Imperial College London

ProfessorDavidCarling

Faculty of MedicineInstitute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 3313 4313david.carling

 
 
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Location

 

3rd Fl CRBHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

154 results found

Sag D, Carling D, Stout RD, Suttles Jet al., 2008, Adenosine 5 '-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 8633-8641, ISSN: 0022-1767

Journal article

Carling D, Sanders MJ, Woods A, 2008, The regulation of AMP-activated protein kinase by upstream kinases, INTERNATIONAL JOURNAL OF OBESITY, Vol: 32, Pages: S55-S59, ISSN: 0307-0565

Journal article

Thornton C, Sardini A, Carling D, 2008, Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 17116-17122

Journal article

Lopez M, Lage R, Saha AK, Perez-Tilve D, Vazquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodriguez-Cuenca S, Deoliveira RM, Castaneda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschop MH, Dieguez C, Vidal-Puig Aet al., 2008, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin, CELL METABOLISM, Vol: 7, Pages: 389-399, ISSN: 1550-4131

Journal article

Bright NJ, Carling D, Thornton C, 2008, Investigating the regulation of brain specific kinases 1 and 2 by phosphorylation, J. Biol. Chem., Vol: 283, Pages: 14946-14954

Journal article

Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong Y-C, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, Combs TPet al., 2007, Low utilization of circulating glucose after food withdrawal in Snell dwarf mice, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 35069-35077

Journal article

Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling Det al., 2007, Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 32539-32548

Journal article

Oliveira SM, Zhang Y-H, Davies J, Carling D, Casadei B, Watkins H, Redwood Cet al., 2007, AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility in murine ventricular myocytes, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 304-305, ISSN: 0009-7322

Conference paper

Stocker C, Wargent E, O'Dowd J, Ngala R, Carling D, Arch J, Cawthorne Met al., 2007, Patterns of postnatal growth impact on the early life programming of energy balance, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S113-S114, ISSN: 0378-3782

Journal article

Dranchak PK, Leiper FC, Valberg SJ, Piercy RJ, Carling D, McCue ME, Mickelson JRet al., 2007, Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses, AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol: 68, Pages: 1079-1084, ISSN: 0002-9645

Journal article

Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, Gamblin SJet al., 2007, Structural basis for AMP binding to mammalian AMP-activated protein kinase, NATURE, Vol: 449, Pages: 496-U14, ISSN: 0028-0836

Journal article

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LGD, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford MLJ, Carling D, Withers DJet al., 2007, AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 2325-2336, ISSN: 0021-9738

Journal article

Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, Miraux S, Thiaudiere E, Foretz M, Viollet B, Diolez P, Bastin J, Benit P, Rustin P, Carling D, Sandri M, Ventuar-Clapier R, Pende Met al., 2007, S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase, CELL METABOLISM, Vol: 5, Pages: 476-487, ISSN: 1550-4131

Journal article

Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz Pet al., 2007, A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 16117-16125

Journal article

Cheng KKY, Lam KSL, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu Aet al., 2007, Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells., Diabetes, Vol: 56, Pages: 1387-1394

Adiponectin protects the vascular system partly through stimulation of endothelial nitric oxide (NO) production and endothelium-dependent vasodilation. The current study investigated the role of two recently identified adiponectin receptors, AdipoR1 and -R2, and their downstream effectors in mediating the endothelium actions of adiponectin. In human umbilical vein endothelial cells, adiponectin-induced phosphorylation of endothelial NO synthase (eNOS) at Ser(1177) and NO production were abrogated when expression of AdipoR1 and -R2 were simultaneously suppressed. Proteomic analysis demonstrated that the cytoplasmic tails of both AdipoR1 and -R2 interacted with APPL1, an adaptor protein that contains a PH (pleckstrin homology) domain, a PTB (phosphotyrosine-binding) domain, and a Leucine zipper motif. Suppression of APPL1 expression by RNA interference significantly attenuated adiponectin-induced phosphorylation of AMP-activated protein kinase (AMPK) at Thr(172) and eNOS at Ser(1177), and the complex formation between eNOS and heat shock protein 90, resulting in a marked reduction of NO production. Adenovirus-mediated overexpression of a constitutively active version of AMPK reversed these changes. In db/db diabetic mice, both APPL1 expression and adiponectin-induced vasodilation were significantly decreased compared with their lean littermates. Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation.

