Dr Declan O'Regan is an MRC Clinical Scientist and Consultant Radiologist who heads the Robert Steiner MRI suite (Mansfield Centre for Innovation) at the MRC London Institute of Medical Sciences. He is lead clinician for imaging research at Imperial College Healthcare NHS Trust. He is committed to science engagement and is a past Roentgen (UK) and Rowan-Williams (Australasia) travelling professor.
His research is focussed on developing artificial intelligence to understand the genetic and physiological mechanisms that underpin cardiovascular disease using cardiac imaging. His team recently developed the 4Dsurvival algorithm for predicting outcomes in heart disease from cardiac motion analysis (Nature Machine Intelligence). His projects include:
- Developing advanced computer vision algorithms in cardiac MRI.
- Predicting time-to-events from cardiac motion analysis.
- Automated discovery of cardiac genotype-phenotype associations in health and disease.
- Designing artificial reasoning systems to classify heart disease.
- Accelerating drug discovery using machine learning in UK Biobank.
- Discovering new quantitative imaging risk factors in heart disease.
His interdisciplinary collaborators include Prof Stuart Cook, Prof Daniel Rueckert, and Prof Ewan Birney. This research is funded by NIHR, BHF and MRC.
et al., Genetic and functional insights into the fractal structure of the heart, Nature, ISSN:0028-0836
et al., 2020, Artificial intelligence and the cardiologist: what you need to know for 2020., Heart, Vol:106, ISSN:1355-6037, Pages:399-400
et al., 2019, Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: Three dimensional analysis of cardiac magnetic resonance imaging, Ehj Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging, Vol:20, ISSN:2047-2412, Pages:668-676
et al., 2019, Deep learning cardiac motion analysis for human survival prediction, Nature Machine Intelligence, Vol:1, ISSN:2522-5839, Pages:95-104
et al., 2018, Fractal analysis of right ventricular trabeculae in pulmonary hypertension, Radiology, Vol:288, ISSN:0033-8419, Pages:386-395
et al., 2017, Three-dimensional Cardiovascular Imaging-Genetics: A Mass Univariate Framework, Bioinformatics, ISSN:1367-4803
et al., 2016, Titin truncating variants affect heart function in disease cohorts and the general population, Nature Genetics, Vol:49, ISSN:1546-1718, Pages:46-53