Imperial College London

DrElaineFuertes

Faculty of MedicineNational Heart & Lung Institute

Imperial College Junior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 7939e.fuertes

 
 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

62 results found

Thiering E, Markevych I, Brueske I, Fuertes E, Kratzsch J, Sugiri D, Hoffmann B, von Berg A, Bauer C-P, Koletzko S, Berdel D, Heinrich Jet al., 2016, Associations of Residential Long-Term Air Pollution Exposures and Satellite-Derived Greenness with Insulin Resistance in German Adolescents, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 124, Pages: 1291-1298, ISSN: 0091-6765

Background: Epidemiological studies have identified associations between air pollution and green space access with type 2 diabetes in adults. However, it remains unclear to what extent associations with greenness are attributable to air pollution exposure.Objectives: We aimed to investigate associations between long-term exposure to air pollution and satellite-derived greenness with insulin resistance in adolescents.Methods: A total of 837 participants of two German birth cohorts (LISAplus and GINIplus) were included in the analysis. Generalized additive models were used to determine the association of individual satellite-derived greenness defined by the Normalized Difference Vegetation Index (NDVI), long-term air pollution exposure estimated by land-use regression (LUR) models with insulin resistance (HOMA-IR) in 15-year-old adolescents. Models were adjusted for study area, cohort, socioeconomic, and individual characteristics such as body mass index, physical activity, and smoking.Results: Increases of 2 SDs in nitrogen dioxide (NO2; 8.9 μg/m3) and particulate matter ≤ 10 μm in diameter (PM10; 6.7 μg/m3) were significantly associated with 11.4% (95% CI: 4.4, 18.9) and 11.4% (95% CI: 0.4, 23.7) higher HOMA-IR. A 2-SD increase in NDVI in a 1,000-m buffer (0.2 units) was significantly associated with a lower HOMA-IR (–7.4%; 95% CI: –13.3, –1.1). Associations tended to be stronger in adolescents who spent more time outside and in those with lower socioeconomic status. In combined models including both air pollution and greenness, only NO2 remained significantly associated with HOMA-IR, whereas effect estimates for all other exposures attenuated after adjustment for NO2.Conclusions: NO2, often considered as a marker of traffic, was independently associated with insulin resistance. The observed association between higher greenness exposure and lower HOMA-IR in adolescents might thus be attributable mainly to the lower co-exposure to traffi

Journal article

Gehring U, Wijga AH, Hoek G, Bellander T, Berdel D, Brueske I, Fuertes E, Gruzieva O, Heinrich J, Hoffmann B, de Jongste JC, Kluemper C, Koppelman GH, Korek M, Kraemer U, Maier D, Melen E, Pershagen G, Postma DS, Standl M, von Berg A, Anto JM, Bousquet J, Keil T, Smit HA, Brunekreef Bet al., 2015, Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study, LANCET RESPIRATORY MEDICINE, Vol: 3, Pages: 933-942, ISSN: 2213-2600

BackgroundPrevious published analyses have focused on the effect of air pollution on asthma and rhinoconjunctivitis throughout early and middle childhood. However, the role of exposure to air pollution in the development of childhood and adolescent asthma and rhinoconjunctivitis remains unclear. We aimed to assess the longitudinal associations between exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence.MethodsWe did a population-based birth cohort study of 14 126 participants from four prospective birth cohort studies from Germany, Sweden, and the Netherlands with 14–16 years of follow-up. We linked repeated questionnaire reports of asthma and rhinoconjunctivitis with annual average air pollution concentrations (nitrogen dioxide [NO2], particulate matter [PM] with a diameter of less than 2·5 μm [PM2·5], less than 10 μm [PM10], and between 2·5 μm and 10 μm [PMcoarse], and PM2·5 absorbance [indicator of soot]) at the participants' home addresses. We analysed longitudinal associations of air pollution exposure at participants' birth addresses and addresses at the time of follow-up with asthma and rhinoconjunctivitis incidence and prevalence in cohort-specific analyses, with subsequent meta-analysis and pooled analyses.FindingsOverall, the risk of incident asthma up to age 14–16 years increased with increasing exposure to NO2 (adjusted meta-analysis odds ratio [OR] 1·13 per 10 μg/m3 [95% CI 1·02–1·25]) and PM2·5 absorbance (1·29 per 1 unit [1·00–1·66]) at the birth address. A similar, albeit non-significant, trend was shown for PM2·5 and incident asthma (meta-analysis OR 1·25 per 5 μg/m3 [95% CI 0·94–1·66]). These associations with asthma were more consistent after age 4 years than before that age. There was no indication of an adverse effect of air pollution

