Imperial College London
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Dr. David James PINATO

Faculty of Medicine, Department of Surgery & Cancer

Clinical Reader in Medical Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2799david.pinato Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pinato:2018:10.1186/s12885-018-4120-4,
author = {Pinato, DJ and Pai, M and Reccia, I and Patel, M and Giakoustidis, A and Karamanakos, G and Rushd, A and Jamshaid, S and Oldani, A and Grossi, G and Pirisi, M and Tait, P and Sharma, R},
doi = {10.1186/s12885-018-4120-4},
journal = {BMC Cancer},
title = {Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma.},
url = {http://dx.doi.org/10.1186/s12885-018-4120-4},
volume = {18},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Survival advantage following trans-arterial chemoembolization (TACE) is variable in patients with hepatocellular carcinoma (HCC). We combined pre-TACE radiologic features to derive a novel prognostic signature in HCC. METHODS: A multi-institutional dataset of 98 patients was generated from two retrospective cohorts from United Kingdom (65%) and Italy (36%). The prognostic impact of a number baseline imaging parameters was assessed and factors significant on univariate analysis were combined to create a novel radiologic signature on multivariable analyses predictive of overall survival (OS) following TACE. RESULTS: Median OS was 15.4 months. Tumour size > 7 cm (p < 0.001), intra-tumour necrosis (ITN) (p = 0.02) and arterial ectatic neovascularisation (AEN) (p = 0.03) emerged as individual prognostic factors together with radiologic response (p < 0.001) and elevated alpha-fetoprotein (AFP) (p = 0.01). Combination of tumour size > 7 cm, ITN and AEN identified patients with poor prognosis (p < 0.001). CONCLUSIONS: We identified a coherent signature based on commonly available imaging biomarkers likely to be reflective of differential patterns of relative hypoxia and neovascularisation. Large tumours displaying AEN and ITN are characterised by a shorter survival after TACE.
AU  - Pinato,DJ
AU  - Pai,M
AU  - Reccia,I
AU  - Patel,M
AU  - Giakoustidis,A
AU  - Karamanakos,G
AU  - Rushd,A
AU  - Jamshaid,S
AU  - Oldani,A
AU  - Grossi,G
AU  - Pirisi,M
AU  - Tait,P
AU  - Sharma,R
DO  - 10.1186/s12885-018-4120-4
PY  - 2018///
SN  - 1471-2407
TI  - Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma.
T2  - BMC Cancer
UR  - http://dx.doi.org/10.1186/s12885-018-4120-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29463228
UR  - http://hdl.handle.net/10044/1/57453
VL  - 18
ER  -
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