Dr Edward Chambers is a Research Fellow in the Nutrition and Dietetics Research Group. His applied in vivo human research aims to advance understanding of nutritional intervention in health and disease.
His main area of interest is investigating the interplay between dietary fibre and the composition and functional activities of the gut microbiome in the regulation of metabolic homeostasis in humans. At Imperial College London, his principal responsibility has been the conduct and management of BBSRC and NIHR BRC funded projects which have investigated the beneficial role of the gut-derived short chain fatty acid (SCFA) propionate to metabolic health. Published studies have developed in vivo proof-of-concept for propionate as a novel therapeutic to improve body weight management and reduce hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD).
et al., 2017, Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial, Lancet Diabetes & Endocrinology, Vol:5, ISSN:2213-8587, Pages:184-195
et al., 2017, The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro, Diabetes Obesity & Metabolism, Vol:19, ISSN:1462-8902, Pages:257-265
et al., 2017, Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans., Diabetes Obes Metab
et al., 2016, Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial, British Journal of Nutrition, Vol:116, ISSN:0007-1145, Pages:360-374
et al., 2016, Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods, American Journal of Clinical Nutrition, Vol:104, ISSN:0002-9165, Pages:5-14