1025 results found
Zamora-Ros R, Beraud V, Franceschi S, et al., 2018, Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, INTERNATIONAL JOURNAL OF CANCER, Vol: 142, Pages: 449-459, ISSN: 0020-7136
Al-Dabhani K, Tsilidis KK, Murphy N, et al., 2017, Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population, NUTRITION & DIABETES, Vol: 7, ISSN: 2044-4052
Aleksandrova K, Jenab M, Leitzmann M, et al., 2017, Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 46, Pages: 1823-1835, ISSN: 0300-5771
Aleksandrova K, Schlesinger S, Fedirko V, et al., 2017, Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 185, Pages: 751-764, ISSN: 0002-9262
Ambatipudi S, Horvath S, Perrier F, et al., 2017, DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility, EUROPEAN JOURNAL OF CANCER, Vol: 75, Pages: 299-307, ISSN: 0959-8049
Aune D, Giovannucci E, Boffetta P, et al., 2017, Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 46, Pages: 1029-1056, ISSN: 0300-5771
Aune D, Sen A, Schlesinger S, et al., 2017, Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 32, Pages: 181-192, ISSN: 0393-2990
Bergmann MM, Hernandez V, Bernigau W, et al., 2017, No association of alcohol use and the risk of ulcerative colitis or Crohn's disease: data from a European Prospective cohort study (EPIC), EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 71, Pages: 512-518, ISSN: 0954-3007
Brennan P, Perola M, van Ommen G-J, et al., 2017, Chronic disease research in Europe and the need for integrated population cohorts, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 32, Pages: 741-749, ISSN: 0393-2990
Byrne KS, Maria Castano J, Dolores Chirlaque M, et al., 2017, Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC), JOURNAL OF CLINICAL ONCOLOGY, Vol: 35, Pages: 1297-+, ISSN: 0732-183X
Chajes V, Assi N, Biessy C, et al., 2017, A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study, ANNALS OF ONCOLOGY, Vol: 28, Pages: 2836-2842, ISSN: 0923-7534
Dossus L, Franceschi S, Biessy C, et al., 2017, Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study., Int J Cancer
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49-0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67-2.76, Ptrend = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13-2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80-3.98, Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
Ezzati M, Bentham J, Di Cesare M, et al., 2017, Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults, LANCET, Vol: 390, Pages: 2627-2642, ISSN: 0140-6736
Fedirko V, Hao QT, Gewirtz AT, et al., 2017, Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study, BMC MEDICINE, Vol: 15, ISSN: 1741-7015
Fehringer G, Brenner DR, Zhang Z-F, et al., 2017, Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1976-1984, ISSN: 0020-7136
Fortner RT, Huesing A, Kuehn T, et al., 2017, Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1317-1323, ISSN: 0020-7136
Fortner RT, Sarink D, Schock H, et al., 2017, Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort, BMC MEDICINE, Vol: 15, ISSN: 1741-7015
Fortner RT, Schock H, Le Cornet C, et al., 2017, Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort., Int J Cancer
CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; phet = 0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection.
Fortner RT, Vitonis AF, Schock H, et al., 2017, Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort, JOURNAL OF OVARIAN RESEARCH, Vol: 10, ISSN: 1757-2215
Gu F, Zhang H, Hyland P, et al., 2017, 0031 INHERITED VARIATION IN CIRCADIAN RHYTHM GENES AND RISKS OF PROSTATE CANCER AND THREE OTHER CANCER SITES IN COMBINED CANCER CONSORTIA, Sleep, Vol: 40, Pages: A12-A12, ISSN: 0161-8105
Gunter MJ, Murphy N, Cross AJ, et al., 2017, Coffee Drinking and Mortality in 10 European Countries A Multinational Cohort Study, ANNALS OF INTERNAL MEDICINE, Vol: 167, Pages: 236-+, ISSN: 0003-4819
Hendricks AE, Bochukova EG, Marenne G, et al., 2017, Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity., Sci Rep, Vol: 7
Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as described previously. Nominally significant associations were found for rare functional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and ANGPTL6. The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF~0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells. Further analysis including additional case-control studies and population controls (N = 260,642) did not support association of this variant with obesity (odds ratio = 2.34, p-value = 2.59 × 10-3), highlighting the challenges of testing rare variant associations and the need for very large sample sizes. Further validation in cohorts with severe obesity and engineering the variants in model organisms will be needed to explore whether human variants in ANGPTL6 and other genes that lead to obesity when deleted in mice, do contribute to obesity. Such studies may yield druggable targets for weight loss therapies.
Huang J, Zagai U, Hallmans G, et al., 2017, Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1727-1735, ISSN: 0020-7136
Huesing A, Fortner RT, Kuehn T, et al., 2017, Added Value of Serum Hormone Measurements in Risk Prediction Models for Breast Cancer for Women Not Using Exogenous Hormones: Results from the EPIC Cohort, CLINICAL CANCER RESEARCH, Vol: 23, Pages: 4181-4189, ISSN: 1078-0432
Hughes D, Fedirko V, Meplan C, et al., 2017, SELENIUM PATHWAY GENOTYPES ARE ASSOCIATED WITH COLORECTAL CANCER RISK AND MODIFIED BY SELENIUM STATUS, Publisher: KARGER, Pages: 1132-1133, ISSN: 0250-6807
Imamura F, Sharp SJ, Koulman A, et al., 2017, A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study, PLOS MEDICINE, Vol: 14, ISSN: 1549-1676
Jay R, Brennan P, Brenner, et al., 2017, Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559., Urol Oncol, Vol: 35
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
Lassale C, Tzoulaki I, Moons KGM, et al., 2017, Separate and combined associations of obesity and metabolic health with coronary heart disease:a pan-European case-cohort analysis, European Heart Journal, ISSN: 1522-9645
AimsThe hypothesis of ‘metabolically healthy obesity’ implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk. We tested this hypothesis in a large pan-European prospective study.Methods and resultsWe conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study (‘EPIC-CVD’). During a median follow-up of 12.2 years, we recorded 7637 incident coronary heart disease (CHD) cases. Using cut-offs recommended by guidelines, we defined obesity and overweight using body mass index (BMI), and metabolic dysfunction (‘unhealthy’) as ≥ 3 of elevated blood pressure, hypertriglyceridaemia, low HDL-cholesterol, hyperglycaemia, and elevated waist circumference. We calculated hazard ratios (HRs) and 95% confidence intervals (95% CI) within each country using Prentice-weighted Cox proportional hazard regressions, accounting for age, sex, centre, education, smoking, diet, and physical activity. Compared with metabolically healthy normal weight people (reference), HRs were 2.15 (95% CI: 1.79; 2.57) for unhealthy normal weight, 2.33 (1.97; 2.76) for unhealthy overweight, and 2.54 (2.21; 2.92) for unhealthy obese people. Compared with the reference group, HRs were 1.26 (1.14; 1.40) and 1.28 (1.03; 1.58) for metabolically healthy overweight and obese people, respectively. These results were robust to various sensitivity analyses.ConclusionIrrespective of BMI, metabolically unhealthy individuals had higher CHD risk than their healthy counterparts. Conversely, irrespective of metabolic health, overweight and obese people had higher CHD risk than lean people. These findings challenge the concept of ‘metabolically healthy obesity’, encouraging population-wide strategies to tackle obesity.
Law PJ, Berndt SI, Speedy HE, et al., 2017, Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723
Li SX, Imamura F, Ye Z, et al., 2017, Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 106, Pages: 263-275, ISSN: 0002-9165
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