Imperial College London
Alternate

ProfessorEmm MicDrakakis

Faculty of Engineering, Department of Bioengineering

Professor of Bio-Circuits and Systems
 
 
 
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Contact

 

e.drakakis Website

 
 
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Location

 

B207Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pagkalos:2017:10.1016/j.measurement.2017.02.009,
author = {Pagkalos, I and Drakakis, EM},
doi = {10.1016/j.measurement.2017.02.009},
journal = {Measurement},
pages = {249--252},
title = {An automatic transimpedance gain control circuit for analogue front-ends of drifting amperometric biosensors},
url = {http://dx.doi.org/10.1016/j.measurement.2017.02.009},
volume = {102},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - When  amperometric  biosensors  drift,  their  sensitivity  drops  with  time:the same difference in detected concentration value Cresults in lower sen-sor output current Ias the measurement/monitoring time progresses.  Thislimitation affects the longevity of biosensors.  To counterbalance for the dropin sensitivity, manual adjustment of the I-to-V transimpedance gain is usuallyapplied.  This paper presents an automatic transimpedance gain control cir-cuit suitable for switched-capacitor-based current analogue front-ends.  Thecircuit has been fabricated in the 0.35μmAMS technology, occupies an areaof 0.028mm2and consumes 14.5μWfrom a 3.3Vsupply.  Measured resultsconfirm the automatic selection between three values of transimpedance gain,namely  1,10  and  100G  each  optimised  for  sensor  current  range  values  of±1.65nA,±165pAand±16.5pArespectively.  Though the reported topologyhas been tailored for glucose/lactate amperometric biosensors of slow tem-poral dynamics, its parameters can be made to match the conditions of otherphysiological/physical processes in need of monitoring.
AU  - Pagkalos,I
AU  - Drakakis,EM
DO  - 10.1016/j.measurement.2017.02.009
EP  - 252
PY  - 2017///
SN  - 1873-412X
SP  - 249
TI  - An automatic transimpedance gain control circuit for analogue front-ends of drifting amperometric biosensors
T2  - Measurement
UR  - http://dx.doi.org/10.1016/j.measurement.2017.02.009
UR  - http://hdl.handle.net/10044/1/44413
VL  - 102
ER  -
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