Imperial College London

ProfessorDavidCarling

Faculty of MedicineInstitute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 3313 4313david.carling

 
 
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Location

 

3rd Fl CRBHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

154 results found

Wang W, Fan J, Yang X, Furer-Galban S, de Silanes IL, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe Met al., 2002, AMP-activated kinase regulates cytoplasmic HuR, MOLECULAR AND CELLULAR BIOLOGY, Vol: 22, Pages: 3425-3436, ISSN: 0270-7306

Journal article

Fryer LGD, Foufelle F, Barnes K, Baldwin SA, Woods A, Carling Det al., 2002, Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells, BIOCHEMICAL JOURNAL, Vol: 363, Pages: 167-174, ISSN: 0264-6021

Journal article

Minokoshi Y, Kim YB, Peroni OD, Fryer LGD, Muller C, Carling D, Kahn BBet al., 2002, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, NATURE, Vol: 415, Pages: 339-343, ISSN: 0028-0836

Journal article

Ido Y, Carling D, Ruderman N, 2002, Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells - Inhibition by the AMP-activated protein kinase activation, DIABETES, Vol: 51, Pages: 159-167, ISSN: 0012-1797

Journal article

Brandao RL, Etchebehere L, Queiroz CC, Tropia MJ, Ernandes JR, Goncalves T, Loureiro-Dias MC, Winderickx J, Thevelein JM, Leiper FC, Carling D, Castro IMet al., 2002, Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2, FEMS Yeast Res, Vol: 2, Pages: 93-102, ISSN: 1567-1356

Journal article

Jarvie S, Bayliss J, Carling D, 2001, Investigation of amp-activated protein kinase gamma subunit isoforms, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 33, Pages: A170-A170, ISSN: 0022-2828

Journal article

Fryer LGD, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, Carling Det al., 2000, Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase, DIABETES, Vol: 49, Pages: 1978-1985, ISSN: 0012-1797

Journal article

Coven DL, Hu XY, Sinusas AJ, Bergeron R, Carling D, Young LHet al., 2000, Activation of both alpha(1) and alpha(2) isoforms of AMP-activated protein kinase (AMPK) occurs during in vivo myocardial ischemia., CIRCULATION, Vol: 102, Pages: 344-344, ISSN: 0009-7322

Journal article

Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue Let al., 2000, Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia, CURRENT BIOLOGY, Vol: 10, Pages: 1247-1255, ISSN: 0960-9822

Journal article

Woods A, Azzout-Marniche D, Foretz M, Stein SC, Lemarchand P, Ferre P, Foufelle F, Carling Det al., 2000, Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase, MOLECULAR AND CELLULAR BIOLOGY, Vol: 20, Pages: 6704-6711, ISSN: 0270-7306

Journal article

Cheung PCF, Salt IP, Davies SP, Hardie DG, Carling Det al., 2000, Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding, BIOCHEMICAL JOURNAL, Vol: 346, Pages: 659-669, ISSN: 0264-6021

Journal article

Stein SC, Woods A, Jones NA, Davison MD, Carling Det al., 2000, The regulation of AMP-activated protein kinase by phosphorylation, BIOCHEMICAL JOURNAL, Vol: 345, Pages: 437-443, ISSN: 0264-6021

Journal article

Blazquez C, Woods A, de Ceballos ML, Carling D, Guzman Met al., 1999, The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes, JOURNAL OF NEUROCHEMISTRY, Vol: 73, Pages: 1674-1682, ISSN: 0022-3042

Journal article

Smith FC, Davies SP, Wilson WA, Carling D, Hardie DGet al., 1999, The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1, FEBS LETTERS, Vol: 453, Pages: 219-223, ISSN: 0014-5793

Journal article

Blazquez C, Woods A, de Ceballos ML, Carling D, Guzman Met al., 1999, The AMP-activated protein kinase sustains ketone body production by astrocytes during hypoxia, JOURNAL OF NEUROCHEMISTRY, Vol: 73, Pages: S216-S216, ISSN: 0022-3042

Journal article

Velasco G, del Pulgar TG, Carling D, Guzman Met al., 1998, Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components, FEBS LETTERS, Vol: 439, Pages: 317-320, ISSN: 0014-5793

Journal article

Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DGet al., 1998, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha 2 isoform, BIOCHEMICAL JOURNAL, Vol: 334, Pages: 177-187, ISSN: 0264-6021

