Imperial College London
Alternate

ProfessorDavidCarling

Faculty of Medicine, Institute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)7590 250 559david.carling

 
 
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Location

 

2.14DLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lima:2021:10.1038/s42255-021-00422-7,
author = {Lima, A and Lubatti, G and Burgstaller, J and Hu, D and Green, AP and Di, Gregorio A and Zawadzki, T and Pernaute, B and Mahammadov, E and Perez-Montero, S and Dore, M and Sanchez, JM and Bowling, S and Sancho, M and Kolbe, T and Karimi, MM and Carling, D and Jones, N and Srinivas, S and Sciadldone, A and Rodriguez, T},
doi = {10.1038/s42255-021-00422-7},
journal = {Nature Metabolism},
pages = {1091--1108},
title = {Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development},
url = {http://dx.doi.org/10.1038/s42255-021-00422-7},
volume = {3},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a wide range of settings from development to the adult. However, the nature of the cells normally eliminated by cell competition and what triggers their elimination remains poorly understood. In mice, 35% of epiblast cells are eliminated prior to gastrulation. Here we show that cells with mitochondrial defects are eliminated by cell competition during early mouse development. Using single cell transcriptional profiling of eliminated mouse epiblast cells we identify hallmarks of cell competition and mitochondrial defects. We go on to demonstrate that mitochondrial defects are common to a range of different loser cell types and that manipulating mitochondrial function triggers cell competition. In the mouse embryo, cell competition eliminates cells with sequence changes in mt-Rnr1 and mt-Rnr2, and that even non-pathological changes in mitochondrial DNA sequence can induce cell competition. Our results suggest that cell competition is a purifying selection that optimises mitochondrial performance prior to gastrulation.
AU  - Lima,A
AU  - Lubatti,G
AU  - Burgstaller,J
AU  - Hu,D
AU  - Green,AP
AU  - Di,Gregorio A
AU  - Zawadzki,T
AU  - Pernaute,B
AU  - Mahammadov,E
AU  - Perez-Montero,S
AU  - Dore,M
AU  - Sanchez,JM
AU  - Bowling,S
AU  - Sancho,M
AU  - Kolbe,T
AU  - Karimi,MM
AU  - Carling,D
AU  - Jones,N
AU  - Srinivas,S
AU  - Sciadldone,A
AU  - Rodriguez,T
DO  - 10.1038/s42255-021-00422-7
EP  - 1108
PY  - 2021///
SN  - 2522-5812
SP  - 1091
TI  - Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development
T2  - Nature Metabolism
UR  - http://dx.doi.org/10.1038/s42255-021-00422-7
UR  - https://www.nature.com/articles/s42255-021-00422-7
UR  - http://hdl.handle.net/10044/1/90241
VL  - 3
ER  -
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