Imperial College London

ProfessorDavidCarling

Faculty of MedicineInstitute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 3313 4313david.carling

 
 
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Location

 

3rd Fl CRBHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Frost:2014:10.1038/ncomms4611,
author = {Frost, G and Sleeth, ML and Sahuri-Arisoylu, M and Lizarbe, B and Cerdan, S and Brody, L and Anastasovska, J and Ghourab, S and Hankir, M and Zhang, S and Carling, D and Swann, JR and Gibson, G and Viardot, A and Morrison, D and Thomas, EL and Bell, JD},
doi = {10.1038/ncomms4611},
journal = {Nature Communications},
title = {The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism},
url = {http://dx.doi.org/10.1038/ncomms4611},
volume = {5},
year = {2014}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has been reported to decrease body weight, although the mechanism remains unclear. Here we use in vivo11C-acetate and PET-CT scanning to show that colonic acetate crosses the blood–brain barrier and is taken up by the brain. Intraperitoneal acetate results in appetite suppression and hypothalamic neuronal activation patterning. We also show that acetate administration is associated with activation of acetyl-CoA carboxylase and changes in the expression profiles of regulatory neuropeptides that favour appetite suppression. Furthermore, we demonstrate through 13C high-resolution magic-angle-spinning that 13C acetate from fermentation of 13C-labelled carbohydrate in the colon increases hypothalamic 13C acetate above baseline levels. Hypothalamic 13C acetate regionally increases the 13C labelling of the glutamate–glutamine and GABA neuroglial cycles, with hypothalamic 13C lactate reaching higher levels than the ‘remaining brain’. These observations suggest that acetate has a direct role in central appetite regulation.
AU - Frost,G
AU - Sleeth,ML
AU - Sahuri-Arisoylu,M
AU - Lizarbe,B
AU - Cerdan,S
AU - Brody,L
AU - Anastasovska,J
AU - Ghourab,S
AU - Hankir,M
AU - Zhang,S
AU - Carling,D
AU - Swann,JR
AU - Gibson,G
AU - Viardot,A
AU - Morrison,D
AU - Thomas,EL
AU - Bell,JD
DO - 10.1038/ncomms4611
PY - 2014///
SN - 2041-1723
TI - The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms4611
UR - http://hdl.handle.net/10044/1/40019
VL - 5
ER -