Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Imperial College Junior Research Fellow



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BibTex format

author = {Tischer, C and Dadvand, P and Basagana, X and Fuertes, E and Bergström, A and Gruzieva, O and Melen, E and Berdel, D and Heinrich, J and Koletzko, S and Markevych, I and Standl, M and Sugiri, D and Cirugeda, L and Estarlich, M and Fernández-Somoano, A and Ferrero, A and Ibarlueza, J and Lertxundi, A and Tardón, A and Sunyer, J and Anto, JM},
doi = {10.1016/j.envres.2017.11.013},
journal = {Environmental Research},
pages = {276--283},
title = {Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study.},
url = {},
volume = {161},
year = {2017}

RIS format (EndNote, RefMan)

AB - OBJECTIVE: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. METHODS: This study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires. We designed "environmental scores" corresponding to different indoor, green- and grey-related exposures (main analysis, a-priori-approach). Cohort-specific associations between these environmental scores and the respiratory health outcomes were assessed using random-effects meta-analyses. In addition, a factor analysis was performed based on the same exposure information used to develop the environmental scores (confirmatory analysis, data-driven-approach). RESULTS: A higher early exposure to the indoor environmental score increased the risk for wheezing and bronchitis within the first year of life (combined adjusted odds ratio: 1.20 [95% confidence interval: 1.13-1.27] and 1.28 [1.18-1.39], respectively). In contrast, there was an inverse association with allergic rhinitis between 6 and 8 years (0.85 [0.79-0.92]). There were no statistically significant associations for the outdoor related environmental scores in relation to any of the health outcomes tested. The factor analysis conducted confirmed these trends. CONCLUSION: Although a higher exposure to indoor related exposure through occupants was associated with an increased risk for wheezing and bronchitis within the 1st year, it might serve as a preventive mechanism against later childhood allergic respiratory outcomes in urbanized environments through enhanced shared contact with microbial agents.
AU - Tischer,C
AU - Dadvand,P
AU - Basagana,X
AU - Fuertes,E
AU - Bergström,A
AU - Gruzieva,O
AU - Melen,E
AU - Berdel,D
AU - Heinrich,J
AU - Koletzko,S
AU - Markevych,I
AU - Standl,M
AU - Sugiri,D
AU - Cirugeda,L
AU - Estarlich,M
AU - Fernández-Somoano,A
AU - Ferrero,A
AU - Ibarlueza,J
AU - Lertxundi,A
AU - Tardón,A
AU - Sunyer,J
AU - Anto,JM
DO - 10.1016/j.envres.2017.11.013
EP - 283
PY - 2017///
SN - 0013-9351
SP - 276
TI - Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study.
T2 - Environmental Research
UR -
UR -
UR -
VL - 161
ER -