Journal article

Foretz M, Carling D, Guichard C, Ferre P, Foufelle Fet al., 1998, AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 273, Pages: 14767-14771, ISSN: 0021-9258

Journal article

Thornton C, Snowden MA, Carling D, 1998, Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 273, Pages: 12443-12450, ISSN: 0021-9258

Journal article

Ponticos M, Lu OL, Morgan JE, Hardie DG, Partridge TA, Carling Det al., 1998, Dual regulation of AMP-activated protein kinase and the control of creatine kinase in skeletal muscle., FASEB JOURNAL, Vol: 12, Pages: A1408-A1408, ISSN: 0892-6638

Journal article

Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling Det al., 1998, Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle, EMBO JOURNAL, Vol: 17, Pages: 1688-1699, ISSN: 0261-4189

Journal article

Hardie DG, Carling D, Carlson M, 1998, The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?, ANNUAL REVIEW OF BIOCHEMISTRY, Vol: 67, Pages: 821-855, ISSN: 0066-4154

Journal article

Thornton C, Snowden MA, Carling D, 1997, Identification of a novel AMPK beta subunit that is highly expressed in skeletal muscle, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: S667-S667, ISSN: 0300-5127

Journal article

Carling D, Woods A, Thornton C, Cheung PCF, Smith FC, Ponticos M, Stein SCet al., 1997, Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: 1224-1228, ISSN: 0300-5127

Journal article

Hardie DG, Carling D, 1997, The AMP-activated protein kinase - Fuel gauge of the mammalian cell?, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 246, Pages: 259-273, ISSN: 0014-2956

Journal article

Woods A, Salt I, Scott J, Hardie DG, Carling Det al., 1996, The alpha 1 and alpha 2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro, FEBS LETTERS, Vol: 397, Pages: 347-351, ISSN: 0014-5793

Journal article

Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DGet al., 1996, Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 27879-27887, ISSN: 0021-9258

Journal article

Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK, Carling Det al., 1996, Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro., J Biol Chem, Vol: 271, Pages: 10282-10290, ISSN: 0021-9258

There is growing evidence that mammalian AMP-activated protein kinase (AMPK) plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. The active form of AMPK from rat liver exists as a heterotrimeric complex and we have previously shown that the catalytic subunit is structurally and functionally related to the SNF1 protein kinase from Saccharomyces cerevisiae. Here we describe the isolation and characterization of the two other polypeptides, termed AMPKbeta and AMPKgamma, that together with the catalytic subunit (AMPKalpha) form the active kinase complex in mammalian liver. Sequence analysis of cDNA clones encoding these subunits reveals that they are related to yeast proteins that interact with SNF1, providing further evidence that the regulation and function of AMPK and SNF1 have been conserved throughout evolution. The amino acid sequence of the beta subunit is most closely related to SIP2 (35% identity), while the amino acid sequence of the gamma subunit is 35% identical with SNF4. We show that both AMPKbeta and AMPKgamma mRNA and protein are expressed widely in rat tissues. We show that AMPKbeta interacts with both AMPKalpha and AMPKgamma in vitro, whereas AMPKalpha does not interact with AMPKgamma under the same conditions. These results suggest that AMPKbeta mediates the association of the heterotrimeric AMPK complex in vitro, and will facilitate future studies aimed at investigating the regulation of AMPK in vivo.

Journal article

HAWLEY SA, SELBERT MA, GOLDSTEIN EG, EDELMAN AM, CARLING D, HARDIE DGet al., 1995, 5'-AMP ACTIVATES THE AMP-ACTIVATED PROTEIN-KINASE CASCADE AND CA2+/CALMODULIN ACTIVATES THE CALMODULIN-DEPENDENT PROTEIN-KINASE-I CASCADE, VIA 3 INDEPENDENT MECHANISMS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 27186-27191, ISSN: 0021-9258

Journal article

VERHOEVEN AJM, WOODS A, BRENNAN CH, HAWLEY SA, HARDIE DG, SCOTT J, BERI RK, CARLING Det al., 1995, THE AMP-ACTIVATED PROTEIN-KINASE GENE IS HIGHLY EXPRESSED IN RAT SKELETAL-MUSCLE - ALTERNATIVE SPLICING AND TISSUE DISTRIBUTION OF THE MESSENGER-RNA, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 228, Pages: 236-243, ISSN: 0014-2956

Journal article

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