Erhard Hohenester is a structural biologist investigating the biosynthesis, assembly and function of extracellular matrix. He is best known for his work on laminins – huge glycoproteins that are an essential component of basement membranes. His current research focuses on the enzymes involved in glycosaminoglycan biosynthesis. Erhard trained as a chemist in his native Austria and received his PhD in Biophysics from the University of Basel (Switzerland) in 1995. He joined Imperial College London in 1998 with a Wellcome Trust Senior Research Fellowship, which he held for 15 years. He currently is Director of Research in the Department of Life Sciences.
Sammon D, Hohenester E, Leitinger B, 2020, Two-step release of kinase autoinhibition in discoidin domain receptor 1, Proceedings of the National Academy of Sciences of the United States of America, Vol:117, ISSN:0027-8424, Pages:22051-22060
Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1., Structure, Vol:26, ISSN:0969-2126, Pages:801-809.e3
Pulido D, Hussain S, Hohenester E, 2017, Crystal structure of the heterotrimeric integrin-binding region of laminin-111, Structure, Vol:25, ISSN:1878-4186, Pages:530-535
et al., 2016, Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology, Vol:12, ISSN:1552-4469, Pages:810-814