Publications
91 results found
Fuertes E, Heinrich J, 2015, The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization, ALLERGY, Vol: 70, Pages: 1350-1351, ISSN: 0105-4538
Fuertes E, Bracher J, Flexeder C, et al., 2015, Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 218, Pages: 656-665, ISSN: 1438-4639
IntroductionThe impact of outdoor air pollution exposure on long-term lung development and potential periods of increased lung susceptibility remain unknown. This study assessed associations between early-life and current residential exposure to air pollution and lung function at 15-years of age in two German birth cohorts.MethodsFifteen year-old participants living in an urban and rural area in Germany underwent spirometry before and after bronchodilation (N = 2266). Annual average (long-term) exposure to nitrogen dioxide (NO2), particles with aerodynamic diameters less than 2.5 μg/m3 (PM2.5) mass and less than 10 μg/m3 (PM10) mass, PM2.5 absorbance and ozone were estimated to each participant's birth-, 10- and 15-year home address using land-use regression and kriging (ozone only) modelling. Associations between lung function variables and long-term pollutant concentrations were assessed using linear regression models adjusted for host and environmental covariates and recent short-term air pollution exposures.ResultsLong-term air pollution concentrations assessed to the birth-, 10- and 15-year home addresses were not associated with lung function variables, before and after bronchodilation, in the complete or study area specific populations. However, several lung function variables were negatively associated with long-term NO2 concentrations among asthmatics. For example, NO2 estimated to the 15-year home address was associated with the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) and the mean flow rate between 25% and 75% of FVC (−3.5%, 95% confidence interval [−6.0, −1.0] and −297.4 ml/s [−592.6, −2.1] per 5.9 μg/m3 increase in NO2, respectively). Nearly all effect estimates for the associations between the short-term PM2.5 mass, PM10 mass and ozone concentrations and the lung function variables were negative in the complete population.ConclusionsEarly-life and current long-term
Gref A, Merid SK, Gruzieva O, et al., 2015, An integrative genomics approach identifies new asthma pathways related to air pollution exposure, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Fuertes E, Standl M, von Berg A, et al., 2015, Parental allergic disease before and after child birth poses similar risk for childhood allergies, ALLERGY, Vol: 70, Pages: 873-876, ISSN: 0105-4538
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- Citations: 16
Moelter A, Simpson A, Berdel D, et al., 2015, A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project, European Respiratory Journal, Vol: 45, Pages: 610-624, ISSN: 0903-1936
The aim of this study was to determine the effect of six traffic-related air pollution metrics (nitrogen dioxide, nitrogen oxides, particulate matter with an aerodynamic diameter <10 μm (PM10), PM2.5, coarse particulate matter and PM2.5 absorbance) on childhood asthma and wheeze prevalence in five European birth cohorts: MAAS (England, UK), BAMSE (Sweden), PIAMA (the Netherlands), GINI and LISA (both Germany, divided into north and south areas).Land-use regression models were developed for each study area and used to estimate outdoor air pollution exposure at the home address of each child. Information on asthma and current wheeze prevalence at the ages of 4–5 and 8–10 years was collected using validated questionnaires. Multiple logistic regression was used to analyse the association between pollutant exposure and asthma within each cohort. Random-effects meta-analyses were used to combine effect estimates from individual cohorts.The meta-analyses showed no significant association between asthma prevalence and air pollution exposure (e.g. adjusted OR (95%CI) for asthma at age 8–10 years and exposure at the birth address (n=10377): 1.10 (0.81–1.49) per 10 μg·m-3 nitrogen dioxide; 0.88 (0.63–1.24) per 10 μg·m-3 PM10; 1.23 (0.78–1.95) per 5 μg·m-3 PM2.5). This result was consistently found in initial crude models, adjusted models and further sensitivity analyses.This study found no significant association between air pollution exposure and childhood asthma prevalence in five European birth cohorts.
Fuertes E, Soderhall C, Acevedo N, et al., 2015, Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 135, Pages: 573-+, ISSN: 0091-6749
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- Citations: 12
Liu C, Fuertes E, Flexeder C, et al., 2015, Associations between ambient air pollution and bone turnover markers in 10-year old children: Results from the GINIplus and LISAplus studies, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 218, Pages: 58-65, ISSN: 1438-4639
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- Citations: 17
Fuertes E, MacIntyre E, Agius R, et al., 2014, Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: Results from the ESCAPE and TRANSPHORM projects, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 217, Pages: 819-829, ISSN: 1438-4639
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- Citations: 31
Fuertes E, Butland BK, Anderson HR, et al., 2014, Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis, ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol: 113, Pages: 386-U88, ISSN: 1081-1206
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- Citations: 28
Markevych I, Tiesler CMT, Fuertes E, et al., 2014, Access to urban green spaces and behavioural problems in children: Results from the GINIplus and LISAplus studies, ENVIRONMENT INTERNATIONAL, Vol: 71, Pages: 29-35, ISSN: 0160-4120
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- Citations: 150
Eeftens M, Hoek G, Gruzieva O, et al., 2014, Elemental Composition of Particulate Matter and the Association with Lung Function, EPIDEMIOLOGY, Vol: 25, Pages: 648-657, ISSN: 1044-3983
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- Citations: 51
Fuertes E, Markevych I, von Berg A, et al., 2014, Greenness and allergies: evidence of differential associations in two areas in Germany, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 68, Pages: 787-790, ISSN: 0143-005X
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- Citations: 80
