018, The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease., Int J Alzheimers Dis, Vol: 2018, ISSN: 2090-8024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid-β (Aβ) and hyperphosphorylated tau. No effective disease modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Aβ load in transgenic mice. We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients. We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker. Six Aβ positive patients received 10 days of light therapy, had 2 hours of daily exposure, and underwent a postintervention PiB PET on day 11. After 10 days of light therapy, no significant decrease of PiB SUVR values was detected in any volumes of interest tested (primary visual cortex, visual association cortex, lateral parietal cortex, precuneus, and posterior cingulate) or in the total motor cortex, and longer treatments may be necessary to induce amyloid removal in humans.

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Edison P, Brooks DJ, 2018, Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and <i>in vivo</i> Quantification Using PET, ALZHEIMER'S DISEASE: NEW BEGINNINGS, Editors: Perry, Avila, Moreira, Sorensen, Tabaton, Publisher: IOS PRESS, Pages: 337-349, ISBN: 978-1-61499-875-4

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Politis M, Sauerbier A, Loane C, Pavese N, Martin A, Corcoran B, Brooks DJ, Ray-Chaudhuri K, Piccini Pet al., 2017, Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients, MOVEMENT DISORDERS, Vol: 32, Pages: 235-240, ISSN: 0885-3185

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Abbott BP, Abbott R, Abbott TD, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Adya VB, Affeldt C, Afrough M, Agarwal B, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P, Allen B, Allen G, Allocca A, Altin PA, Amato A, Ananyeva A, Anderson SB, Anderson WG, Angelova SV, Antier S, Appert S, Arai K, Araya MC, Areeda JS, Arnaud N, Arun KG, Ascenzi S, Ashton G, Ast M, Aston SM, Astone P, Atallah DV, Aufmuth P, Aulbert C, AultONeal K, Austin C, Avila-Alvarez A, Babak S, Bacon P, Bader MKM, Bae S, Baker PT, Baldaccini F, Ballardin G, Ballmer SW, Banagiri S, Barayoga JC, Barclay SE, Barish BC, Barker D, Barkett K, Barone F, Barr B, Barsotti L, Barsuglia M, Barta D, Barthelmy SD, Bartlett J, Bartos I, Bassiri R, Basti A, Batch JC, Bawaj M, Bayley JC, Bazzan M, Becsy B, Beer C, Bejger M, Belahcene I, Bell AS, Berger BK, Bergmann G, Bero JJ, Berry CPL, Bersanetti D, Bertolini A, Betzwieser J, Bhagwat S, Bhandare R, Bilenko IA, Billingsley G, Billman CR, Birch J, Birney R, Birnholtz O, Biscans S, Biscoveanu S, Bisht A, Bitossi M, Biwer C, Bizouard MA, Blackburn JK, Blackman J, Blair CD, Blair DG, Blair RM, Bloemen S, Bock O, Bode N, Boer M, Bogaert G, Bohe A, Bondu F, Bonilla E, Bonnand R, Boom BA, Bork R, Boschi V, Bose S, Bossie K, Bouffanais Y, Bozzi A, Bradaschia C, Brady PR, Branchesi M, Brau JE, Briant T, Brillet A, Brinkmann M, Brisson V, Brockill P, Broida JE, Brooks AF, Brown DA, Brown DD, Brunett S, Buchanan CC, Buikema A, Bulik T, Bulten HJ, Buonanno A, Buskulic D, Buy C, Byer RL, Cabero M, Cadonati L, Cagnoli G, Cahillane C, Bustillo JC, Callister TA, Calloni E, Camp JB, Canepa M, Canizares P, Cannon KC, Cao H, Cao J, Capano CD, Capocasa E, Carbognani F, Caride S, Carney MF, Diaz JC, Casentini C, Caudill S, Cavagli M, Cavalier F, Cavalieri R, Cella G, Cepeda CB, Cerd-Durn P, Cerretani G, Cesarini E, Chamberlin SJ, Chan M, Chao S, Charlton P, Chase E, Chassande-Mottin E, Chatterjee D, Chatziioannou K, Cheeseboro BD, Chen HY, Cheet al., 2017, Multi-messenger Observations of a Binary Neutron Star Merger, ASTROPHYSICAL JOURNAL LETTERS, Vol: 848, ISSN: 2041-8205