Journal article

Fuertes E, Bracher J, Flexeder C, Markevych I, Kluemper C, Hoffmann B, Kraemer U, von Berg A, Bauer C-P, Koletzko S, Berdel D, Heinrich J, Schulz Het al., 2015, Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 218, Pages: 656-665, ISSN: 1438-4639

IntroductionThe impact of outdoor air pollution exposure on long-term lung development and potential periods of increased lung susceptibility remain unknown. This study assessed associations between early-life and current residential exposure to air pollution and lung function at 15-years of age in two German birth cohorts.MethodsFifteen year-old participants living in an urban and rural area in Germany underwent spirometry before and after bronchodilation (N = 2266). Annual average (long-term) exposure to nitrogen dioxide (NO2), particles with aerodynamic diameters less than 2.5 μg/m3 (PM2.5) mass and less than 10 μg/m3 (PM10) mass, PM2.5 absorbance and ozone were estimated to each participant's birth-, 10- and 15-year home address using land-use regression and kriging (ozone only) modelling. Associations between lung function variables and long-term pollutant concentrations were assessed using linear regression models adjusted for host and environmental covariates and recent short-term air pollution exposures.ResultsLong-term air pollution concentrations assessed to the birth-, 10- and 15-year home addresses were not associated with lung function variables, before and after bronchodilation, in the complete or study area specific populations. However, several lung function variables were negatively associated with long-term NO2 concentrations among asthmatics. For example, NO2 estimated to the 15-year home address was associated with the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) and the mean flow rate between 25% and 75% of FVC (−3.5%, 95% confidence interval [−6.0, −1.0] and −297.4 ml/s [−592.6, −2.1] per 5.9 μg/m3 increase in NO2, respectively). Nearly all effect estimates for the associations between the short-term PM2.5 mass, PM10 mass and ozone concentrations and the lung function variables were negative in the complete population.ConclusionsEarly-life and current long-term

Journal article

Fuertes E, Heinrich J, 2015, The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization, ALLERGY, Vol: 70, Pages: 1350-1351, ISSN: 0105-4538

Journal article

Fuertes E, Standl M, von Berg A, Lehmann I, Hoffmann B, Bauer C-P, Koletzko S, Berdel D, Heinrich Jet al., 2015, Parental allergic disease before and after child birth poses similar risk for childhood allergies, ALLERGY, Vol: 70, Pages: 873-876, ISSN: 0105-4538

Journal article

Moelter A, Simpson A, Berdel D, Brunekreef B, Custovic A, Cyrys J, de Jongste J, de Vocht F, Fuertes E, Gehring U, Gruzieva O, Heinrich J, Hoek G, Hoffmann B, Kluemper C, Korek M, Kuhlbusch TAJ, Lindley S, Postma D, Tischer C, Wijga A, Pershagen G, Agius Ret al., 2015, A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project, EUROPEAN RESPIRATORY JOURNAL, Vol: 45, Pages: 610-624, ISSN: 0903-1936

