Imperial College London
Alternate

ProfessorDavidCarling

Faculty of Medicine, Institute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)7590 250 559david.carling

 
 
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Location

 

2.14DLMS BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

215 results found

Carling D, Woods A, Thornton C, Cheung PCF, Smith FC, Ponticos M, Stein SCet al., 1997, Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: 1224-1228, ISSN: 0300-5127

Journal article

Cheung PCF, Carling D, 1997, Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues, 662nd Meeting of the Biochemical-Society, Publisher: PORTLAND PRESS, Pages: S668-S668, ISSN: 0300-5127

Conference paper

Thornton C, Snowden MA, Carling D, 1997, Identification of a novel AMPKβ subunit that is highly expressed in skeletal muscle, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: S667-S667, ISSN: 0300-5127

Journal article

Hardie DG, Carling D, 1997, The AMP-activated protein kinase - Fuel gauge of the mammalian cell?, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 246, Pages: 259-273, ISSN: 0014-2956

Journal article

Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TWet al., 1997, Identification of Raf-1 Ser(621) kinase activity from NIH 3T3 cells as AMP-activated protein kinase, FEBS LETTERS, Vol: 403, Pages: 254-258, ISSN: 0014-5793

Journal article

Marley AE, Sullivan JE, Carling D, Abbott WM, Smith GJ, Taylor IWF, Carey F, Beri RKet al., 1996, Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha, BIOCHEMICAL JOURNAL, Vol: 320, Pages: 801-806, ISSN: 0264-6021

Journal article

Woods A, Salt I, Scott J, Hardie DG, Carling Det al., 1996, The alpha 1 and alpha 2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro, FEBS LETTERS, Vol: 397, Pages: 347-351, ISSN: 0014-5793

Journal article

Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DGet al., 1996, Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 27879-27887, ISSN: 0021-9258

Journal article

Woods A, Cheung PCF, Smith FC, Davison MD, Scott J, Beri RK, Carling Det al., 1996, Characterization of AMP-activated protein kinase beta and gamma subunits - Assembly of the heterotrimeric complex in vitro, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 10282-10290, ISSN: 0021-9258

Journal article

HAWLEY SA, SELBERT MA, GOLDSTEIN EG, EDELMAN AM, CARLING D, HARDIE DGet al., 1995, 5'-AMP ACTIVATES THE AMP-ACTIVATED PROTEIN-KINASE CASCADE AND CA2+/CALMODULIN ACTIVATES THE CALMODULIN-DEPENDENT PROTEIN-KINASE-I CASCADE, VIA 3 INDEPENDENT MECHANISMS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 27186-27191, ISSN: 0021-9258

Journal article

VERHOEVEN AJM, WOODS A, BRENNAN CH, HAWLEY SA, HARDIE DG, SCOTT J, BERI RK, CARLING Det al., 1995, THE AMP-ACTIVATED PROTEIN-KINASE GENE IS HIGHLY EXPRESSED IN RAT SKELETAL-MUSCLE - ALTERNATIVE SPLICING AND TISSUE DISTRIBUTION OF THE MESSENGER-RNA, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 228, Pages: 236-243, ISSN: 0014-2956

Journal article

BERI RK, MARLEY AE, SEE CG, SOPWITH WF, AGUAN K, CARLING D, SCOTT J, CAREY Fet al., 1994, MOLECULAR-CLONING, EXPRESSION AND CHROMOSOMAL LOCALIZATION OF HUMAN AMP-ACTIVATED, FEBS LETTERS, Vol: 356, Pages: 117-121, ISSN: 0014-5793

Journal article

Hardie DG, Carling D, Halford N, 1994, Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress., Semin Cell Biol, Vol: 5, Pages: 409-416, ISSN: 1043-4682

The AMP-activated protein kinase (AMPK) inhibits several biosynthetic pathways in mammals, and is activated in response to stresses which cause ATP depletion, e.g. heat shock. This system may therefore protect cells against environmental stress by switching off biosynthesis (i.e. growth) to conserve ATP. Recent biochemical and molecular genetic studies have shown that AMPK is closely related to the SNF1 gene product from Saccharomyces cerevisiae, and its homologues in higher plants. SNF1 is required for the response to starvation for glucose. Thus the novel function of providing protection against environmental stress may have evolved from a more ancient response to nutritional stress.

Journal article

SULLIVAN JE, BROCKLEHURST KJ, MARLEY AE, CAREY F, CARLING D, BERI RKet al., 1994, INHIBITION OF LIPOLYSIS AND LIPOGENESIS IN ISOLATED RAT ADIPOCYTES WITH AICAR, A CELL-PERMEABLE ACTIVATOR OF AMP-ACTIVATED PROTEIN-KINASE, FEBS LETTERS, Vol: 353, Pages: 33-36, ISSN: 0014-5793

Journal article

WOODS A, MUNDAY MR, SCOTT J, YANG XL, CARLSON M, CARLING Det al., 1994, YEAST SNF1 IS FUNCTIONALLY RELATED TO MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE AND REGULATES ACETYL-COA CARBOXYLASE IN-VIVO, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 19509-19515, ISSN: 0021-9258

Journal article

DAVIES SP, HAWLEY SA, WOODS A, CARLING D, HAYSTEAD TAJ, HARDIE DGet al., 1994, PURIFICATION OF THE AMP-ACTIVATED PROTEIN-KINASE ON ATP-GAMMA-SEPHAROSE AND ANALYSIS OF ITS SUBUNIT STRUCTURE, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 223, Pages: 351-357, ISSN: 0014-2956

