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@article{Fuertes:2016:10.1111/all.12915,
author = {Fuertes, E and Markevych, I and Bowatte, G and Gruzieva, O and Gehring, U and Becker, A and Berdel, D and von, Berg A and Bergstrom, A and Brauer, M and Brunekreef, B and Brueske, I and Carlsten, C and Chan-Yeung, M and Dharmage, SC and Hoffmann, B and Kluemper, C and Koppelman, GH and Kozyrskyj, A and Korek, M and Kull, I and Lodge, C and Lowe, A and MacIntyre, E and Pershagen, G and Standl, M and Sugiri, D and Wijga, A and Heinrich, J},
doi = {10.1111/all.12915},
journal = {ALLERGY},
pages = {1461--1471},
title = {Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts},
url = {http://dx.doi.org/10.1111/all.12915},
volume = {71},
year = {2016}
}

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TY  - JOUR
AB  - BackgroundThe prevalence of allergic rhinitis is high, but the role of environmental factors remains unclear. We examined cohortspecific and combined associations of residential greenness with allergic rhinitis and aeroallergen sensitization based on individual data from Swedish (BAMSE), Australian (MACS), Dutch (PIAMA), Canadian (CAPPS and SAGE), and German (GINIplus and LISAplus) birth cohorts (n = 13 016).MethodsAllergic rhinitis (doctor diagnosis/symptoms) and aeroallergen sensitization were assessed in children aged 6–8 years in six cohorts and 10–12 years in five cohorts. Residential greenness was defined as the mean Normalized Difference Vegetation Index (NDVI) in a 500m buffer around the home address at the time of health assessment. Cohortspecific associations per 0.2 unit increase in NDVI were assessed using logistic regression models and combined in a randomeffects metaanalysis.ResultsGreenness in a 500m buffer was positively associated with allergic rhinitis at 6–8 years in BAMSE (odds ratio = 1.42, 95% confidence interval [1.13, 1.79]) and GINI/LISA South (1.69 [1.19, 2.41]) but inversely associated in GINI/LISA North (0.61 [0.36, 1.01]) and PIAMA (0.67 [0.47, 0.95]). Effect estimates in CAPPS and SAGE were also conflicting but not significant (0.63 [0.32, 1.24] and 1.31 [0.81, 2.12], respectively). All metaanalyses were nonsignificant. Results were similar for aeroallergen sensitization at 6–8 years and both outcomes at 10–12 years. Stratification by NO2 concentrations, population density, an urban vs rural marker, and moving did not reveal consistent trends within subgroups.ConclusionAlthough residential greenness appears to be associated with childhood allergic rhinitis and aeroallergen sensitization, the effect direction varies by location.
AU  - Fuertes,E
AU  - Markevych,I
AU  - Bowatte,G
AU  - Gruzieva,O
AU  - Gehring,U
AU  - Becker,A
AU  - Berdel,D
AU  - von,Berg A
AU  - Bergstrom,A
AU  - Brauer,M
AU  - Brunekreef,B
AU  - Brueske,I
AU  - Carlsten,C
AU  - Chan-Yeung,M
AU  - Dharmage,SC
AU  - Hoffmann,B
AU  - Kluemper,C
AU  - Koppelman,GH
AU  - Kozyrskyj,A
AU  - Korek,M
AU  - Kull,I
AU  - Lodge,C
AU  - Lowe,A
AU  - MacIntyre,E
AU  - Pershagen,G
AU  - Standl,M
AU  - Sugiri,D
AU  - Wijga,A
AU  - Heinrich,J
DO  - 10.1111/all.12915
EP  - 1471
PY  - 2016///
SN  - 0105-4538
SP  - 1461
TI  - Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts
T2  - ALLERGY
UR  - http://dx.doi.org/10.1111/all.12915
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000386085800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/59798
VL  - 71
ER  -

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