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• Citations: 1861

Stokholm MG, Iranzo A, Ostergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Moller A, Gaig C, Brooks DJ, Tolosa E, Pavese Net al., 2017, Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study, LANCET NEUROLOGY, Vol: 16, Pages: 789-796, ISSN: 1474-4422

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• Citations: 123

Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, Marras C, Tanner CM, Ross GW, Langston JW, Klein C, Bonifati V, Jankovic J, Lozano AM, Deuschl G, Bergman H, Tolosa E, Rodriguez-Violante M, Fahn S, Postuma RB, Berg D, Marek K, Standaert DG, Surmeier DJ, Olanow CW, Kordower JH, Calabresi P, Schapira AHV, Stoessl AJet al., 2017, Past, Present, and Future of Parkinson's Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy, MOVEMENT DISORDERS, Vol: 32, Pages: 1264-1310, ISSN: 0885-3185

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• Citations: 273

Politis M, Wilson H, Wu K, Brooks DJ, Piccini Pet al., 2017, Chronic exposure to dopamine agonists affects the integrity of striatal D2 receptors in Parkinson's patients., NeuroImage: Clinical, Vol: 16, Pages: 455-460, ISSN: 2213-1582

We aimed to investigate the integrity and clinical relevance of striatal dopamine receptor type-2 (D2R) availability in Parkinson's disease (PD) patients. We studied 68 PD patients, spanning from early to advanced disease stages, and 12 healthy controls. All participants received one [(11)C]raclopride PET scan in an OFF medication condition for quantification of striatal D2R availability in vivo. Parametric images of [(11)C]raclopride non-displaceable binding potential were generated from the dynamic [(11)C]raclopride scans using implementation of the simplified reference tissue model with cerebellum as the reference tissue. PET data were interrogated for correlations with clinical data related to disease burden and dopaminergic treatment. PD patients showed a mean 16.7% decrease in caudate D2R and a mean 3.5% increase in putaminal D2R availability compared to healthy controls. Lower caudate [(11)C]raclopride BPND correlated with longer PD duration. PD patients on dopamine agonist treatment had 9.2% reduced D2R availability in the caudate and 12.8% in the putamen compared to PD patients who never received treatment with dopamine agonists. Higher amounts of lifetime dopamine agonist therapy correlated with reduced D2Rs availability in both caudate and putamen. No associations between striatal D2R availability and levodopa treatment and dyskinesias were found. In advancing PD the caudate and putamen D2R availability are differentially affected. Chronic exposure to treatment with dopamine agonists, but no levodopa, suppresses striatal D2R availability, which may have relevance to output signaling to frontal lobes and the occurrence of executive deficits, but not dyskinesias.

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Lawson RA, Yarnall AJ, Duncan GW, Breen DP, Khoo TK, Williams-Gray CH, Barker RA, Burn DJet al., 2017, Stability of mild cognitive impairment in newly diagnosed Parkinson's disease, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 88, Pages: 648-652, ISSN: 0022-3050

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• Citations: 50

Fan Z, Femminella GD, Calsolaro V, Veronese M, Turkheimer F, Brooks DJ, Hinz R, Edison Pet al., 2017, Strategies to develop parametric maps for TSPO PET tracer [11C]-PBR28 in patients with mild cognitive impairment, Alzheimer's and Dementia, Vol: 13, Pages: P288-P289, ISSN: 1552-5260

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Dani M, Fan Z, Wood M, Mitzoguchi R, Morgan R, Walker Z, Femminella G, Calsolaro V, Brooks D, Edison Pet al., 2017, Amyloid deposition, tau aggregation and microglial activation correlate with vascular burden in vivo in Alzheimer's disease, Alzheimer's and Dementia, Vol: 13, Pages: P681-P682, ISSN: 1552-5260

