Imperial College London
Alternate

ProfessorEtienneBurdet

Faculty of Engineering, Department of Bioengineering

Professor of Human Robotics
 
 
 
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Contact

 

e.burdet Website

 
 
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Location

 

419BSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Allievi:2016:cercor/bhv203,
author = {Allievi, AG and Arichi, T and Tusor, N and Kimpton, J and Arulkumaran, S and Counsell, SJ and Edwards, AD and Burdet, E},
doi = {cercor/bhv203},
journal = {Cerebral Cortex},
title = {Maturation of Sensori-Motor Functional Responses in the Preterm Brain.},
url = {http://dx.doi.org/10.1093/cercor/bhv203},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Preterm birth engenders an increased risk of conditions like cerebral palsy and therefore this time may be crucial for the brain's developing sensori-motor system. However, little is known about how cortical sensori-motor function matures at this time, whether development is influenced by experience, and about its role in spontaneous motor behavior. We aimed to systematically characterize spatial and temporal maturation of sensori-motor functional brain activity across this period using functional MRI and a custom-made robotic stimulation device. We studied 57 infants aged from 30 + 2 to 43 + 2 weeks postmenstrual age. Following both induced and spontaneous right wrist movements, we saw consistent positive blood oxygen level-dependent functional responses in the contralateral (left) primary somatosensory and motor cortices. In addition, we saw a maturational trend toward faster, higher amplitude, and more spatially dispersed functional responses; and increasing integration of the ipsilateral hemisphere and sensori-motor associative areas. We also found that interhemispheric functional connectivity was significantly related to ex-utero exposure, suggesting the influence of experience-dependent mechanisms. At term equivalent age, we saw a decrease in both response amplitude and interhemispheric functional connectivity, and an increase in spatial specificity, culminating in the establishment of a sensori-motor functional response similar to that seen in adults.
AU  - Allievi,AG
AU  - Arichi,T
AU  - Tusor,N
AU  - Kimpton,J
AU  - Arulkumaran,S
AU  - Counsell,SJ
AU  - Edwards,AD
AU  - Burdet,E
DO  - cercor/bhv203
PY  - 2016///
SN  - 1460-2199
TI  - Maturation of Sensori-Motor Functional Responses in the Preterm Brain.
T2  - Cerebral Cortex
UR  - http://dx.doi.org/10.1093/cercor/bhv203
UR  - http://hdl.handle.net/10044/1/27132
ER  -
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