Imperial College London
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ProfessorEdwinaBrown

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3311 7590e.a.brown

 
 
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Location

 

Renal OfficesHammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Iyasere:2019:ckj/sfy059,
author = {Iyasere, O and Brown, EA and Johansson, L and Davenport, A and Farrington, K and Maxwell, AP and Collinson, H and Fan, S and Habib, A-M and Stoves, J and Woodrow, G},
doi = {ckj/sfy059},
journal = {Clinical Kidney Journal},
pages = {262--268},
title = {Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis},
url = {http://dx.doi.org/10.1093/ckj/sfy059},
volume = {12},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThere is little information about quality of life (QoL) for patients with end-stage kidney disease (ESKD) choosing conservative kidney management (CKM). The Frail and Elderly Patients on Dialysis (FEPOD) study demonstrated that frailty was associated with poorer QoL outcomes with little difference between dialysis modalities [assisted peritoneal dialysis (aPD) or haemodialysis (HD)]. We therefore extended the FEPOD study to include CKM patients with estimated glomerular filtration rate ≤10 mL/min/1.73 m2 (i.e. individuals with ESKD otherwise likely to be managed with dialysis).MethodsCKM patients were propensity matched to HD and aPD patients by age, gender, ethnicity, diabetes status and index of deprivation. QoL outcomes measured were Short Form-12 (SF12), Hospital Anxiety and Depression Scale depression score, symptom score, Illness Intrusiveness Rating Scale (IIRS) and Renal Treatment Satisfaction Questionnaire. Frailty was assessed using the Clinical Frailty Scale. Generalized linear modelling was used to assess the impact of treatment modality on QoL outcomes, adjusting for baseline characteristics.ResultsIn total, 84 (28 CKM, 28 HD and 28 PD) patients were included. Median age for the cohort was 82 (79–88) years. Compared with CKM, aPD was associated with higher SF12 physical component score (PCS) [Exp B (95% confidence interval) = 1.20 (1.00–1.45), P < 0.05] and lower symptom score [Exp B = 0.62 (0.43–0.90), P = 0.01]; depression score was lower in HD compared with CKM [Exp B = 0.70 (0.52–0.92), P = 0.01]. Worsening frailty was associated with higher depression scores [Exp B = 2.59 (1.45–4.62), P < 0.01], IIRS [Exp B = 1.20 (1.12–1.28), P < 0.01] and lower SF12 PCS [Exp B = 0.87 (0.83–0.93), P < 0.01].ConclusionTr
AU  - Iyasere,O
AU  - Brown,EA
AU  - Johansson,L
AU  - Davenport,A
AU  - Farrington,K
AU  - Maxwell,AP
AU  - Collinson,H
AU  - Fan,S
AU  - Habib,A-M
AU  - Stoves,J
AU  - Woodrow,G
DO  - ckj/sfy059
EP  - 268
PY  - 2019///
SN  - 2048-8505
SP  - 262
TI  - Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis
T2  - Clinical Kidney Journal
UR  - http://dx.doi.org/10.1093/ckj/sfy059
UR  - http://hdl.handle.net/10044/1/70055
VL  - 12
ER  -
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