143 results found
Camacho N, Van Loo P, Edwards S, et al., 2017, Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data., PLoS Genet, Vol: 13
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation in prostate cancer. 64 recurrent regions of loss and gain were detected, of which 28 were novel, including regions of loss with more than 15% frequency at Chr4p15.2-p15.1 (15.53%), Chr6q27 (16.50%) and Chr18q12.3 (17.48%). Comprehensive mutation screens of genes, lincRNA encoding sequences, control regions and conserved domains within SCNAs demonstrated that a two-hit genetic model was supported in only a minor proportion of recurrent SCNA losses examined (15/40). We found that recurrent breakpoints and regions of inversion often occur within Knudson model SCNAs, leading to the identification of ZNF292 as a target gene for the deletion at 6q14.3-q15 and NKX3.1 as a two-hit target at 8p21.3-p21.2. The importance of alterations of lincRNA sequences was illustrated by the identification of a novel mutational hotspot at the KCCAT42, FENDRR, CAT1886 and STCAT2 loci at the 16q23.1-q24.3 loss. Our data confirm that the burden of SCNAs is predictive of biochemical recurrence, define nine individual regions that are associated with relapse, and highlight the possible importance of ion channel and G-protein coupled-receptor (GPCR) pathways in cancer development. We concluded that a two-hit genetic model accounts for about one third of SCNA indicating that mechanisms, such haploinsufficiency and epigenetic inactivation, account for the remaining SCNA losses.
Camara M, Mayer E, Darzi A, et al., 2017, Simulation of Patient-Specific Deformable Ultrasound Imaging in Real Time, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol: 10549 LNCS, Pages: 11-18, ISSN: 0302-9743
© 2017, Springer International Publishing AG. Intraoperative ultrasound is an imaging modality frequently used to provide delineation of tissue boundaries. This paper proposes a simulation platform that enables rehearsal of patient-specific deformable ultrasound scanning in real-time, using preoperative CT as the data source. The simulation platform was implemented within the GPU-accelerated NVIDIA FleX position-based dynamics framework. The high-resolution particle model is used to deform both surface and volume meshes. The latter is used to compute the barycentric coordinates of each simulated ultrasound image pixel in the surrounding volume, which is then mapped back to the original undeformed CT volume. To validate the computation of simulated ultrasound images, a kidney phantom with an embedded tumour was CT-scanned in the rest position and at five different levels of probe-induced deformation. Measures of normalised cross-correlation and similarity between features were adopted to compare pairs of simulated and ground truth images. The accurate results demonstrate the potential of this approach for clinical translation.
Carter AW, Mandavia R, Mayer E, et al., 2017, Systematic review of economic analyses in patient safety: a protocol designed to measure development in the scope and quality of evidence, BMJ OPEN, Vol: 7, ISSN: 2044-6055
Flott K, Hounsome L, Vuik S, et al., 2017, A patient-centric approach to improving experience in urological cancer care, JOURNAL OF CLINICAL UROLOGY, Vol: 10, Pages: 39-46, ISSN: 2051-4158
