Imperial College London
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Erik Mayer

Faculty of Medicine, Department of Surgery & Cancer

Clinical Reader in Urology
 
 
 
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Contact

 

e.mayer Website

 
 
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Location

 

1020Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cooper:2015:10.1038/ng.3221,
author = {Cooper, CS and Eeles, R and Wedge, DC and Van, Loo P and Gundem, G and Alexandrov, LB and Kremeyer, B and Butler, A and Lynch, AG and Camacho, N and Massie, CE and Kay, J and Luxton, HJ and Edwards, S and Kote-Jarai, Z and Dennis, N and Merson, S and Leongamornlert, D and Zamora, J and Corbishley, C and Thomas, S and Nik-Zainal, S and Ramakrishna, M and O'Meara, S and Matthews, L and Clark, J and Hurst, R and Mithen, R and Bristow, RG and Boutros, PC and Fraser, M and Cooke, S and Raine, K and Jones, D and Menzies, A and Stebbings, L and Hinton, J and Teague, J and McLaren, S and Mudie, L and Hardy, C and Anderson, E and Joseph, O and Goody, V and Robinson, B and Maddison, M and Gamble, S and Greenman, C and Berney, D and Hazell, S and Livni, N and ICGC, Prostate Group and Fisher, C and Ogden, C and Kumar, P and Thompson, A and Woodhouse, C and Nicol, D and Mayer, E and Dudderidge, T and Shah, NC and Gnanapragasam, V and Voet, T and Campbell, P and Futreal, A and Easton, D and Warren, },
doi = {10.1038/ng.3221},
journal = {Nature Genetics},
pages = {367--372},
title = {Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.},
url = {http://dx.doi.org/10.1038/ng.3221},
volume = {47},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work in morphologically normal tissue were also at work in cancer. Our observations demonstrate the existence of ongoing abnormal mutational processes, consistent with field effects, underlying carcinogenesis. This mechanism gives rise to extensive branching evolution and cancer clone mixing, as exemplified by the coexistence of multiple cancer lineages harboring distinct ERG fusions within a single cancer nodule. Subsets of mutations were shared either by morphologically normal and malignant tissues or between different ERG lineages, indicating earlier or separate clonal cell expansions. Our observations inform on the origin of multifocal disease and have implications for prostate cancer therapy in individual cases.
AU  - Cooper,CS
AU  - Eeles,R
AU  - Wedge,DC
AU  - Van,Loo P
AU  - Gundem,G
AU  - Alexandrov,LB
AU  - Kremeyer,B
AU  - Butler,A
AU  - Lynch,AG
AU  - Camacho,N
AU  - Massie,CE
AU  - Kay,J
AU  - Luxton,HJ
AU  - Edwards,S
AU  - Kote-Jarai,Z
AU  - Dennis,N
AU  - Merson,S
AU  - Leongamornlert,D
AU  - Zamora,J
AU  - Corbishley,C
AU  - Thomas,S
AU  - Nik-Zainal,S
AU  - Ramakrishna,M
AU  - O'Meara,S
AU  - Matthews,L
AU  - Clark,J
AU  - Hurst,R
AU  - Mithen,R
AU  - Bristow,RG
AU  - Boutros,PC
AU  - Fraser,M
AU  - Cooke,S
AU  - Raine,K
AU  - Jones,D
AU  - Menzies,A
AU  - Stebbings,L
AU  - Hinton,J
AU  - Teague,J
AU  - McLaren,S
AU  - Mudie,L
AU  - Hardy,C
AU  - Anderson,E
AU  - Joseph,O
AU  - Goody,V
AU  - Robinson,B
AU  - Maddison,M
AU  - Gamble,S
AU  - Greenman,C
AU  - Berney,D
AU  - Hazell,S
AU  - Livni,N
AU  - ICGC,Prostate Group
AU  - Fisher,C
AU  - Ogden,C
AU  - Kumar,P
AU  - Thompson,A
AU  - Woodhouse,C
AU  - Nicol,D
AU  - Mayer,E
AU  - Dudderidge,T
AU  - Shah,NC
AU  - Gnanapragasam,V
AU  - Voet,T
AU  - Campbell,P
AU  - Futreal,A
AU  - Easton,D
AU  - Warren,AY
AU  - Foster,CS
AU  - Stratton,MR
AU  - Whitaker,HC
AU  - McDermott,U
AU  - Brewer,DS
AU  - Neal,DE
DO  - 10.1038/ng.3221
EP  - 372
PY  - 2015///
SN  - 1546-1718
SP  - 367
TI  - Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3221
UR  - http://hdl.handle.net/10044/1/27635
VL  - 47
ER  -
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