Imperial College London
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DrElaineFuertes

Faculty of Medicine, National Heart & Lung Institute

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 7939e.fuertes

 
 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gehring:2015:10.1016/S2213-2600(15)00426-9,
author = {Gehring, U and Wijga, AH and Hoek, G and Bellander, T and Berdel, D and Brueske, I and Fuertes, E and Gruzieva, O and Heinrich, J and Hoffmann, B and de, Jongste JC and Kluemper, C and Koppelman, GH and Korek, M and Kraemer, U and Maier, D and Melen, E and Pershagen, G and Postma, DS and Standl, M and von, Berg A and Anto, JM and Bousquet, J and Keil, T and Smit, HA and Brunekreef, B},
doi = {10.1016/S2213-2600(15)00426-9},
journal = {LANCET RESPIRATORY MEDICINE},
pages = {933--942},
title = {Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study},
url = {http://dx.doi.org/10.1016/S2213-2600(15)00426-9},
volume = {3},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPrevious published analyses have focused on the effect of air pollution on asthma and rhinoconjunctivitis throughout early and middle childhood. However, the role of exposure to air pollution in the development of childhood and adolescent asthma and rhinoconjunctivitis remains unclear. We aimed to assess the longitudinal associations between exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence.MethodsWe did a population-based birth cohort study of 14126 participants from four prospective birth cohort studies from Germany, Sweden, and the Netherlands with 14–16 years of follow-up. We linked repeated questionnaire reports of asthma and rhinoconjunctivitis with annual average air pollution concentrations (nitrogen dioxide [NO2], particulate matter [PM] with a diameter of less than 2·5 μm [PM2·5], less than 10 μm [PM10], and between 2·5 μm and 10 μm [PMcoarse], and PM2·5 absorbance [indicator of soot]) at the participants' home addresses. We analysed longitudinal associations of air pollution exposure at participants' birth addresses and addresses at the time of follow-up with asthma and rhinoconjunctivitis incidence and prevalence in cohort-specific analyses, with subsequent meta-analysis and pooled analyses.FindingsOverall, the risk of incident asthma up to age 14–16 years increased with increasing exposure to NO2 (adjusted meta-analysis odds ratio [OR] 1·13 per 10 μg/m3 [95% CI 1·02–1·25]) and PM2·5 absorbance (1·29 per 1 unit [1·00–1·66]) at the birth address. A similar, albeit non-significant, trend was shown for PM2·5 and incident asthma (meta-analysis OR 1·25 per 5 μg/m3 [95% CI 0·94–1·66]). These associations with asthma were more consistent after age 4 years than before that age. There was no indication of an adverse effect of air pollution
AU  - Gehring,U
AU  - Wijga,AH
AU  - Hoek,G
AU  - Bellander,T
AU  - Berdel,D
AU  - Brueske,I
AU  - Fuertes,E
AU  - Gruzieva,O
AU  - Heinrich,J
AU  - Hoffmann,B
AU  - de,Jongste JC
AU  - Kluemper,C
AU  - Koppelman,GH
AU  - Korek,M
AU  - Kraemer,U
AU  - Maier,D
AU  - Melen,E
AU  - Pershagen,G
AU  - Postma,DS
AU  - Standl,M
AU  - von,Berg A
AU  - Anto,JM
AU  - Bousquet,J
AU  - Keil,T
AU  - Smit,HA
AU  - Brunekreef,B
DO  - 10.1016/S2213-2600(15)00426-9
EP  - 942
PY  - 2015///
SN  - 2213-2600
SP  - 933
TI  - Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study
T2  - LANCET RESPIRATORY MEDICINE
UR  - http://dx.doi.org/10.1016/S2213-2600(15)00426-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000365817900031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/59799
VL  - 3
ER  -
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