Journal article

Fuertes E, Soderhall C, Acevedo N, Becker A, Brauer M, Chan-Yeung M, Dijk FN, Heinrich J, de Jongste J, Koppelman GH, Postma DS, Kere J, Kozyrskyj AL, Pershagen G, Sandford A, Standl M, Tiesler CMT, Waldenberger M, Westman M, Carlsten C, Melen Eet al., 2015, Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 135, Pages: 573-+, ISSN: 0091-6749

Journal article

Liu C, Fuertes E, Flexeder C, Hofbauer LC, Berdel D, Hoffmann B, Kratzsch J, von Berg A, Heinrich Jet al., 2015, Associations between ambient air pollution and bone turnover markers in 10-year old children: Results from the GINIplus and LISAplus studies, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 218, Pages: 58-65, ISSN: 1438-4639

Journal article

Fuertes E, MacIntyre E, Agius R, Beelen R, Brunekreef B, Bucci S, Cesaroni G, Cirach M, Cyrys J, Forastiere F, Gehring U, Gruzieva O, Hoffmann B, Jedynska A, Keuken M, Kluemper C, Kooter I, Korek M, Kraemer U, Moelter A, Nieuwenhuijsen M, Pershagen G, Porta D, Postma DS, Simpson A, Smit HA, Sugiri D, Sunyer J, Wang M, Heinrich Jet al., 2014, Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: Results from the ESCAPE and TRANSPHORM projects, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 217, Pages: 819-829, ISSN: 1438-4639

Journal article

Fuertes E, Butland BK, Anderson HR, Carlsten C, Strachan DP, Brauer Met al., 2014, Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis, ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol: 113, Pages: 386-U88, ISSN: 1081-1206

Journal article

Markevych I, Tiesler CMT, Fuertes E, Romanos M, Dadvand P, Nieuwenhuijsen MJ, Berdel D, Koletzko S, Heinrich Jet al., 2014, Access to urban green spaces and behavioural problems in children: Results from the GINIplus and LISAplus studies, ENVIRONMENT INTERNATIONAL, Vol: 71, Pages: 29-35, ISSN: 0160-4120

Journal article

Eeftens M, Hoek G, Gruzieva O, Moelter A, Agius R, Beelen R, Brunekreef B, Custovic A, Cyrys J, Fuertes E, Heinrich J, Hoffmann B, de Hoogh K, Jedynska A, Keuken M, Kluemper C, Kooter I, Kraemer U, Korek M, Koppelman GH, Kuhlbusch TAJ, Simpson A, Smit HA, Tsai M-Y, Wang M, Wolf K, Pershagen G, Gehring Uet al., 2014, Elemental Composition of Particulate Matter and the Association with Lung Function, EPIDEMIOLOGY, Vol: 25, Pages: 648-657, ISSN: 1044-3983

Journal article

Pei Z, Flexeder C, Fuertes E, Standl M, Berdel D, von Berg A, Koletzko S, Schaaf B, Heinrich Jet al., 2014, Mother's body mass index and food intake in school-aged children: results of the GINIplus and the LISAplus studies, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 68, Pages: 898-906, ISSN: 0954-3007

Journal article

Fuertes E, Markevych I, von Berg A, Bauer C-P, Berdel D, Koletzko S, Sugiri D, Heinrich Jet al., 2014, Greenness and allergies: evidence of differential associations in two areas in Germany, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 68, Pages: 787-790, ISSN: 0143-005X

Journal article

Markevych I, Thiering E, Fuertes E, Sugiri D, Berdel D, Koletzko S, von Berg A, Bauer C-P, Heinrich Jet al., 2014, A cross-sectional analysis of the effects of residential greenness on blood pressure in 10-year old children: results from the GINIplus and LISAplus studies, BMC PUBLIC HEALTH, Vol: 14, ISSN: 1471-2458

Journal article

Pei Z, Heinrich J, Fuertes E, Flexeder C, Hoffmann B, Lehmann I, Schaaf B, von Berg A, Koletzko Set al., 2014, Cesarean Delivery and Risk of Childhood Obesity, JOURNAL OF PEDIATRICS, Vol: 164, Pages: 1068-+, ISSN: 0022-3476