Journal article

VERHOEVEN AJM, CARLING D, JANSEN H, 1994, HEPATIC LIPASE GENE IS TRANSCRIBED IN RAT ADRENALS INTO A TRUNCATED MESSENGER-RNA, JOURNAL OF LIPID RESEARCH, Vol: 35, Pages: 966-975, ISSN: 0022-2275

Journal article

SULLIVAN JE, CAREY F, CARLING D, BERI RKet al., 1994, CHARACTERIZATION OF 5'-AMP-ACTIVATED PROTEIN-KINASE IN HUMAN LIVER USING SPECIFIC PEPTIDE-SUBSTRATES AND THE EFFECTS OF 5'-AMP ANALOGS ON ENZYME-ACTIVITY, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 200, Pages: 1551-1556, ISSN: 0006-291X

Journal article

CARLING D, AGUAN K, WOODS A, VERHOEVEN AJM, BERI RK, BRENNAN CH, SIDEBOTTOM C, DAVISON MD, SCOTT Jet al., 1994, MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE IS HOMOLOGOUS TO YEAST AND PLANT PROTEIN-KINASES INVOLVED IN THE REGULATION OF CARBON METABOLISM, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 11442-11448, ISSN: 0021-9258

Journal article

DAVIES SP, CARLING D, MUNDAY MR, HARDIE DGet al., 1992, DIURNAL RHYTHM OF PHOSPHORYLATION OF RAT-LIVER ACETYL COA CARBOXYLASE BY THE AMP-ACTIVATED PROTEIN-KINASE, DEMONSTRATED USING FREEZE-CLAMPING - EFFECTS OF HIGH-FAT DIETS, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 203, Pages: 615-623, ISSN: 0014-2956

Journal article

Carling D, Clarke PR, Grahame Hardie D, 1991, [29] Adenosine monophosphate-activated protein kinase: Hydroxymethylglutaryl-CoA reductase kinase, Methods in Enzymology, Publisher: Elsevier, Pages: 362-371

Book chapter

CARLING D, CLARKE PR, HARDIE DG, 1991, ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN-KINASE - HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE, METHODS IN ENZYMOLOGY, Vol: 200, Pages: 362-371, ISSN: 0076-6879

Journal article

DAVIES SP, CARLING D, HARDIE DG, 1989, TISSUE DISTRIBUTION OF THE AMP-ACTIVATED PROTEIN-KINASE, AND LACK OF ACTIVATION BY CYCLIC-AMP-DEPENDENT PROTEIN-KINASE, STUDIED USING A SPECIFIC AND SENSITIVE PEPTIDE ASSAY, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 186, Pages: 123-128, ISSN: 0014-2956

Journal article

CARLING D, CLARKE PR, ZAMMIT VA, HARDIE DGet al., 1989, PURIFICATION AND CHARACTERIZATION OF THE AMP-ACTIVATED PROTEIN-KINASE - COPURIFICATION OF ACETYL-COA CARBOXYLASE KINASE AND 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE KINASE-ACTIVITIES, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 186, Pages: 129-136, ISSN: 0014-2956

Journal article

CARLING D, HARDIE DG, 1989, THE SUBSTRATE AND SEQUENCE SPECIFICITY OF THE AMP-ACTIVATED PROTEIN-KINASE - PHOSPHORYLATION OF GLYCOGEN-SYNTHASE AND PHOSPHORYLASE-KINASE, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1012, Pages: 81-86, ISSN: 0006-3002

Journal article

GARTON AJ, CAMPBELL DG, CARLING D, HARDIE DG, COLBRAN RJ, YEAMAN SJet al., 1989, PHOSPHORYLATION OF BOVINE HORMONE-SENSITIVE LIPASE BY THE AMP-ACTIVATED PROTEIN-KINASE - A POSSIBLE ANTILIPOLYTIC MECHANISM, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 179, Pages: 249-254, ISSN: 0014-2956

Journal article

HAYSTEAD TAJ, SIM ATR, CARLING D, HONNOR RC, TSUKITANI Y, COHEN P, HARDIE DGet al., 1989, EFFECTS OF THE TUMOR PROMOTER OKADAIC ACID ON INTRACELLULAR PROTEIN-PHOSPHORYLATION AND METABOLISM, NATURE, Vol: 337, Pages: 78-81, ISSN: 0028-0836

Journal article

HARDIE DG, CARLING D, SIM ATR, 1989, THE AMP-ACTIVATED PROTEIN-KINASE - A MULTISUBSTRATE REGULATOR OF LIPID-METABOLISM, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 14, Pages: 20-23, ISSN: 0968-0004

Journal article

MUNDAY MR, CARLING D, HARDIE DG, 1988, NEGATIVE INTERACTIONS BETWEEN PHOSPHORYLATION OF ACETYL-COA CARBOXYLASE BY THE CYCLIC AMP-DEPENDENT AND AMP-ACTIVATED PROTEIN-KINASES, FEBS LETTERS, Vol: 235, Pages: 144-148, ISSN: 0014-5793

Journal article

MUNDAY MR, CAMPBELL DG, CARLING D, HARDIE DGet al., 1988, IDENTIFICATION BY AMINO-ACID SEQUENCING OF 3 MAJOR REGULATORY PHOSPHORYLATION SITES ON RAT ACETYL-COA CARBOXYLASE, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 175, Pages: 331-338, ISSN: 0014-2956

Journal article

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