Journal article

Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling Det al., 2007, Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade, BIOCHEMICAL JOURNAL, Vol: 403, Pages: 139-148, ISSN: 0264-6021

Journal article

Carling D, 2007, AMP-activated protein kinase and the regulation of energy metabolism, Experimental Biology 2007 Annual Meeting, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: A206-A206, ISSN: 0892-6638

Conference paper

Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, Cooper E, Smart TG, Pangalos MN, Moss SJet al., 2007, Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase, NEURON, Vol: 53, Pages: 233-247, ISSN: 0896-6273

Journal article

Oliveira SM, Davies J, Carling D, Watkins H, Redwood Cet al., 2007, Cardiac troponin I is a potential novel substrate for AMP-activated protein kinase, 51st Annual Meeting of the Biophysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 180A-180A, ISSN: 0006-3495

Conference paper

Carling D, 2007, The role of the AMP-activated protein kinase in the regulation of energy homeostasis., Novartis Found Symp, Vol: 286, Pages: 72-81, ISSN: 1528-2511

AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that plays a major role in maintaining energy homeostasis. Within individual cells, AMPK is activated by a rise in the AMP:ATP ratio that occurs following a fall in ATP levels. AMPK is also regulated by the adipokines, adiponectin and leptin, hormones that are secreted from adipocytes. Activation of AMPK requires phosphorylation of threonine 172 within the catalytic subunit by either LKB1 or calcium/calmodulin dependent protein kinase kinase beta (CaMKKbeta). AMPK regulates a wide range of metabolic pathways, including fatty acid oxidation, fatty acid synthesis, glycolysis and gluconeogenesis. In peripheral tissues, activation of AMPK leads to responses that are beneficial in counteracting the deleterious effects that arise in the metabolic syndrome. Recent studies have demonstrated that modulation of AMPK activity in the hypothalamus plays a role in feeding. A decrease in hypothalamic AMPK activity is associated with decreased feeding, whereas activation of AMPK leads to increased food intake. Furthermore, signalling pathways in the hypothalamus lead to changes in AMPK activity in peripheral tissues, such as skeletal muscle, via the sympathetic nervous system (SNS). AMPK, therefore, provides a mechanism for monitoring changes in energy metabolism within individual cells and at the level of the whole body.

Journal article

Steinberg GR, Michell BJ, van Denderen BJW, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Gorgun CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BEet al., 2006, Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling, CELL METABOLISM, Vol: 4, Pages: 465-474, ISSN: 1550-4131

Journal article

Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LHet al., 2006, Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 291, Pages: H1927-H1934, ISSN: 0363-6135

Journal article

Stahmann N, Woods A, Carling D, Heller Ret al., 2006, Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta, MOLECULAR AND CELLULAR BIOLOGY, Vol: 26, Pages: 5933-5945, ISSN: 0270-7306

Journal article

Davies JK, Wells DJ, Liu K, Whitrow HR, Daniel TD, Grignani R, Lygate CA, Schneider JE, Noel G, Watkins H, Carling Det al., 2006, Characterization of the role of gamma 2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 290, Pages: H1942-H1951, ISSN: 0363-6135

Journal article

Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, Steinberg GRet al., 2006, CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK, NATURE MEDICINE, Vol: 12, Pages: 541-548, ISSN: 1078-8956

Journal article

Carling D, 2006, LKB1: a sweet side to Peutz-Jeghers syndrome?, TRENDS IN MOLECULAR MEDICINE, Vol: 12, Pages: 144-147, ISSN: 1471-4914

Journal article

Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Walliman T, Carling D, Hue L, Rider MHet al., 2006, Insulin antagonizes ischemia-induced Thr(172) phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser(485/491), JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 5335-5340

Journal article

Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling Det al., 2005, Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells, CELL METABOLISM, Vol: 2, Pages: 21-33, ISSN: 1550-4131

Journal article

Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D, Richter EAet al., 2005, Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 329, Pages: 719-725, ISSN: 0006-291X

Journal article

Fryer LGD, Carling D, 2005, AMP-activated protein kinase and the metabolic syndrome, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 33, Pages: 362-366, ISSN: 0300-5127

Journal article

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