Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Paquini:2019:10.1136/jnnp-2018-320157,
author = {Paquini, J and Durcan, R and Wiblin, L and Stokholm, MG and Rochester, L and Brooks, DJ and Burn, D and Pavese, N},
doi = {10.1136/jnnp-2018-320157},
journal = {Journal of Neurology, Neurosurgery and Psychiatry},
pages = {1098--1104},
title = {Clinical implications of early caudate dysfunction in Parkinson's disease},
url = {http://dx.doi.org/10.1136/jnnp-2018-320157},
volume = {90},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective Although not typical of Parkinson’s disease (PD), caudate dopaminergic dysfunction can occur in early stages of the disease. However, its frequency and longitudinal implications in large cohorts of recently diagnosed patients remain to be established. We investigated the occurrence of caudate dopaminergic dysfunction in the very early phases of PD (<2 years from diagnosis) using 123I-FP-CIT single photon emission CT and determined whether it was associated with the presence or subsequent development of cognitive impairment, depression, sleep and gait problems.Methods Patients with PD and healthy controls were identified from the Parkinson’s Progression Markers Initiative (PPMI) database. We defined a clinically significant caudate dysfunction as 123I-FP-CIT binding <–2 SDs compared with the controls’ mean and categorised three groups accordingly (no reduction, unilateral reduction, bilateral reduction). All statistical analyses were adjusted for mean putamen binding.Results At baseline, 51.6% of 397 patients had normal caudate dopamine transporter binding, 26.0% had unilateral caudate involvement, 22.4% had bilaterally impaired caudate.Compared with those with a baseline normal caudate function, at the4-year follow-up patients with a baseline bilateral caudate involvement showed a higher frequency of cognitive impairment (p<0.001) and depression (p<0.001), and worse cognitive (p<0.001), depression (<0.05) and gait (<0.001) ratings. Significant caudate involvement was observed in 83.9% of the population after 4 years (unilateral 22.5%, bilateral 61.4%).Conclusions Early significant caudate dopaminergic denervation was found in half of the cases in the PPMI series. Baseline bilateral caudate involvement was associated with increased risk of developing cognitive impairment, depression and gait problems over the next 4 years.
AU  - Paquini,J
AU  - Durcan,R
AU  - Wiblin,L
AU  - Stokholm,MG
AU  - Rochester,L
AU  - Brooks,DJ
AU  - Burn,D
AU  - Pavese,N
DO  - 10.1136/jnnp-2018-320157
EP  - 1104
PY  - 2019///
SN  - 1468-330X
SP  - 1098
TI  - Clinical implications of early caudate dysfunction in Parkinson's disease
T2  - Journal of Neurology, Neurosurgery and Psychiatry
UR  - http://dx.doi.org/10.1136/jnnp-2018-320157
UR  - https://jnnp.bmj.com/content/90/10/1098
UR  - http://hdl.handle.net/10044/1/70230
VL  - 90
ER  -
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