Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
//

Contact

 

david.brooks

 
 
//

Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
//

Location

 

U106Block B Hammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ismail:2018:2018/6852303,
author = {Ismail, R and Hansen, AK and Parbo, P and Brændgaard, H and Gottrup, H and Brooks, DJ and Borghammer, P},
doi = {2018/6852303},
journal = {Int J Alzheimers Dis},
title = {The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease.},
url = {http://dx.doi.org/10.1155/2018/6852303},
volume = {2018},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid-β (Aβ) and hyperphosphorylated tau. No effective disease modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Aβ load in transgenic mice. We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients. We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker. Six Aβ positive patients received 10 days of light therapy, had 2 hours of daily exposure, and underwent a postintervention PiB PET on day 11. After 10 days of light therapy, no significant decrease of PiB SUVR values was detected in any volumes of interest tested (primary visual cortex, visual association cortex, lateral parietal cortex, precuneus, and posterior cingulate) or in the total motor cortex, and longer treatments may be necessary to induce amyloid removal in humans.
AU  - Ismail,R
AU  - Hansen,AK
AU  - Parbo,P
AU  - Brændgaard,H
AU  - Gottrup,H
AU  - Brooks,DJ
AU  - Borghammer,P
DO  - 2018/6852303
PY  - 2018///
SN  - 2090-8024
TI  - The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease.
T2  - Int J Alzheimers Dis
UR  - http://dx.doi.org/10.1155/2018/6852303
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30155285
VL  - 2018
ER  -
Download