Imperial College London
Alternate

ProfessorEricAlton

Faculty of Medicine, National Heart & Lung Institute

Chair in Gene Therapy
 
 
 
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Contact

 

+44 (0)20 7594 7929e.alton

 
 
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Assistant

 

Miss Samia Soussi +44 (0)20 7594 7980

 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bayfield:2019:10.1183/23120541.00234-2018,
author = {Bayfield, KJ and Horsley, A and Alton, E and Irving, S and Bush, A and Davies, JC},
doi = {10.1183/23120541.00234-2018},
journal = {ERJ Open Research},
title = {Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes},
url = {http://dx.doi.org/10.1183/23120541.00234-2018},
volume = {5},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Multiple-breath washout (MBW) can be performed with different gases (sulfur hexafluoride (SF6-) and nitrogen (N2)) and different devices, all of which give discrepant results. This study aimed to confirm previously reported differences and explore factors influencing discrepant results; equipment factors or the physical properties of gases used. Methods: Healthy controls (HCs) and participants with cystic fibrosis (CF) completed MBW trials on two commercially available devices (Exhalyzer D (N2) and Innocor (SF6)). Simultaneous washout of both gases at the same time on the commercial equipment and simultaneous washouts using a respiratory mass spectrometer (RMS) were completed in subsets. Primary outcomes were lung clearance index (LCI), breath number and time required to washout. Results: Breath number was higher with N2 washout than SF6 in both HCs and patients with CF, whether washouts were completed individually or simultaneously. The difference was greater in more advanced disease, largely caused by differences in the final part of the washout. Results from commercial devices were similar to those obtained with the RMS. Conclusions: N2 MBW results were higher than SF6 MBW, with some of the largest differences reported to date being observed. The biggest impact was at the end of the washout and this was even the case when gases were washed out simultaneously. N2 and SF6 MBW results are inherently different and should be considered as independent measurements.
AU  - Bayfield,KJ
AU  - Horsley,A
AU  - Alton,E
AU  - Irving,S
AU  - Bush,A
AU  - Davies,JC
DO  - 10.1183/23120541.00234-2018
PY  - 2019///
SN  - 2312-0541
TI  - Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes
T2  - ERJ Open Research
UR  - http://dx.doi.org/10.1183/23120541.00234-2018
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31720295
UR  - http://hdl.handle.net/10044/1/75103
VL  - 5
ER  -
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