Imperial College London
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ProfessorDavidSharp

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology
 
 
 
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Contact

 

+44 (0)20 7594 7991david.sharp Website

 
 
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Location

 

UREN.927Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cole:2018:brain/awx354,
author = {Cole, JH and Jolly, A and De, Simoni S and Bourke, N and patel, M and Scott, G and Sharp, D},
doi = {brain/awx354},
journal = {Brain},
pages = {822--836},
title = {Spatial patterns of progressive brain volume loss after moderate-severe traumatic brain injury},
url = {http://dx.doi.org/10.1093/brain/awx354},
volume = {141},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Traumatic brain injury leads to significant loss of brain volume, which continues into the chronic stage. This can be sensitively measured using volumetric analysis of magnetic resonance imaging. Here we: (i) investigated longitudinal patterns of brain atrophy; (ii) tested whether atrophy is greatest in sulcal cortical regions, and (iii) showed how atrophy could be used to power intervention trials aimed at slowing neurodegeneration. In 61 moderate/severe traumatic brain injury patients (mean age = 41.55 years ± 12.77) and 32 healthy controls (mean age = 34.22 years ± 10.29), cross-sectional and longitudinal (one-year follow-up) brain structure was assessed using voxel-based morphometry on T1-weighted scans. Longitudinal brain volume changes were characterised using a novel neuroimaging analysis pipeline that generates a Jacobian determinant metric, reflecting spatial warping between baseline and follow-up scans. Jacobian determinant values were summarised regionally and compared with clinical and neuropsychological measures. Traumatic brain injury patients showed lower grey and white matter volume in multiple brain regions compared to controls at baseline. Atrophy over one year was pronounced following traumatic brain injury. Traumatic brain injury patients lost a mean (± standard deviation) of 1.55% ± 2.19 of grey matter volume per year, 1.49% ± 2.20 of white matter volume or 1.51% ± 1.60 of whole brain volume. Healthy controls lost 0.55% ± 1.13 of grey matter volume and gained 0.26% ± 1.11 of white matter volume; equating to a 0.22% ± 0.83 reduction in whole brain volume. Atrophy was greatest in white matter, where the majority (84%) of regions were affected. This effect was independent of and substantially greater than that of ageing. Increased atrophy was also seen in cortical sulci compared to gyri. There was no relationship between atrophy and time since injury or age at baseline. Atrophy rates we
AU  - Cole,JH
AU  - Jolly,A
AU  - De,Simoni S
AU  - Bourke,N
AU  - patel,M
AU  - Scott,G
AU  - Sharp,D
DO  - brain/awx354
EP  - 836
PY  - 2018///
SN  - 1460-2156
SP  - 822
TI  - Spatial patterns of progressive brain volume loss after moderate-severe traumatic brain injury
T2  - Brain
UR  - http://dx.doi.org/10.1093/brain/awx354
UR  - http://hdl.handle.net/10044/1/55263
VL  - 141
ER  -
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