Journal article

Liu C, Fuertes E, Tiesler CMT, Birk M, Babisch W, Bauer C-P, Koletzko S, von Berg A, Hoffmann B, Heinrich Jet al., 2014, The associations between traffic-related air pollution and noise with blood pressure in children: Results from the GINIplus and LISAplus studies, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 217, Pages: 499-505, ISSN: 1438-4639

Journal article

Liu C, Flexeder C, Fuertes E, Cyrys J, Bauer C-P, Koletzko S, Hoffmann B, von Berg A, Heinrich Jet al., 2014, Effects of air pollution on exhaled nitric oxide in children: Results from the GINIplus and LISAplus studies, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 217, Pages: 483-491, ISSN: 1438-4639

Journal article

MacIntyre EA, Brauer M, Melen E, Bauer CP, Bauer M, Berdel D, Bergstroem A, Brunekreef B, Chan-Yeung M, Kluemper C, Fuertes E, Gehring U, Gref A, Heinrich J, Herbarth O, Kerkhof M, Koppelman GH, Kozyrskyj AL, Pershagen G, Postma DS, Thiering E, Tiesler CMT, Carlsten Cet al., 2014, GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 122, Pages: 418-424, ISSN: 0091-6765

Journal article

Markevych I, Fuertes E, Tiesler CMT, Birk M, Bauer C-P, Koletzko S, von Berg A, Berdel D, Heinrich Jet al., 2014, Surrounding greenness and birth weight: Results from the GINIplus and LISAplus birth cohorts in Munich, HEALTH & PLACE, Vol: 26, Pages: 39-46, ISSN: 1353-8292

Journal article

Gruzieva O, Gehring U, Aalberse R, Agius R, Beelen R, Behrendt H, Bellander T, Birk M, de Jongste JC, Fuertes E, Heinrich J, Hoek G, Kluemper C, Koppelman G, Korek M, Kraemer U, Lindley S, Moelter A, Simpson A, Standl M, van Hage M, von Berg A, Wijga A, Brunekreef B, Pershagen Get al., 2014, Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 767-+, ISSN: 0091-6749

Journal article

MacIntyre EA, Gehring U, Moelter A, Fuertes E, Kluemper C, Kraemer U, Quass U, Hoffmann B, Gascon M, Brunekreef B, Koppelman GH, Beelen R, Hoek G, Birk M, de Jongste JC, Smit HA, Cyrys J, Gruzieva O, Korek M, Bergstrom A, Agius RM, de Vocht F, Simpson A, Porta D, Forastiere F, Badaloni C, Cesaroni G, Esplugues A, Fernandez-Somoano A, Lerxundi A, Sunyer J, Cirach M, Nieuwenhuijsen MJ, Pershagen G, Heinrich Jet al., 2014, Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 122, Pages: 107-113, ISSN: 0091-6765

Journal article

Pei Z, Flexeder C, Fuertes E, Standl M, Buyken A, Berdel D, von Berg A, Lehmann I, Schaaf B, Heinrich Jet al., 2014, Food Intake and Overweight in School-Aged Children in Germany: Resullts of the GINIplus and LISAplus Studies, ANNALS OF NUTRITION AND METABOLISM, Vol: 64, Pages: 60-70, ISSN: 0250-6807

Journal article

Gehring U, Gruzieva O, Agius RM, Beelen R, Custovic A, Cyrys J, Eeftens M, Flexeder C, Fuertes E, Heinrich J, Hoffmann B, de Jongste JC, Kerkhof M, Klümper C, Korek M, Mölter A, Schultz ES, Simpson A, Sugiri D, Svartengren M, von Berg A, Wijga AH, Pershagen G, Brunekreef Bet al., 2013, Air pollution exposure and lung function in children: the ESCAPE project., Environmental Health Perspectives, Vol: 121, Pages: 1357-1364, ISSN: 1552-9924

