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@article{Schubert:2019:10.2967/jnumed.118.223834,
author = {Schubert, JJ and Veronese, M and Marchitelli, L and Bodini, B and Tonietto, M and Stankoff, B and Brooks, DJ and Bertoldo, A and Edison, P and Turkheimer, F},
doi = {10.2967/jnumed.118.223834},
journal = {Journal of Nuclear Medicine},
pages = {1452--1460},
title = {Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer's disease and multiple sclerosis},
url = {http://dx.doi.org/10.2967/jnumed.118.223834},
volume = {60},
year = {2019}
}

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TY  - JOUR
AB  - Cerebrospinal fluid (CSF) plays an important role in the clearance of solutes and maintenance of brain homeostasis. 11C-PiB PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer's disease. The current study seeks to investigate the magnitude of 11C-PiB PET signal in the lateral ventricles of an independent group of Alzheimer's and mild cognitive impairment subjects. We have also evaluated multiple sclerosis as a model of disease with CSF clearance alterations without amyloid-beta tissue accumulation. Methods: A set of Alzheimer's and mild cognitive impairment subjects and a set of multiple sclerosis subjects with matched healthy controls underwent MRI and dynamic 11C-PiB PET. Manual lateral ventricle regions of interest were generated from MRI data. PET data was analysed using a simplified reference tissue model with cerebellum or a supervised reference region, for the Alzheimer's and multiple sclerosis datasets, respectively. Magnitude of 11C-PiB signal in the lateral ventricles was calculated as area under curve from 35 to 80 minutes and standard uptake value ratio (SUVR) from 50 to 70 minutes. Compartmental modelling analysis was performed on a separate dataset containing Alzheimer's and matched healthy control data with an arterial input function to further understand the kinetics of the lateral ventricular 11C-PiB signal. Results: Analysis of variance revealed significant group differences in lateral ventricular SUVR across the Alzheimer's, mild cognitive impairment, and healthy control groups (P = 0.004). Additional pairwise comparisons revealed significantly lower lateral ventricular SUVR in Alzheimer's compared to healthy controls (p<0.001) and mild cognitive impairment (P = 0.029). Lateral ventricular SUVR was also significantly lower in multiple sclerosis compared to healthy controls (P = 0.008). Compartmental modelling analysis revealed significantly lower uptake rates of 11C-PiB signal from blood (P = 0.005) and b
AU  - Schubert,JJ
AU  - Veronese,M
AU  - Marchitelli,L
AU  - Bodini,B
AU  - Tonietto,M
AU  - Stankoff,B
AU  - Brooks,DJ
AU  - Bertoldo,A
AU  - Edison,P
AU  - Turkheimer,F
DO  - 10.2967/jnumed.118.223834
EP  - 1460
PY  - 2019///
SN  - 1535-5667
SP  - 1452
TI  - Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer's disease and multiple sclerosis
T2  - Journal of Nuclear Medicine
UR  - http://dx.doi.org/10.2967/jnumed.118.223834
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30850505
UR  - http://hdl.handle.net/10044/1/73855
VL  - 60
ER  -

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