Imperial College London
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ProfessorEdwinaBrown

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3311 7590e.a.brown

 
 
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Location

 

Renal OfficesHammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brown:2021:10.1053/j.ajkd.2021.02.327,
author = {Brown, E and Zhao, J and Perl, J and McCullough, K and Fuller, DS and Figueiredo, AE and Bieber, B and Finkelstein, FO and Shen, J and Kanjanabuch, T and Kawanishi, H and Pisoni, RL and Perl, J and PDOPPS, Patient Support Working Group},
doi = {10.1053/j.ajkd.2021.02.327},
journal = {American Journal of Kidney Diseases},
pages = {489--500.el},
title = {Burden of kidney disease, health-related quality of life, and employment among patients receiving peritoneal dialysis and in-center hemodialysis: findings from the DOPPS Program},
url = {http://dx.doi.org/10.1053/j.ajkd.2021.02.327},
volume = {78},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale & Objective:Individuals faced with decisions regarding kidney replacement therapy options need information on how dialysis treatments might affect daily activities and quality of life, and what factors might influence the evolution over time of the impact of dialysis on daily activities and quality of life.Study Design:Observational cohort study.Setting & Participants7,771 hemodialysis (HD) and peritoneal dialysis (PD) participants from 6 countries participating in the Peritoneal and Dialysis Outcomes and Practice Patterns Studies (PDOPPS/DOPPS).Predictors:Patient-reported functional status (based on daily living activities), country, demographic and clinical characteristics, and comorbidities.Outcome:Employment status and patient-reported outcomes (PROs) including Kidney Disease Quality of Life (KDQOL) instrument physical and mental component summary scores (PCS, MCS), kidney disease burden score, and depression symptoms (Center for Epidemiologic Studies Depression Scale [CES-D] score > 10).Analytical Approach:Linear regression (PCS, MCS, kidney disease burden score), logistic regression (depression symptoms), adjusted for predictors plus 12 additional comorbidities.Results:In both dialysis modalities, patients in Japan had the highest PCS and employment (55% for HD and 68% for PD), whereas those in the United States had the highest MCS score, lowest kidney disease burden, and lowest employment (20% in HD and 42% in PD). After covariate adjustment, the association of age, sex, dialysis vintage, diabetes, and functional status with PROs was similar in both modalities, with women having lower PCS and kidney disease burden scores. Lower functional status (score <11) was strongly associated with lower PCS and MCS scores, a much greater burden of kidney disease, and greater likelihood of depression symptoms (CES-D, >10). The median change in KDQOL-based PROs was negligible over 1 year in participants who completed at least 2 annual questionnai
AU  - Brown,E
AU  - Zhao,J
AU  - Perl,J
AU  - McCullough,K
AU  - Fuller,DS
AU  - Figueiredo,AE
AU  - Bieber,B
AU  - Finkelstein,FO
AU  - Shen,J
AU  - Kanjanabuch,T
AU  - Kawanishi,H
AU  - Pisoni,RL
AU  - Perl,J
AU  - PDOPPS,Patient Support Working Group
DO  - 10.1053/j.ajkd.2021.02.327
EP  - 500
PY  - 2021///
SN  - 0272-6386
SP  - 489
TI  - Burden of kidney disease, health-related quality of life, and employment among patients receiving peritoneal dialysis and in-center hemodialysis: findings from the DOPPS Program
T2  - American Journal of Kidney Diseases
UR  - http://dx.doi.org/10.1053/j.ajkd.2021.02.327
UR  - http://hdl.handle.net/10044/1/92606
VL  - 78
ER  -
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