Imperial College London

ProfessorDavidCarling

Faculty of MedicineInstitute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 3313 4313david.carling

 
 
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Location

 

3rd Fl CRBHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

196 results found

Stein SC, Woods A, Jones NA, Davison MD, Carling Det al., 2000, The regulation of AMP-activated protein kinase by phosphorylation, BIOCHEMICAL JOURNAL, Vol: 345, Pages: 437-443, ISSN: 0264-6021

Journal article

Blazquez C, Woods A, de Ceballos ML, Carling D, Guzman Met al., 1999, The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes, JOURNAL OF NEUROCHEMISTRY, Vol: 73, Pages: 1674-1682, ISSN: 0022-3042

Journal article

Smith FC, Davies SP, Wilson WA, Carling D, Hardie DGet al., 1999, The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1, FEBS LETTERS, Vol: 453, Pages: 219-223, ISSN: 0014-5793

Journal article

Blazquez C, Woods A, de Ceballos ML, Carling D, Guzman Met al., 1999, The AMP-activated protein kinase sustains ketone body production by astrocytes during hypoxia, JOURNAL OF NEUROCHEMISTRY, Vol: 73, Pages: S216-S216, ISSN: 0022-3042

Journal article

Velasco G, del Pulgar TG, Carling D, Guzman Met al., 1998, Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components, FEBS LETTERS, Vol: 439, Pages: 317-320, ISSN: 0014-5793

Journal article

Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DGet al., 1998, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha 2 isoform, BIOCHEMICAL JOURNAL, Vol: 334, Pages: 177-187, ISSN: 0264-6021

Journal article

Foretz M, Carling D, Guichard C, Ferre P, Foufelle Fet al., 1998, AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 273, Pages: 14767-14771, ISSN: 0021-9258

Journal article

Thornton C, Snowden MA, Carling D, 1998, Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 273, Pages: 12443-12450, ISSN: 0021-9258

Journal article

Ponticos M, Lu OL, Morgan JE, Hardie DG, Partridge TA, Carling Det al., 1998, Dual regulation of AMP-activated protein kinase and the control of creatine kinase in skeletal muscle., FASEB JOURNAL, Vol: 12, Pages: A1408-A1408, ISSN: 0892-6638

Journal article

Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling Det al., 1998, Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle, EMBO JOURNAL, Vol: 17, Pages: 1688-1699, ISSN: 0261-4189

Journal article

Hardie DG, Carling D, Carlson M, 1998, The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?, ANNUAL REVIEW OF BIOCHEMISTRY, Vol: 67, Pages: 821-855, ISSN: 0066-4154

Journal article

Carling D, Woods A, Thornton C, Cheung PCF, Smith FC, Ponticos M, Stein SCet al., 1997, Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: 1224-1228, ISSN: 0300-5127

Journal article

Thornton C, Snowden MA, Carling D, 1997, Identification of a novel AMPK beta subunit that is highly expressed in skeletal muscle, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: S667-S667, ISSN: 0300-5127

Journal article

Cheung PCF, Carling D, 1997, Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues, 662nd Meeting of the Biochemical-Society, Publisher: PORTLAND PRESS, Pages: S668-S668, ISSN: 0300-5127

Conference paper

Hardie DG, Carling D, 1997, The AMP-activated protein kinase - Fuel gauge of the mammalian cell?, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 246, Pages: 259-273, ISSN: 0014-2956

Journal article

Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TWet al., 1997, Identification of Raf-1 Ser(621) kinase activity from NIH 3T3 cells as AMP-activated protein kinase, FEBS LETTERS, Vol: 403, Pages: 254-258, ISSN: 0014-5793

Journal article

Marley AE, Sullivan JE, Carling D, Abbott WM, Smith GJ, Taylor IWF, Carey F, Beri RKet al., 1996, Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha, BIOCHEMICAL JOURNAL, Vol: 320, Pages: 801-806, ISSN: 0264-6021

Journal article

Woods A, Salt I, Scott J, Hardie DG, Carling Det al., 1996, The alpha 1 and alpha 2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro, FEBS LETTERS, Vol: 397, Pages: 347-351, ISSN: 0014-5793

Journal article

Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DGet al., 1996, Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 27879-27887, ISSN: 0021-9258

Journal article

Woods A, Cheung PCF, Smith FC, Davison MD, Scott J, Beri RK, Carling Det al., 1996, Characterization of AMP-activated protein kinase beta and gamma subunits - Assembly of the heterotrimeric complex in vitro, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 10282-10290, ISSN: 0021-9258

