Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Structural Matrix Biology



+44 (0)20 7594 7701e.hohenester




406Sir Ernst Chain BuildingSouth Kensington Campus





Erhard Hohenester is a structural biologist investigating the biosynthesis, assembly and function of extracellular matrix. He trained as a chemist in his native Austria and received his PhD in Biophysics from the University of Basel (Switzerland) in 1995. He joined Imperial College London in 1998 with a Wellcome Trust Senior Research Fellowship, which he held for 15 years. In 2009 he was promoted to Professor of Structural Matrix Biology. His current research is funded by a Wellcome Trust Senior Investigator Award.

Group members

Dr Marta Busse-Wicher (Postdoc)

Dr Patricia Paracuellos (Postdoc)

Ms Sadaf-Ahmahni Hussain (Technician)

Mr Doug Sammon (PhD Student)

Selected Publications

Journal Articles

Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1., Structure, Vol:26, ISSN:0969-2126, Pages:801-809.e3

Pulido D, Hussain S-A, Hohenester E, 2017, Crystal Structure of the Heterotrimeric Integrin-Binding Region of Laminin-111, Structure, Vol:25, ISSN:0969-2126, Pages:530-535

Briggs DC, Yoshida-Moriguchi T, Zheng T, et al., 2016, Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology, Vol:12, ISSN:1552-4450, Pages:810-+

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