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@article{Fuertes:2017:10.1016/j.jid.2017.02.966,
author = {Fuertes, E and Flohr, C and Silverberg, JI and Standl, M and Strachan, DP},
doi = {10.1016/j.jid.2017.02.966},
journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
pages = {1248--1256},
title = {Global Associations between UVR Exposure and Current Eczema Prevalence in Children from ISAAC Phase Three},
url = {http://dx.doi.org/10.1016/j.jid.2017.02.966},
volume = {137},
year = {2017}
}

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TY  - JOUR
AB  - We sought to examine the relationship globally between UVR dose exposure and current eczema prevalences. ISAAC Phase Three provided data on eczema prevalence for 13- to 14-year-olds in 214 centers in 87 countries and for 6- to 7-year-olds in 132 centers in 57 countries. Linear and nonlinear associations between (natural log transformed) eczema prevalence and the mean, maximum, minimum, standard deviation, and range of monthly UV dose exposures were assessed using linear mixed-effects regression models. For the 13- to 14-year-olds, the country-level eczema prevalence was positively and linearly associated with country-level monthly mean (prevalence ratio = 1.31 [95% confidence interval = 1.05–1.63] per kJ/m2) and minimum (1.25 [1.06–1.47] per kJ/m2) UVR dose exposure. Linear and nonlinear associations were also observed for other metrics of UV. Results were similar in trend, but nonsignificant, for the fewer centers with 6- to 7-year-olds (e.g., 1.24 [0.96–1.59] per kJ/m2 for country-level monthly mean UVR). No consistent within-country associations were observed (e.g., 1.05 [0.89–1.23] and 0.92 [0.71–1.18] per kJ/m2 for center-level monthly mean UVR for the 13- to 14- and 6- to 7-year-olds, respectively). These ecological results support a role for UVR exposure in explaining some of the variation in global childhood eczema prevalence.
AU  - Fuertes,E
AU  - Flohr,C
AU  - Silverberg,JI
AU  - Standl,M
AU  - Strachan,DP
DO  - 10.1016/j.jid.2017.02.966
EP  - 1256
PY  - 2017///
SN  - 0022-202X
SP  - 1248
TI  - Global Associations between UVR Exposure and Current Eczema Prevalence in Children from ISAAC Phase Three
T2  - JOURNAL OF INVESTIGATIVE DERMATOLOGY
UR  - http://dx.doi.org/10.1016/j.jid.2017.02.966
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401616900015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/59998
VL  - 137
ER  -

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