Journal article

HAWLEY SA, SELBERT MA, GOLDSTEIN EG, EDELMAN AM, CARLING D, HARDIE DGet al., 1995, 5'-AMP ACTIVATES THE AMP-ACTIVATED PROTEIN-KINASE CASCADE AND CA2+/CALMODULIN ACTIVATES THE CALMODULIN-DEPENDENT PROTEIN-KINASE-I CASCADE, VIA 3 INDEPENDENT MECHANISMS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 27186-27191, ISSN: 0021-9258

Journal article

VERHOEVEN AJM, WOODS A, BRENNAN CH, HAWLEY SA, HARDIE DG, SCOTT J, BERI RK, CARLING Det al., 1995, THE AMP-ACTIVATED PROTEIN-KINASE GENE IS HIGHLY EXPRESSED IN RAT SKELETAL-MUSCLE - ALTERNATIVE SPLICING AND TISSUE DISTRIBUTION OF THE MESSENGER-RNA, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 228, Pages: 236-243, ISSN: 0014-2956

Journal article

BERI RK, MARLEY AE, SEE CG, SOPWITH WF, AGUAN K, CARLING D, SCOTT J, CAREY Fet al., 1994, MOLECULAR-CLONING, EXPRESSION AND CHROMOSOMAL LOCALIZATION OF HUMAN AMP-ACTIVATED, FEBS LETTERS, Vol: 356, Pages: 117-121, ISSN: 0014-5793

Journal article

Hardie DG, Carling D, Halford N, 1994, Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress., Semin Cell Biol, Vol: 5, Pages: 409-416, ISSN: 1043-4682

The AMP-activated protein kinase (AMPK) inhibits several biosynthetic pathways in mammals, and is activated in response to stresses which cause ATP depletion, e.g. heat shock. This system may therefore protect cells against environmental stress by switching off biosynthesis (i.e. growth) to conserve ATP. Recent biochemical and molecular genetic studies have shown that AMPK is closely related to the SNF1 gene product from Saccharomyces cerevisiae, and its homologues in higher plants. SNF1 is required for the response to starvation for glucose. Thus the novel function of providing protection against environmental stress may have evolved from a more ancient response to nutritional stress.

Journal article

SULLIVAN JE, BROCKLEHURST KJ, MARLEY AE, CAREY F, CARLING D, BERI RKet al., 1994, INHIBITION OF LIPOLYSIS AND LIPOGENESIS IN ISOLATED RAT ADIPOCYTES WITH AICAR, A CELL-PERMEABLE ACTIVATOR OF AMP-ACTIVATED PROTEIN-KINASE, FEBS LETTERS, Vol: 353, Pages: 33-36, ISSN: 0014-5793

Journal article

WOODS A, MUNDAY MR, SCOTT J, YANG XL, CARLSON M, CARLING Det al., 1994, YEAST SNF1 IS FUNCTIONALLY RELATED TO MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE AND REGULATES ACETYL-COA CARBOXYLASE IN-VIVO, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 19509-19515, ISSN: 0021-9258

Journal article

DAVIES SP, HAWLEY SA, WOODS A, CARLING D, HAYSTEAD TAJ, HARDIE DGet al., 1994, PURIFICATION OF THE AMP-ACTIVATED PROTEIN-KINASE ON ATP-GAMMA-SEPHAROSE AND ANALYSIS OF ITS SUBUNIT STRUCTURE, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 223, Pages: 351-357, ISSN: 0014-2956

Journal article

VERHOEVEN AJM, CARLING D, JANSEN H, 1994, HEPATIC LIPASE GENE IS TRANSCRIBED IN RAT ADRENALS INTO A TRUNCATED MESSENGER-RNA, JOURNAL OF LIPID RESEARCH, Vol: 35, Pages: 966-975, ISSN: 0022-2275

Journal article

SULLIVAN JE, CAREY F, CARLING D, BERI RKet al., 1994, CHARACTERIZATION OF 5'-AMP-ACTIVATED PROTEIN-KINASE IN HUMAN LIVER USING SPECIFIC PEPTIDE-SUBSTRATES AND THE EFFECTS OF 5'-AMP ANALOGS ON ENZYME-ACTIVITY, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 200, Pages: 1551-1556, ISSN: 0006-291X

Journal article

CARLING D, AGUAN K, WOODS A, VERHOEVEN AJM, BERI RK, BRENNAN CH, SIDEBOTTOM C, DAVISON MD, SCOTT Jet al., 1994, MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE IS HOMOLOGOUS TO YEAST AND PLANT PROTEIN-KINASES INVOLVED IN THE REGULATION OF CARBON METABOLISM, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 11442-11448, ISSN: 0021-9258

Journal article

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