Imperial College London

ProfessorDavidCarling

Faculty of MedicineInstitute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 3313 4313david.carling

 
 
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Location

 

3rd Fl CRBHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

154 results found

Sidhu JS, Rajawat YS, Rami TG, Gollob MH, Wang ZN, Yuan RY, Marian AJ, DeMayo FJ, Weilbacher D, Taffet GE, Davies JK, Carling D, Khoury DS, Roberts Ret al., 2005, Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome, CIRCULATION, Vol: 111, Pages: 21-29, ISSN: 0009-7322

Journal article

Kahn BB, Alquier T, Carling D, Hardie DGet al., 2005, AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism, CELL METABOLISM, Vol: 1, Pages: 15-25, ISSN: 1550-4131

Journal article

Carling D, 2005, AMP-activated protein kinase: balancing the scales, BIOCHIMIE, Vol: 87, Pages: 87-91, ISSN: 0300-9084

Journal article

Small CJ, Carling D, Bloom SR, 2004, Cellular energy sensor balances the scales, NATURE MEDICINE, Vol: 10, Pages: 681-682, ISSN: 1078-8956

Journal article

Clark H, Carling D, Saggerson D, 2004, Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 271, Pages: 2215-2224, ISSN: 0014-2956

Journal article

Cheng SWY, Fryer LGD, Carling D, Shepherd PRet al., 2004, Thr(2446) is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 15719-15722, ISSN: 0021-9258

Journal article

Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJet al., 2004, AMP-activated protein kinase plays a role in the control of food intake, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 12005-12008, ISSN: 0021-9258

Journal article

Canto C, Suarez E, Lizcano JM, Grino E, Shepherd PR, Fryer LGD, Carling D, Bertran J, Palacin M, Zorzano A, Guma Aet al., 2004, Neuregulin signaling on glucose transport in muscle cells, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 12260-12268, ISSN: 0021-9258

Journal article

Carling D, 2004, AMPK, CURRENT BIOLOGY, Vol: 14, Pages: R220-R220, ISSN: 0960-9822

Journal article

Carling D, 2004, AMPK., Curr Biol, Vol: 14, ISSN: 0960-9822

Journal article

Carling D, 2004, The AMP-activated protein kinase cascade - a unifying system for energy control, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 29, Pages: 18-24, ISSN: 0968-0004

Journal article

Carling D, Fryer LGD, Woods A, Daniel T, Jarvie SLC, Whitrow Het al., 2003, Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 31, Pages: 1157-1160, ISSN: 0300-5127

Journal article

Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LGD, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling Det al., 2003, LKB1 is the upstream kinase in the AMP-activated protein kinase cascade, CURRENT BIOLOGY, Vol: 13, Pages: 2004-2008, ISSN: 0960-9822

Journal article

Sidhu J, Gollob MJ, Yuan RY, Wang ZN, Appleton GO, Yi L, DeMayo FJ, Carling D, Khoury DS, Roberts Ret al., 2003, Transgenic mouse model of Wolff-parkinson-white syndrome with inducible supraventricular tachycardia generated by expressing the human AMPK mutation Arg302Glu, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 119-119, ISSN: 0009-7322

Conference paper

Neumann D, Woods A, Carling D, Wallimann T, Schlattner Uet al., 2003, Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli, PROTEIN EXPRESSION AND PURIFICATION, Vol: 30, Pages: 230-237, ISSN: 1046-5928

Journal article

Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carlling D, Rider MHet al., 2003, Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 28434-28442, ISSN: 0021-9258

Journal article

Hong SP, Leiper FC, Woods A, Carling D, Carlson Met al., 2003, Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 8839-8843, ISSN: 0027-8424

Journal article

Wang WG, Yang XL, de Silanes IL, Carling D, Gorospe Met al., 2003, Increased AMP : ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 27016-27023, ISSN: 0021-9258

Journal article

Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Yet al., 2003, Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 31, Pages: 202-206, ISSN: 0300-5127

Journal article

Yu M, Stepto NK, Chibalin AV, Fryer LGD, Carling D, Krook A, Hawley JA, Zierath JRet al., 2003, Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise., J Physiol, Vol: 546, Pages: 327-335, ISSN: 0022-3751

