Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Imperial College Junior Research Fellow



+44 (0)20 7594 7939e.fuertes




Emmanuel Kaye BuildingRoyal Brompton Campus






BibTex format

author = {Fuertes, E and Sunyer, J and Gehring, U and Porta, D and Forastiere, F and Cesaroni, G and Vrijheid, M and Guxens, M and Annesi-Maesano, I and Slama, R and Maier, D and Kogevinas, M and Bousquet, J and Chatzi, L and Lertxundi, A and Basterrechea, M and Esplugues, A and Ferrero, A and Wright, J and Mason, D and McEachan, R and Garcia-Aymerich, J and Jacquemin, B},
doi = {10.1016/j.envint.2020.105474},
journal = {Environment International},
title = {Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: a meta-analysis of European birth cohorts},
url = {},
volume = {136},
year = {2020}

RIS format (EndNote, RefMan)

AB - BackgroundUncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades.ObjectiveWe examined associations of long-term air pollution levels at the home address with pediatric eczema, rhinoconjunctivitis and asthma prevalences in five birth cohorts (BIB, EDEN, GASPII, RHEA and INMA) from seven areas in five European countries.MethodsCurrent eczema, rhinoconjunctivitis and asthma were assessed in children aged four (N = 6527) and eight years (N = 2489). A multi-morbidity outcome (≥2 conditions versus none) was also defined. Individual outdoor levels of nitrogen dioxide (NO2), nitrogen oxides, mass of particulate matter with an aerodynamic diameter <10 μm (PM10), 10–2.5 μm (PMcoarse) and <2.5 μm (PM2.5), and PM2.5 absorbance were assigned to the birth, four- and eight-year home addresses using highly defined spatial air pollution exposure models. Cohort-specific cross-sectional associations were assessed using logistic regression models adjusted for demographic and environmental covariates and combined in a random effects meta-analysis.ResultsThe overall prevalence of pediatric eczema, rhinoconjunctivitis and asthma at four years was 15.4%, 5.9% and 12.4%. We found no increase in the prevalence of these outcomes at four or eight years with increasing air pollution exposure. For example, the meta-analysis adjusted odds ratios (95% confidence intervals) for eczema, rhinoconjunctivitis and asthma at four years were 0.94 (0.81, 1.09), 0.90 (0.75, 1.09), and 0.91 (0.74, 1.11), respectively, per 10 μg/m3 increase in NO2 at the birth address, and 1.00 (0.81, 1.23), 0.70 (0.49, 1.00) and 0.88 (0.54, 1.45), respectively, per 5 μg/m3 increase in PM2.5 at the birth address.DiscussionIn this large meta-analysis of five birth cohorts, we found no indication of adverse effects of long-term air pollution exposure on the prevalen
AU - Fuertes,E
AU - Sunyer,J
AU - Gehring,U
AU - Porta,D
AU - Forastiere,F
AU - Cesaroni,G
AU - Vrijheid,M
AU - Guxens,M
AU - Annesi-Maesano,I
AU - Slama,R
AU - Maier,D
AU - Kogevinas,M
AU - Bousquet,J
AU - Chatzi,L
AU - Lertxundi,A
AU - Basterrechea,M
AU - Esplugues,A
AU - Ferrero,A
AU - Wright,J
AU - Mason,D
AU - McEachan,R
AU - Garcia-Aymerich,J
AU - Jacquemin,B
DO - 10.1016/j.envint.2020.105474
PY - 2020///
SN - 0160-4120
TI - Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: a meta-analysis of European birth cohorts
T2 - Environment International
UR -
UR -
VL - 136
ER -