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Femminella G, Dani M, Wood M, Fan Z, Calsolaro V, Mitzoguchi R, Atkinson RA, Edgington T, Waldman A, Hinz R, Brooks D, Edison Pet al., 2017, Microglial activation is associated with higher grey matter density and hippocampal volume in MCi subjects, Alzheimer's and Dementia, Vol: 13, Pages: P921-P921, ISSN: 1552-5260

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Calsolaro V, Fan Z, Femminella G, Veronese M, Pasqualetti G, Trigg W, Turkheimer F, Gentleman S, Brooks D, Hinz R, Edison P, Buckley Cet al., 2017, Microglial activation in Alzheimer’s disease detected by novel third generation translocator protein tracer flutriciclamide ([18F]GE180), Alzheimer's and Dementia, Vol: 13, Pages: P922-P922, ISSN: 1552-5260

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Dani M, Wood M, Mizoguchi R, Fan Z, Brooks D, Edison Pet al., 2017, Different modelling approaches for tau tracer 18F-AV1451 in mild cognitive impairment and Alzheimer's disease, Alzheimer's and Dementia, Vol: 13, Pages: P291-P292, ISSN: 1552-5260

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Collett TE, Buckley-Geer E, Lin H, Bacon D, Nichol RC, Nord B, Morice-Atkinson X, Amara A, Birrer S, Kuropatkin N, More A, Papovich C, Romer KK, Tessore N, Abbott TMC, Allam S, Annis J, Benoit-Lévy A, Brooks D, Burke DL, Carrasco Kind M, Castander FJJ, D'Andrea CB, Da Costa LN, Desai S, Diehl HT, Doel P, Eifler TF, Flaugher B, Frieman J, Gerdes DW, Goldstein DA, Gruen D, Gschwend J, Gutierrez G, James DJ, Kuehn K, Kuhlmann S, Lahav O, Li TS, Lima M, Maia MAG, March M, Marshall JL, Martini P, Melchior P, Miquel R, Plazas AA, Rykoff ES, Sanchez E, Scarpine V, Schindler R, Schubnell M, Sevilla-Noarbe I, Smith M, Sobreira F, Suchyta E, Swanson MEC, Tarle G, Tucker DL, Walker ARet al., 2017, Core or Cusps: The Central Dark Matter Profile of a Strong Lensing Cluster with a Bright Central Image at Redshift 1, Astrophysical Journal, Vol: 843, ISSN: 0004-637X

We report on SPT-CLJ2011-5228, a giant system of arcs created by a cluster at z = 1.06. The arc system is notable for the presence of a bright central image. The source is a Lyman break galaxy at z s = 2.39 and the mass enclosed within the Einstein ring of radius 14 arcsec is . We perform a full reconstruction of the light profile of the lensed images to precisely infer the parameters of the mass distribution. The brightness of the central image demands that the central total density profile of the lens be shallow. By fitting the dark matter as a generalized Navarro-Frenk-White profile - with a free parameter for the inner density slope - we find that the break radius is kpc, and that the inner density falls with radius to the power -0.38 ±0.04 at 68% confidence. Such a shallow profile is in strong tension with our understanding of relaxed cold dark matter halos; dark matter-only simulations predict that the inner density should fall as . The tension can be alleviated if this cluster is in fact a merger; a two-halo model can also reconstruct the data, with both clumps (density varying as and ) much more consistent with predictions from dark matter-only simulations. At the resolution of our Dark Energy Survey imaging, we are unable to choose between these two models, but we make predictions for forthcoming Hubble Space Telescope imaging that will decisively distinguish between them.

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• Citations: 21

Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Mollenhauer B, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O'Brien JTet al., 2017, Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease, NEUROBIOLOGY OF AGING, Vol: 55, Pages: 78-90, ISSN: 0197-4580

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• Citations: 35

Dani M, Brooks DJ, Edison P, 2017, Suspected non Alzheimer's pathology - Is it non-Alzheimer's or non-amyloid?, AGEING RESEARCH REVIEWS, Vol: 36, Pages: 20-31, ISSN: 1568-1637

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• Citations: 28