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@unpublished{Graham:2020:10.1101/2020.05.19.20105460,
author = {Graham, NSN and Junghans, C and Downes, R and Sendall, C and Lai, H and McKirdy, A and Elliott, P and Howard, R and Wingfield, D and Priestman, M and Ciechonska, M and Cameron, L and Storch, M and Crone, MA and Freemont, PS and Randell, P and McLaren, R and Lang, N and Ladhani, S and Sanderson, F and Sharp, DJ},
doi = {10.1101/2020.05.19.20105460},
title = {SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes},
url = {http://dx.doi.org/10.1101/2020.05.19.20105460},
year = {2020}
}

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TY  - UNPB
AB  - <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>An outbreak investigation.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>4 nursing homes affected by COVID-19 outbreaks in central London.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>394 residents and 70 staff in nursing homes.</jats:p></jats:sec><jats:sec><jats:title>Interventions</jats:title><jats:p>Two point-prevalence surveys one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing.</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>All-cause mortality, and mortality attributed to COVID-19 on death certificates. Prevalence of SARS-CoV-2 infection and symptoms in residents and staff.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, 26% (95% confidence interval 22 to 31) of residents died over the two-month period. All-cause mortality increased by 203% (95% CI 70 to 336). Systematic testing identified 40% (95% CI 35 to 46) of residents, of whom 43% (95% CI 34 to 52) were asymptomatic and 18% (95% CI 11 to 24) had atypical symptoms, as well as 4% (95% CI -1 to 9) of asymptomatic staff who tested positive for SARS-CoV-2.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The SARS-CoV-2 outbreak was associated with a ver
AU  - Graham,NSN
AU  - Junghans,C
AU  - Downes,R
AU  - Sendall,C
AU  - Lai,H
AU  - McKirdy,A
AU  - Elliott,P
AU  - Howard,R
AU  - Wingfield,D
AU  - Priestman,M
AU  - Ciechonska,M
AU  - Cameron,L
AU  - Storch,M
AU  - Crone,MA
AU  - Freemont,PS
AU  - Randell,P
AU  - McLaren,R
AU  - Lang,N
AU  - Ladhani,S
AU  - Sanderson,F
AU  - Sharp,DJ
DO  - 10.1101/2020.05.19.20105460
PY  - 2020///
TI  - SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes
UR  - http://dx.doi.org/10.1101/2020.05.19.20105460
ER  -

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