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@article{Carsin:2020:aje/kwaa087,
author = {Carsin, A-E and Keidel, D and Fuertes, E and Imboden, M and Weyler, J and Nowak, D and Heinrich, J and Pascual, Erquicia S and Martinez-Moratalla, J and Huerta, I and Sanchez, J-L and Schaffner, E and Caviezel, S and Beckmeyer-Borowko, A and Raherison, C and Pin, I and Demoly, P and Leynaert, B and Cerveri, I and Squillacioti, G and Accordini, S and Gislason, T and Svanes, C and Toren, K and Forsberg, B and Janson, C and Jogi, R and Emtner, M and Gómez, Real F and Jarvis, D and Guerra, S and Dharmage, SC and Probst-Hensch, N and Garcia-Aymerich, J},
doi = {aje/kwaa087},
journal = {American Journal of Epidemiology},
pages = {1521--1528},
title = {Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts},
url = {http://dx.doi.org/10.1093/aje/kwaa087},
volume = {189},
year = {2020}
}

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TY  - JOUR
AB  - A restrictive spirometry pattern is associated with high morbidity and mortality. Whether practicing regular physical activity protects against this pattern has never been studied. We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and physical activity were assessed between 2000–2002 in the ECRHS (n=2,757, 39-67 years) and SAPALDIA (n=2,610, 36–82 years) population-based European cohorts, and again approximately 10-years later (2010–2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active ≥2-3 times/wk for ≥1 h) with restrictive spirometry pattern at follow-up (defined as a post-bronchodilator FEV1/FVC ≥Lower Limit of Normal and FVC<80% predicted) using modified Poisson regression, adjusting for relevant confounders. After 10 years of follow-up, 3.3% of participants had developed restrictive spirometry pattern. Being physically active was associated with a lower risk of developing this phenotype (RR=0.76, 95% CI=0.59-0.98). This association was stronger among those overweight and obese, compared to those with normal weight (Pinteraction=0.06). In two large European studies, adults practicing regular physical activity were at lower risk of developing restrictive spirometry pattern after 10 years.
AU  - Carsin,A-E
AU  - Keidel,D
AU  - Fuertes,E
AU  - Imboden,M
AU  - Weyler,J
AU  - Nowak,D
AU  - Heinrich,J
AU  - Pascual,Erquicia S
AU  - Martinez-Moratalla,J
AU  - Huerta,I
AU  - Sanchez,J-L
AU  - Schaffner,E
AU  - Caviezel,S
AU  - Beckmeyer-Borowko,A
AU  - Raherison,C
AU  - Pin,I
AU  - Demoly,P
AU  - Leynaert,B
AU  - Cerveri,I
AU  - Squillacioti,G
AU  - Accordini,S
AU  - Gislason,T
AU  - Svanes,C
AU  - Toren,K
AU  - Forsberg,B
AU  - Janson,C
AU  - Jogi,R
AU  - Emtner,M
AU  - Gómez,Real F
AU  - Jarvis,D
AU  - Guerra,S
AU  - Dharmage,SC
AU  - Probst-Hensch,N
AU  - Garcia-Aymerich,J
DO  - aje/kwaa087
EP  - 1528
PY  - 2020///
SN  - 0002-9262
SP  - 1521
TI  - Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts
T2  - American Journal of Epidemiology
UR  - http://dx.doi.org/10.1093/aje/kwaa087
UR  - https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaa087/5854065
UR  - http://hdl.handle.net/10044/1/79871
VL  - 189
ER  -

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