Imperial College London
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ProfessorDavidSharp

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology
 
 
 
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Contact

 

+44 (0)20 7594 7991david.sharp Website

 
 
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Location

 

UREN.927Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hughes:2020:10.1016/j.mri.2020.02.007,
author = {Hughes, SW and Hellyer, PJ and Sharp, DJ and Newbould, RD and Patel, MC and Strutton, PH},
doi = {10.1016/j.mri.2020.02.007},
journal = {Magnetic Resonance Imaging},
pages = {65--70},
title = {Diffusion tensor imaging of lumbar spinal nerves reveals changes in microstructural integrity following decompression surgery associated with improvements in clinical symptoms: A case report},
url = {http://dx.doi.org/10.1016/j.mri.2020.02.007},
volume = {69},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The outcomes from spinal nerve decompression surgery are highly variable with a sizable proportion of elderly foraminal stenosis patients not regaining good pain relief. A better understanding of nerve root compression before and following decompression surgery and whether these changes are mirrored by improvements in symptoms may help to improve clinical decision-making processes. This case study used a combination of diffusion tensor imaging (DTI), clinical questionnaires and motor neurophysiology assessments before and up to 3 months following spinal decompression surgery. In this case report, a 70-year-old women with compression of the left L5 spinal nerve root in the L5-S1 exit foramina was recruited to the study. At 3 months following surgery, DTI revealed marked improvements in left L5 microstructural integrity to a similar level to that seen in the intact right L5 nerve root. This was accompanied by a gradual improvement in pain-related symptoms, mood and disability score by 3 months. Using this novel multimodal approach, it may be possible to track concurrent improvements in pain-related symptoms, function and microstructural integrity of compressed nerves in elderly foraminal stenosis patients undergoing decompression surgery.
AU  - Hughes,SW
AU  - Hellyer,PJ
AU  - Sharp,DJ
AU  - Newbould,RD
AU  - Patel,MC
AU  - Strutton,PH
DO  - 10.1016/j.mri.2020.02.007
EP  - 70
PY  - 2020///
SN  - 0730-725X
SP  - 65
TI  - Diffusion tensor imaging of lumbar spinal nerves reveals changes in microstructural integrity following decompression surgery associated with improvements in clinical symptoms: A case report
T2  - Magnetic Resonance Imaging
UR  - http://dx.doi.org/10.1016/j.mri.2020.02.007
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32084517
UR  - http://hdl.handle.net/10044/1/77952
VL  - 69
ER  -
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