Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Professor of Biochemistry



+44 (0)20 3313 4313david.carling




3rd Fl CRBHammersmith HospitalHammersmith Campus






BibTex format

author = {Carling, D},
doi = {10.1016/},
journal = {Current Opinion in Cell Biology},
pages = {31--37},
title = {AMPK signalling in health and disease},
url = {},
volume = {45},
year = {2017}

RIS format (EndNote, RefMan)

AB - In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Activation of AMPK increases the rate of catabolic (ATP-generating) pathways and decreases the rate of anabolic (ATP-utilising) pathways. In addition to its role in maintaining intracellular energy balance, AMPK regulates whole body energy metabolism. Given its key role in controlling energy homeostasis, AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases, including type 2 diabetes and, more recently, cancer. Here I review the regulation of AMPK and its potential as a target for therapeutic intervention in human disease.
AU - Carling,D
DO - 10.1016/
EP - 37
PY - 2017///
SN - 1879-0410
SP - 31
TI - AMPK signalling in health and disease
T2 - Current Opinion in Cell Biology
UR -
UR -
UR -
VL - 45
ER -