Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mansur:2020:10.2967/jnumed.119.228080,
author = {Mansur, A and Rabiner, EA and Comley, RA and Lewis, Y and Middleton, LT and Huiban, M and Passchier, J and Tsukada, H and Gunn, RN},
doi = {10.2967/jnumed.119.228080},
journal = {Journal of Nuclear Medicine},
pages = {96--103},
title = {Characterization of 3 PET tracers for Quantification of Mitochondrial and Synaptic function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J},
url = {http://dx.doi.org/10.2967/jnumed.119.228080},
volume = {61},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mitochondrial complex 1 (MC1) is involved in maintaining brain bioenergetics, the sigma 1 receptor (σ1R) responds to neuronal stress and synaptic vesicle protein 2A (SV2A) reflects synaptic integrity. Expression of each of these proteins is altered in neurodegenerative diseases. Here we characterise the kinetic behaviour of three positron emission tomography (PET) radioligands 18F-BCPP-EF, 11C-SA-4503 and 11CUCB- J, for the measurement of MC1, σ1R and SV2A, respectively, and determine appropriate analysis workflows for their application in future studies of the in vivo molecular pathology of these diseases. Methods: Twelve human subjects underwent dynamic PET scans including associated arterial blood sampling with each radioligand. A range of kinetic models were investigated to identify an optimal kinetic analysis method for each radioligand and a suitable acquisition duration. Results: All three radioligands readily entered the brain and yielded heterogeneous uptake consistent with the known distribution of the targets. The optimal models determined for the regional estimates of volume of distribution (VT) were multilinear analysis 1 (MA1) and the 2-tissue compartment (2TC) model for 18F-BCPP-EF, MA1 for 11C-SA- 4503, and both MA1 and the 1-tissue compartment (1TC) model for 11C-UCB-J. Acquisition times of 70, 80 and 60 minutes for 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J, respectively, provided good estimates of regional VT values. An effect of age was observed on 18F-BCPP-EF and 11C-UCB-J signal in the caudate. Conclusion: These ligands can be assessed for their potential to stratify patients or monitor the progression of molecular neuropathology in neurodegenerative diseases.
AU  - Mansur,A
AU  - Rabiner,EA
AU  - Comley,RA
AU  - Lewis,Y
AU  - Middleton,LT
AU  - Huiban,M
AU  - Passchier,J
AU  - Tsukada,H
AU  - Gunn,RN
DO  - 10.2967/jnumed.119.228080
EP  - 103
PY  - 2020///
SN  - 1535-5667
SP  - 96
TI  - Characterization of 3 PET tracers for Quantification of Mitochondrial and Synaptic function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J
T2  - Journal of Nuclear Medicine
UR  - http://dx.doi.org/10.2967/jnumed.119.228080
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31324712
UR  - http://hdl.handle.net/10044/1/76541
VL  - 61
ER  -
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