Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kübler:2019:10.1002/mds.27620,
author = {Kübler, D and Wächter, T and Cabanel, N and Su, Z and Turkheimer, FE and Dodel, R and Brooks, DJ and Oertel, WH and Gerhard, A},
doi = {10.1002/mds.27620},
journal = {Movement Disorders},
pages = {564--568},
title = {Widespread microglial activation in multiple system atrophy},
url = {http://dx.doi.org/10.1002/mds.27620},
volume = {34},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [11C](R)PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients.MethodsFourteen patients with the parkinsonian phenotype of MSA (MSAP) with a mean disease duration of 2.9 years (range 25 years) were examined with [11C](R)PK11195 PET and compared with 10 healthy controls.ResultsPatients with the parkinsonian phenotype of MSA showed a significant (P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cortex, and the superior parietal gyrus. No correlations between binding potentials and clinical parameters were found.ConclusionsIn early clinical stages of the parkinsonian phenotype of MSA, there is widespread microglial activation as a marker of neuroinflammatory changes without correlation to clinical parameters in our patient population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
AU  - Kübler,D
AU  - Wächter,T
AU  - Cabanel,N
AU  - Su,Z
AU  - Turkheimer,FE
AU  - Dodel,R
AU  - Brooks,DJ
AU  - Oertel,WH
AU  - Gerhard,A
DO  - 10.1002/mds.27620
EP  - 568
PY  - 2019///
SN  - 0885-3185
SP  - 564
TI  - Widespread microglial activation in multiple system atrophy
T2  - Movement Disorders
UR  - http://dx.doi.org/10.1002/mds.27620
UR  - http://hdl.handle.net/10044/1/72429
VL  - 34
ER  -
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