Flott KM, Graham C, Darzi A, et al., 2017, Can we use patient-reported feedback to drive change? The challenges of using patient-reported feedback and how they might be addressed, BMJ QUALITY & SAFETY, Vol: 26, Pages: 502-507, ISSN: 2044-5415
Howell A-M, Burns EM, Hull L, et al., 2017, International recommendations for national patient safety incident reporting systems: an expert Delphi consensus-building process, BMJ QUALITY & SAFETY, Vol: 26, Pages: 150-163, ISSN: 2044-5415
Howell A-M, Burns EM, Hull L, et al., 2017, Incident reporting: rare incidents may benefit from national problem solving, BMJ QUALITY & SAFETY, Vol: 26, Pages: 517-517, ISSN: 2044-5415
Jallad S, Hounsome L, Verne J, et al., 2017, Where are we with improving outcome guidance? An update on pelvic urological services in the NHS, JOURNAL OF CLINICAL UROLOGY, Vol: 10, Pages: 29-33, ISSN: 2051-4158
Jay A, Aldiwani M, Wijayarathna S, et al., 2017, THE FEATURES AND MANAGEMENT OF LATE RELAPSE OF NON-SEMINOMATOUS GERM CELL TUMOURS, Annual Meeting of the American-Urological-Association (AUA), Publisher: ELSEVIER SCIENCE INC, Pages: E1041-E1041, ISSN: 0022-5347
Kockelbergh R, Hounsome L, Mayer E, 2017, The Epidemiology of urological cancer 2001-2013, JOURNAL OF CLINICAL UROLOGY, Vol: 10, Pages: 3-8, ISSN: 2051-4158
Omar I, Dilley J, Pucher P, et al., 2017, THE ROBOTIX SIMULATOR: FACE AND CONTENT VALIDATION USING THE FUNDAMENTALS OF ROBOTIC SURGERY(FRS)CURRICULUM, Annual Meeting of the American-Urological-Association (AUA), Publisher: ELSEVIER SCIENCE INC, Pages: E700-E701, ISSN: 0022-5347
Vuik SI, Fontana G, Mayer E, et al., 2017, Do hospitalisations for ambulatory care sensitive conditions reflect low access to primary care? An observational cohort study of primary care usage prior to hospitalisation., BMJ Open, Vol: 7
OBJECTIVES: To explore whether hospitalisations for ambulatory care sensitive conditions (ACSCs) are associated with low access to primary care. DESIGN: Observational cohort study over 2008 to 2012 using the Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES) databases. SETTING: English primary and secondary care. PARTICIPANTS: A random sample of 300 000 patients. MAIN OUTCOME MEASURES: Emergency hospitalisation for an ACSC. RESULTS: Over the long term, patients with ACSC hospitalisations had on average 2.33 (2.17 to 2.49) more general practice contacts per 6 months than patients with similar conditions who did not require hospitalisation. When accounting for the number of diagnosed ACSCs, age, gender and GP practice through a nested case-control method, the difference was smaller (0.64 contacts), but still significant (p<0.001).In the short-term analysis, measured over the 6 months prior to hospitalisation, patients used more GP services than on average over the 5 years. Cases had significantly (p<0.001) more primary care contacts in the 6 months before ACSC hospitalisations (7.12, 95% CI 6.95 to 7.30) than their controls during the same 6 months (5.57, 95% CI 5.43 to 5.72). The use of GP services increased closer to the time of hospitalisation, with a peak of 1.79 (1.74 to 1.83) contacts in the last 30 days before hospitalisation. CONCLUSIONS: This study found no evidence to support the hypothesis that low access to primary care is the main driver of ACSC hospitalisations. Other causes should also be explored to understand how to use ACSC admission rates as quality metrics, and to develop the appropriate interventions.