BACKGROUND: There is evidence for adverse effects of outdoor air pollution on lung function of children. Quantitative summaries of the effects of air pollution on lung function, however, are lacking due to large differences among studies. OBJECTIVES: We aimed to study the association between residential exposure to air pollution and lung function in five European birth cohorts with a standardized exposure assessment following a common protocol. METHODS: As part of the European Study of Cohorts for Air Pollution Effects (ESCAPE) we analyzed data from birth cohort studies situated in Germany, Sweden, the Netherlands, and the United Kingdom that measured lung function at 6-8 years of age (n = 5,921). Annual average exposure to air pollution [nitrogen oxides (NO2, NOx), mass concentrations of particulate matter with diameters < 2.5, < 10, and 2.5-10 μm (PM2.5, PM10, and PMcoarse), and PM2.5 absorbance] at the birth address and current address was estimated by land-use regression models. Associations of lung function with estimated air pollution levels and traffic indicators were estimated for each cohort using linear regression analysis, and then combined by random effects meta-analysis. RESULTS: Estimated levels of NO2, NOx, PM2.5 absorbance, and PM2.5 at the current address, but not at the birth address, were associated with small decreases in lung function. For example, changes in forced expiratory volume in 1 sec (FEV1) ranged from -0.86% (95% CI: -1.48, -0.24%) for a 20-μg/m3 increase in NOx to -1.77% (95% CI: -3.34, -0.18%) for a 5-μg/m3 increase in PM2.5. CONCLUSIONS: Exposure to air pollution may result in reduced lung function in schoolchildren.

Journal article

Fuertes E, Standl M, Cyrys J, Berdel D, von Berg A, Bauer C-P, Kraemer U, Sugiri D, Lehmann I, Koletzko S, Carlsten C, Brauer M, Heinrich Jet al., 2013, A longitudinal analysis of associations between traffic-related air pollution with asthma, allergies and sensitization in the GINIplus and LISAplus birth cohorts, PEERJ, Vol: 1, ISSN: 2167-8359

Journal article

Pei Z, Flexeder C, Fuertes E, Thiering E, Koletzko B, Cramer C, Berdel D, Lehmann I, Bauer C-P, Heinrich Jet al., 2013, Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 67, Pages: 855-862, ISSN: 0954-3007

Journal article

Fuertes E, Brauer M, MacIntyre E, Bauer M, Bellander T, von Berg A, Berdel D, Brunekreef B, Chan-Yeung M, Gehring U, Herbarth O, Hoffmann B, Kerkhof M, Kluemper C, Koletzko S, Kozyrskyj A, Kull I, Heinrich J, Melen E, Pershagen G, Postma D, Tiesler CMT, Carlsten Cet al., 2013, Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG Study, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 342-+, ISSN: 0091-6749

Journal article

MacIntyre EA, Carlsten C, MacNutt M, Fuertes E, Melen E, Tiesler CMT, Gehring U, Kraemer U, Kluemper C, Kerkhof M, Chan-Yeung M, Kozyrskyj AL, Berdel D, Bauer CP, Herbarth O, Bauer M, Schaaf B, Koletzko S, Pershagen G, Brunekreef B, Heinrich J, Brauer Met al., 2013, Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 28, Pages: 597-606, ISSN: 0393-2990

Journal article

Liu C, Fuertes E, Tiesler CMT, Birk M, Babisch W, Bauer C-P, Koletzko S, Heinrich Jet al., 2013, The association between road traffic noise exposure and blood pressure among children in Germany: The GINIplus and LISAplus studies, NOISE & HEALTH, Vol: 15, Pages: 165-172, ISSN: 1463-1741

Journal article

Jacobs JH, Fuertes E, Krop EJM, Spithoven J, Tromp P, Heederik DJJet al., 2012, Swimming pool attendance and respiratory symptoms and allergies among Dutch children, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 69, Pages: 823-830, ISSN: 1351-0711

Journal article

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