Imperial College London

DrElaineFuertes

Faculty of MedicineNational Heart & Lung Institute

Imperial College Junior Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 7939e.fuertes

 
 
//

Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Fuertes:2015:10.1016/j.ijheh.2015.07.003,
author = {Fuertes, E and Bracher, J and Flexeder, C and Markevych, I and Kluemper, C and Hoffmann, B and Kraemer, U and von, Berg A and Bauer, C-P and Koletzko, S and Berdel, D and Heinrich, J and Schulz, H},
doi = {10.1016/j.ijheh.2015.07.003},
journal = {INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH},
pages = {656--665},
title = {Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts},
url = {http://dx.doi.org/10.1016/j.ijheh.2015.07.003},
volume = {218},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - IntroductionThe impact of outdoor air pollution exposure on long-term lung development and potential periods of increased lung susceptibility remain unknown. This study assessed associations between early-life and current residential exposure to air pollution and lung function at 15-years of age in two German birth cohorts.MethodsFifteen year-old participants living in an urban and rural area in Germany underwent spirometry before and after bronchodilation (N = 2266). Annual average (long-term) exposure to nitrogen dioxide (NO2), particles with aerodynamic diameters less than 2.5 μg/m3 (PM2.5) mass and less than 10 μg/m3 (PM10) mass, PM2.5 absorbance and ozone were estimated to each participant's birth-, 10- and 15-year home address using land-use regression and kriging (ozone only) modelling. Associations between lung function variables and long-term pollutant concentrations were assessed using linear regression models adjusted for host and environmental covariates and recent short-term air pollution exposures.ResultsLong-term air pollution concentrations assessed to the birth-, 10- and 15-year home addresses were not associated with lung function variables, before and after bronchodilation, in the complete or study area specific populations. However, several lung function variables were negatively associated with long-term NO2 concentrations among asthmatics. For example, NO2 estimated to the 15-year home address was associated with the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) and the mean flow rate between 25% and 75% of FVC (−3.5%, 95% confidence interval [−6.0, −1.0] and −297.4 ml/s [−592.6, −2.1] per 5.9 μg/m3 increase in NO2, respectively). Nearly all effect estimates for the associations between the short-term PM2.5 mass, PM10 mass and ozone concentrations and the lung function variables were negative in the complete population.ConclusionsEarly-life and current long-term
AU - Fuertes,E
AU - Bracher,J
AU - Flexeder,C
AU - Markevych,I
AU - Kluemper,C
AU - Hoffmann,B
AU - Kraemer,U
AU - von,Berg A
AU - Bauer,C-P
AU - Koletzko,S
AU - Berdel,D
AU - Heinrich,J
AU - Schulz,H
DO - 10.1016/j.ijheh.2015.07.003
EP - 665
PY - 2015///
SN - 1438-4639
SP - 656
TI - Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts
T2 - INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
UR - http://dx.doi.org/10.1016/j.ijheh.2015.07.003
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000375731300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/60001
VL - 218
ER -