Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hansen:2020:10.3233/JPD-191774,
author = {Hansen, AK and Parbo, P and Ismail, R and Østergaard, K and Brooks, DJ and Borghammer, P},
doi = {10.3233/JPD-191774},
journal = {Journal of Parkinsons Disease},
pages = {161--171},
title = {Tau tangles in Parkinson's disease: A 2-year follow-up flortaucipir PET study.},
url = {http://dx.doi.org/10.3233/JPD-191774},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Flortaucipir PET, a marker of tau tangles, has shown lower than expected cortical uptake in Parkinson's disease (PD), than would be predicted from neuropathologic estimates of Alzheimer's disease co-pathology. Instead, the most characteristic finding of flortaucipir imaging in PD is decreased uptake in the substantia nigra, reflecting reduction in its "off-target" binding to neuromelanin. We have previously reported these observations in cross-sectional studies. OBJECTIVE: Here, we present two-year follow-up data of cortical and nigral flortaucipir uptake in PD patients. METHODS: Seventeen PD patients received repeat flortaucipir PET two years after baseline. We interrogated vertex-based group-wise cortical tracer binding (SUVRs) with a cerebellar reference using the general linear model while mean substantia nigra SUVRs were compared with volumes of interest group comparisons and voxel-wise group analyses using ANOVA. Finally, we performed linear regressions of tau load with changes in MoCA and UPDRS motor scores. RESULTS: We found no significant changes in substantia nigra or cortex flortaucipir uptake in Parkinson's disease patients over two years and no association with changes in cognitive symptoms. Signal reduction in the medial substantia nigra trended towards an association with worsening of motor symptoms. CONCLUSION: No significant increase in tau tangles occurred after a two-year follow-up of Parkinson's disease patients using flortaucipir PET.
AU  - Hansen,AK
AU  - Parbo,P
AU  - Ismail,R
AU  - Østergaard,K
AU  - Brooks,DJ
AU  - Borghammer,P
DO  - 10.3233/JPD-191774
EP  - 171
PY  - 2020///
SN  - 1877-718X
SP  - 161
TI  - Tau tangles in Parkinson's disease: A 2-year follow-up flortaucipir PET study.
T2  - Journal of Parkinsons Disease
UR  - http://dx.doi.org/10.3233/JPD-191774
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31815700
UR  - https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd191774
UR  - http://hdl.handle.net/10044/1/75673
VL  - 10
ER  -
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