Camara M, Mayer E, Darzi A, et al., 2016, Soft tissue deformation for surgical simulation: a position-based dynamics approach, INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, Vol: 11, Pages: 919-928, ISSN: 1861-6410
Flott K, Callahan R, Darzi A, et al., 2016, A Patient-Centered Framework for Evaluating Digital Maturity of Health Services: A Systematic Review, JOURNAL OF MEDICAL INTERNET RESEARCH, Vol: 18, Pages: 153-162, ISSN: 1438-8871
Flott K, Callahan R, Darzi A, et al., 2016, A Patient-Centered Framework for Evaluating Digital Maturity of Health Services: A Systematic Review, JOURNAL OF MEDICAL INTERNET RESEARCH, Vol: 18, ISSN: 1438-8871
Flott K, Darzi A, Mayer E, 2016, EVALUATION FRAMEWORK FOR PATIENT SAFETY INCIDENT REPORTING SYSTEMS, INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE, Vol: 28, Pages: 8-9, ISSN: 1353-4505
Hughes-Hallett A, Browne D, Mensah E, et al., 2016, Assessing the impact of mass media public health campaigns. Be Clear on Cancer 'blood in pee': a case in point, BJU INTERNATIONAL, Vol: 117, Pages: 570-575, ISSN: 1464-4096
Hughes-Hallett A, Pratt P, Mayer E, et al., 2016, Using preoperative imaging for intraoperative guidance: a case of mistaken identity, INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY, Vol: 12, Pages: 262-267, ISSN: 1478-5951
Mason SE, Scott AJ, Mayer E, et al., 2016, Patient-related risk factors for urinary retention following ambulatory general surgery: a systematic review and meta-analysis, AMERICAN JOURNAL OF SURGERY, Vol: 211, Pages: 1126-1134, ISSN: 0002-9610
Mayer E, Darzi A, 2016, Innovation and surgical clinical trials, LANCET, Vol: 388, Pages: 1027-1028, ISSN: 0140-6736
Mayer E, Flott K, Callahan RP, et al., 2016, National Reporting and Learning System Research and Development
This report presents the findings of the NRLS Researchand Development Programme conducted by thePatient Safety Translational Research Centre (PSTRC)and the Centre for Health Policy (CHP) at ImperialCollege London.It sets out the current state of affairs regardingpatient safety incident reporting in the NHS, andspecifies where the most pressing areas of concerns are,including thorough descriptions of the various incidentreporting systems used in the NHS today. Furthermore itidentifies areas for improvement in the overall landscapeof incident reporting, and suggests how systems like theNRLS can capitalise on developments in technology.The main body of the report is then devoted toexplaining the findings from the research programme. Theresearch was divided into four domains, and the reportdetails the new findings discovered about each of them:1. Purpose of incident reporting in healthcare2. User experience with reporting systems3. Data quality and analysis4. Effective feedback for learningBuilding on these findings, the report moves on to describehow they can be applied to the next generation ofincident reporting. Specifically, it focuses on a prototypefor a new incident reporting system that incorporates theimprovement ideas generated by the research.Finally, the report concludes with a description ofan evidence-based framework for evaluating incidentreporting systems and an ‘Achievement Toolkit’ often recommendations for improvements to incidentreporting systems.
Mensah EE, Nicol D, Mayer E, 2016, Primary testicular tumours and management of clinical stage 1 testicular cancer, JOURNAL OF CLINICAL UROLOGY, Vol: 9, Pages: 84-92, ISSN: 2051-4158
Vuik SI, Mayer E, Darzi A, 2016, Enhancing risk stratification for use in integrated care: a cluster analysis of high-risk patients in a retrospective cohort study, BMJ OPEN, Vol: 6, ISSN: 2044-6055
Vuik SI, Mayer E, Darzi A, 2016, A quantitative evidence base for population health: applying utilization-based cluster analysis to segment a patient population, POPULATION HEALTH METRICS, Vol: 14, ISSN: 1478-7954
Vuik SI, Mayer E, Darzi A, 2016, Understanding population health needs: How data-driven population segmentation can support the planning of integrated care, Publisher: UBIQUITY PRESS LTD, ISSN: 1568-4156
Vuik SI, Mayer EK, Darzi A, 2016, Patient Segmentation Analysis Offers Significant Benefits For Integrated Care And Support, HEALTH AFFAIRS, Vol: 35, Pages: 769-775, ISSN: 0278-2715
Cooper CS, Eeles R, Wedge DC, et al., 2015, Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue (vol 47, pg 367, 2015), NATURE GENETICS, Vol: 47, Pages: 689-689, ISSN: 1061-4036
Cooper CS, Eeles R, Wedge DC, et al., 2015, Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue, NATURE GENETICS, Vol: 47, Pages: 367-U118, ISSN: 1061-4036
Cooper CS, Eeles R, Wedge DC, et al., 2015, Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue., Nat Genet, Vol: 47
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