Pei Z, Flexeder C, Fuertes E, et al., 2014, Mother's body mass index and food intake in school-aged children: results of the GINIplus and the LISAplus studies, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 68, Pages: 898-906, ISSN: 0954-3007
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- Citations: 9
Markevych I, Thiering E, Fuertes E, et al., 2014, A cross-sectional analysis of the effects of residential greenness on blood pressure in 10-year old children: results from the GINIplus and LISAplus studies, BMC PUBLIC HEALTH, Vol: 14, ISSN: 1471-2458
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- Citations: 92
Pei Z, Heinrich J, Fuertes E, et al., 2014, Cesarean Delivery and Risk of Childhood Obesity, JOURNAL OF PEDIATRICS, Vol: 164, Pages: 1068-+, ISSN: 0022-3476
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- Citations: 70
MacIntyre EA, Brauer M, Melen E, et al., 2014, <i>GSTP1</i> and <i>TNF</i> Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 122, Pages: 418-424, ISSN: 0091-6765
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- Citations: 63
Markevych I, Fuertes E, Tiesler CMT, et al., 2014, Surrounding greenness and birth weight: Results from the GINIplus and LISAplus birth cohorts in Munich, HEALTH & PLACE, Vol: 26, Pages: 39-46, ISSN: 1353-8292
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- Citations: 90
Gruzieva O, Gehring U, Aalberse R, et al., 2014, Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 767-+, ISSN: 0091-6749
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- Citations: 57
MacIntyre EA, Gehring U, Moelter A, et al., 2014, Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 122, Pages: 107-113, ISSN: 0091-6765
Pei Z, Flexeder C, Fuertes E, et al., 2014, Food Intake and Overweight in School-Aged Children in Germany: Resullts of the GINIplus and LISAplus Studies, ANNALS OF NUTRITION AND METABOLISM, Vol: 64, Pages: 60-70, ISSN: 0250-6807
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- Citations: 14
Gehring U, Gruzieva O, Agius RM, et al., 2013, Air pollution exposure and lung function in children: the ESCAPE project., Environmental Health Perspectives, Vol: 121, Pages: 1357-1364, ISSN: 1552-9924
BACKGROUND: There is evidence for adverse effects of outdoor air pollution on lung function of children. Quantitative summaries of the effects of air pollution on lung function, however, are lacking due to large differences among studies. OBJECTIVES: We aimed to study the association between residential exposure to air pollution and lung function in five European birth cohorts with a standardized exposure assessment following a common protocol. METHODS: As part of the European Study of Cohorts for Air Pollution Effects (ESCAPE) we analyzed data from birth cohort studies situated in Germany, Sweden, the Netherlands, and the United Kingdom that measured lung function at 6-8 years of age (n = 5,921). Annual average exposure to air pollution [nitrogen oxides (NO2, NOx), mass concentrations of particulate matter with diameters < 2.5, < 10, and 2.5-10 μm (PM2.5, PM10, and PMcoarse), and PM2.5 absorbance] at the birth address and current address was estimated by land-use regression models. Associations of lung function with estimated air pollution levels and traffic indicators were estimated for each cohort using linear regression analysis, and then combined by random effects meta-analysis. RESULTS: Estimated levels of NO2, NOx, PM2.5 absorbance, and PM2.5 at the current address, but not at the birth address, were associated with small decreases in lung function. For example, changes in forced expiratory volume in 1 sec (FEV1) ranged from -0.86% (95% CI: -1.48, -0.24%) for a 20-μg/m3 increase in NOx to -1.77% (95% CI: -3.34, -0.18%) for a 5-μg/m3 increase in PM2.5. CONCLUSIONS: Exposure to air pollution may result in reduced lung function in schoolchildren.
Fuertes E, Standl M, Cyrys J, et al., 2013, A longitudinal analysis of associations between traffic-related air pollution with asthma, allergies and sensitization in the GINIplus and LISAplus birth cohorts, PEERJ, Vol: 1, ISSN: 2167-8359
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- Citations: 60
Liu C, Fuertes E, Tiesler CMT, et al., 2013, The associations between traffic-related air pollution and noise with blood pressure in children: Results from the GINIplus and LISAplus studies, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 217, Pages: 499-505, ISSN: 1438-4639
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- Citations: 72
Liu C, Flexeder C, Fuertes E, et al., 2013, Effects of air pollution on exhaled nitric oxide in children: Results from the GINIplus and LISAplus studies, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol: 217, Pages: 483-491, ISSN: 1438-4639
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- Citations: 18
Fuertes E, Brauer M, MacIntyre E, et al., 2013, Childhood allergic rhinitis, traffic-related air pollution, and variability in the <i>GSTP1</i>, <i>TNF</i>, <i>TLR2</i>, and <i>TLR4</i> genes: Results from the TAG Study, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 342-+, ISSN: 0091-6749
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- Citations: 68
Pei Z, Flexeder C, Fuertes E, et al., 2013, Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 67, Pages: 855-862, ISSN: 0954-3007
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- Citations: 20
MacIntyre EA, Carlsten C, MacNutt M, et al., 2013, Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 28, Pages: 597-606, ISSN: 0393-2990
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- Citations: 17
Liu C, Fuertes E, Tiesler CMT, et al., 2013, The association between road traffic noise exposure and blood pressure among children in Germany: The GINIplus and LISAplus studies, NOISE & HEALTH, Vol: 15, Pages: 165-172, ISSN: 1463-1741
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- Citations: 14
Jacobs JH, Fuertes E, Krop EJM, et al., 2012, Swimming pool attendance and respiratory symptoms and allergies among Dutch children, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 69, Pages: 823-830, ISSN: 1351-0711
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- Citations: 26
McKay RM, Vrbova L, Fuertes E, et al., 2011, Evaluation of the Do Bugs Need Drugs? program in British Columbia: Can we curb antibiotic prescribing?, CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY, Vol: 22, Pages: 19-24, ISSN: 1712-9532
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- Citations: 26
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