We determined whether mitogen-activated protein kinase (MAPK) and 5'-AMP-activated protein kinase (AMPK) signalling cascades are activated in response to intense exercise in skeletal muscle from six highly trained cyclists (peak O(2) uptake (.V(O2,peak)) 5.14 +/- 0.1 l min(-1)) and four control subjects (Vdot;(O(2))(,peak) 3.8 +/- 0.1 l min(-1)) matched for age and body mass. Trained subjects completed eight 5 min bouts of cycling at approximately 85% of .V(O2,peak) with 60 s recovery between work bouts. Control subjects performed four 5 min work bouts commencing at the same relative, but a lower absolute intensity, with a comparable rest interval. Vastus lateralis muscle biopsies were taken at rest and immediately after exercise. Extracellular regulated kinase (ERK1/2), p38 MAPK, histone H3, AMPK and acetyl CoA-carboxylase (ACC) phosphorylation was determined by immunoblot analysis using phosphospecific antibodies. Activity of mitogen and stress-activated kinase 1 (MSK1; a substrate of ERK1/2 and p38 MAPK) and alpha(1) and alpha(2) subunits of AMPK were determined by immune complex assay. ERK1/2 and p38 MAPK phosphorylation and MSK1 activity increased (P < 0.05) after exercise 2.6-, 2.1- and 2.0-fold, respectively, in control subjects and 1.5-, 1.6- and 1.4-fold, respectively, in trained subjects. Phosphorylation of histone H3, a substrate of MSK1, increased (P < 0.05) approximately 1.8-fold in both control and trained subject. AMPKalpha(2) activity increased (P < 0.05) after exercise 4.2- and 2.3-fold in control and trained subjects, respectively, whereas AMPKalpha(1) activity was not altered. Exercise increased ACC phosphorylation (P < 0.05) 1.9- and 2.8-fold in control and trained subjects. In conclusion, intense cycling exercise in subjects with a prolonged history of endurance training increases MAPK signalling to the downstream targets MSK1 and histone H3 and isoform-specific AMPK signalling to ACC. Importantly, exercise-induced signalling respons

Journal article

Viollet B, Andreelli F, Jorgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JFP, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont Set al., 2003, The AMP-activated protein kinase alpha 2 catalytic subunit controls whole-body insulin sensitivity, JOURNAL OF CLINICAL INVESTIGATION, Vol: 111, Pages: 91-98, ISSN: 0021-9738

Journal article

Halse R, Fryer LGD, McCormack JG, Carling D, Yeaman SJet al., 2003, Regulation of glycogen synthase by glucose and glycogen - A possible role for AMP-activated protein kinase, DIABETES, Vol: 52, Pages: 9-15, ISSN: 0012-1797

Journal article

Daniel T, Carling D, 2002, Functional analysis of mutations in the gamma(2) subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 51017-51024, ISSN: 0021-9258

Journal article

Salgado APC, Schuller D, Casal M, Leao C, Leiper FC, Carling D, Fietto LG, Tropia MJ, Castro IM, Brandao RLet al., 2002, Relationship between protein kinase C and derepression of different enzymes, FEBS LETTERS, Vol: 532, Pages: 324-332, ISSN: 0014-5793

Journal article

Fryer LGD, Parbu-Patel A, Carling D, 2002, Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4 imidazolecarboxamide riboside, FEBS LETTERS, Vol: 531, Pages: 189-192, ISSN: 0014-5793

Journal article

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki Tet al., 2002, Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase, NATURE MEDICINE, Vol: 8, Pages: 1288-1295, ISSN: 1078-8956

Journal article

Barnes BR, Ryder JW, Steiler TL, Fryer LGD, Carling D, Zierath JRet al., 2002, Isoform-specific regulation of 5 ' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction, DIABETES, Vol: 51, Pages: 2703-2708, ISSN: 0012-1797

Journal article

Fryer LGD, Parbu-Patel A, Carling D, 2002, The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 25226-25232, ISSN: 0021-9258

Journal article

Barnes K, Ingram JC, Porras OH, Barros LF, Hudson ER, Fryer LGD, Foufelle F, Carling D, Hardie DG, Baldwin SAet al., 2002, Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK), JOURNAL OF CELL SCIENCE, Vol: 115, Pages: 2433-2442, ISSN: 0021-9533

Journal article

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