Publications
215 results found
Bright NJ, Thornton C, Carling D, 2009, The regulation and function of mammalian AMPK-related kinases, ACTA PHYSIOLOGICA, Vol: 196, Pages: 15-26, ISSN: 1748-1708
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- Citations: 129
Martin MJ, Carling D, Marais R, 2009, Taking the Stress out of Melanoma, CANCER CELL, Vol: 15, Pages: 163-164, ISSN: 1535-6108
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- Citations: 10
Carling D, 2009, Branching out on AMPK Regulation, CELL METABOLISM, Vol: 9, Pages: 7-8, ISSN: 1550-4131
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- Citations: 5
Denison FC, Hiscock NJ, Carling D, et al., 2009, Characterisation of an alternative splice variant of LKB1, J. Biol. Chem., Vol: 284, Pages: 67-76
Sag D, Carling D, Stout RD, et al., 2008, Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 8633-8641, ISSN: 0022-1767
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- Citations: 561
Carling D, Sanders MJ, Woods A, 2008, The regulation of AMP-activated protein kinase by upstream kinases, INTERNATIONAL JOURNAL OF OBESITY, Vol: 32, Pages: S55-S59, ISSN: 0307-0565
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- Citations: 227
Thornton C, Sardini A, Carling D, 2008, Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 17116-17122
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- Citations: 28
Lopez M, Lage R, Saha AK, et al., 2008, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin, CELL METABOLISM, Vol: 7, Pages: 389-399, ISSN: 1550-4131
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- Citations: 374
Bright NJ, Carling D, Thornton C, 2008, Investigating the regulation of brain specific kinases 1 and 2 by phosphorylation, J. Biol. Chem., Vol: 283, Pages: 14946-14954
Li P, Carling D, Hotamisligil GS, et al., 2007, Discussion, Pages: 81-85, ISSN: 1528-2511
Brooks NL, Trent CM, Raetzsch CF, et al., 2007, Low utilization of circulating glucose after food withdrawal in Snell dwarf mice, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 35069-35077
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- Citations: 38
Sanders MJ, Ali ZS, Hegarty BD, et al., 2007, Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 32539-32548
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- Citations: 266
Oliveira SM, Zhang Y-H, Davies J, et al., 2007, AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility in murine ventricular myocytes, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 304-305, ISSN: 0009-7322
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- Citations: 1
Dranchak PK, Leiper FC, Valberg SJ, et al., 2007, Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses, AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol: 68, Pages: 1079-1084, ISSN: 0002-9645
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- Citations: 9
Stocker C, Wargent E, O'Dowd J, et al., 2007, Patterns of postnatal growth impact on the early life programming of energy balance, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S113-S114, ISSN: 0378-3782
Xiao B, Heath R, Saiu P, et al., 2007, Structural basis for AMP binding to mammalian AMP-activated protein kinase, NATURE, Vol: 449, Pages: 496-U14, ISSN: 0028-0836
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- Citations: 438
Claret M, Smith MA, Batterham RL, et al., 2007, AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 2325-2336, ISSN: 0021-9738
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- Citations: 405
Viana R, Towler MC, Pan DA, et al., 2007, A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase γ subunits is required for the interaction with the β subunits, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 16117-16125
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- Citations: 24
Aguilar V, Alliouachene S, Sotiropoulos A, et al., 2007, S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase, CELL METABOLISM, Vol: 5, Pages: 476-487, ISSN: 1550-4131
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- Citations: 144
Cheng KKY, Lam KSL, Wang Y, et al., 2007, Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells, DIABETES, Vol: 56, Pages: 1387-1394, ISSN: 0012-1797
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- Citations: 266
Sanders MJ, Grondin PO, Hegarty BD, et al., 2007, Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade, BIOCHEMICAL JOURNAL, Vol: 403, Pages: 139-148, ISSN: 0264-6021
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- Citations: 510
Carling D, 2007, AMP-activated protein kinase and the regulation of energy metabolism, Experimental Biology 2007 Annual Meeting, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: A206-A206, ISSN: 0892-6638
Kuramoto N, Wilkins ME, Fairfax BP, et al., 2007, Phospho-dependent functional modulation of GABA<sub>B</sub> receptors by the metabolic sensor AMP-dependent protein kinase, NEURON, Vol: 53, Pages: 233-247, ISSN: 0896-6273
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- Citations: 154
Oliveira SM, Davies J, Carling D, et al., 2007, Cardiac troponin I is a potential novel substrate for AMP-activated protein kinase, 51st Annual Meeting of the Biophysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 180A-180A, ISSN: 0006-3495
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- Citations: 1
Carling D, 2007, The role of the AMP-activated protein kinase in the regulation of energy homeostasis., Novartis Found Symp, Vol: 286, Pages: 72-81, ISSN: 1528-2511
AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that plays a major role in maintaining energy homeostasis. Within individual cells, AMPK is activated by a rise in the AMP:ATP ratio that occurs following a fall in ATP levels. AMPK is also regulated by the adipokines, adiponectin and leptin, hormones that are secreted from adipocytes. Activation of AMPK requires phosphorylation of threonine 172 within the catalytic subunit by either LKB1 or calcium/calmodulin dependent protein kinase kinase beta (CaMKKbeta). AMPK regulates a wide range of metabolic pathways, including fatty acid oxidation, fatty acid synthesis, glycolysis and gluconeogenesis. In peripheral tissues, activation of AMPK leads to responses that are beneficial in counteracting the deleterious effects that arise in the metabolic syndrome. Recent studies have demonstrated that modulation of AMPK activity in the hypothalamus plays a role in feeding. A decrease in hypothalamic AMPK activity is associated with decreased feeding, whereas activation of AMPK leads to increased food intake. Furthermore, signalling pathways in the hypothalamus lead to changes in AMPK activity in peripheral tissues, such as skeletal muscle, via the sympathetic nervous system (SNS). AMPK, therefore, provides a mechanism for monitoring changes in energy metabolism within individual cells and at the level of the whole body.
Steinberg GR, Michell BJ, van Denderen BJW, et al., 2006, Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling, CELL METABOLISM, Vol: 4, Pages: 465-474, ISSN: 1550-4131
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- Citations: 336
Li J, Coven DL, Miller EJ, et al., 2006, Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 291, Pages: H1927-H1934, ISSN: 0363-6135
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- Citations: 55
Stahmann N, Woods A, Carling D, et al., 2006, Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca<SUP>2+</SUP>/calmodulin-dependent protein kinase kinase β, MOLECULAR AND CELLULAR BIOLOGY, Vol: 26, Pages: 5933-5945, ISSN: 0270-7306
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- Citations: 181
Davies JK, Wells DJ, Liu K, et al., 2006, Characterization of the role of γ2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 290, Pages: H1942-H1951, ISSN: 0363-6135
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- Citations: 67
Watt MJ, Dzamko N, Thomas WG, et al., 2006, CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK, NATURE MEDICINE, Vol: 12, Pages: 541-548, ISSN: 1078-8956
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- Citations: 240
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