1010 results found
Merritt MA, Tzoulaki I, van den Brandt PA, et al., Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the EPIC study and the NLCS, American Journal of Clinical Nutrition, ISSN: 1938-3207
Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.Objective: We used a ‘nutrient-wide association study’ approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing using the false discovery rate (FDR) and evaluated the findings in an independent cohort.Design: We assessed dietary intake levels of 28 foods/food groups and 29 nutrients estimated using dietary questionnaires in the European Prospective Investigation into Cancer and Nutrition (EPIC; N=1095 cases). We selected four foods/nutrients that were significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (FDR=0.43), and evaluated these factors in the Netherlands Cohort Study (NLCS; N=383 cases). Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: None of the four dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, bananas) were significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high versus low intake of saturated fat (Q4 versus Q1, overall HR, 1.21; 95% CI, 1.04, 1.41).Conclusions: In the meta-analysis of both studies there was a higher risk of EOC with a high versus low intake of saturated fat.
van Duijnhoven FJB, Jenab M, Hveem K, et al., Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations, International Journal of Cancer, ISSN: 0020-7136
Al-Dabhani K, Tsilidis KK, Murphy N, et al., 2017, Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population, NUTRITION & DIABETES, Vol: 7, ISSN: 2044-4052
Aleksandrova K, Jenab M, Leitzmann M, et al., 2017, Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort., Int J Epidemiol
Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. Results: High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs <91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively. Conclusions: Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.
Aleksandrova K, Schlesinger S, Fedirko V, et al., 2017, Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 185, Pages: 751-764, ISSN: 0002-9262
Ambatipudi S, Horvath S, Perrier F, et al., 2017, DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility, EUROPEAN JOURNAL OF CANCER, Vol: 75, Pages: 299-307, ISSN: 0959-8049
Aune D, Giovannucci E, Boffetta P, et al., 2017, Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 46, Pages: 1029-1056, ISSN: 0300-5771
Aune D, Sen A, Schlesinger S, et al., 2017, Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 32, Pages: 181-192, ISSN: 0393-2990
Bergmann MM, Hernandez V, Bernigau W, et al., 2017, No association of alcohol use and the risk of ulcerative colitis or Crohn's disease: data from a European Prospective cohort study (EPIC), EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 71, Pages: 512-518, ISSN: 0954-3007
Brennan P, Perola M, van Ommen G-J, et al., 2017, Chronic disease research in Europe and the need for integrated population cohorts., Eur J Epidemiol
Byrne KS, Maria Castano J, Dolores Chirlaque M, et al., 2017, Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC), JOURNAL OF CLINICAL ONCOLOGY, Vol: 35, Pages: 1297-+, ISSN: 0732-183X
Chajès V, Assi N, Biessy C, et al., 2017, A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study., Ann Oncol
Background: Intakes of specific fatty acids have been postulated to impact breast cancer risk but epidemiological data based on dietary questionnaires remain conflicting. Material and methods: We assessed the association between plasma phospholipid fatty acids and breast cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Sixty fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 2,982 incident breast cancer cases matched to 2,982 controls. Conditional logistic regression models were used to estimate relative risk of breast cancer by fatty acid level. The false discovery rate (q-values) was computed to control for multiple comparisons. Subgroup analyses were performed by estrogen receptor (ER) and progesterone receptor (PR) expression in the tumours. Results: A high level of palmitoleic acid (odds ratio, OR for the highest quartile compared with the lowest OR[Q4-Q1]=1.37; 95%CI=1.14-1.64; p for trend=0.0001, q-value=0.004) as well as a high desaturation index (DI 16 ) (16:1n-7/16:0) (OR[Q4-Q1]=1.28; 95%CI=1.07-1.54; p for trend=0.002, q -value=0.037), as biomarkers of de novo lipogenesis, were significantly associated with increased risk of breast cancer. Levels of industrial trans-fatty acids were positively associated with ER-negative tumors (OR for the highest tertile compared with the lowest [T3-T1]=2.01; 95% CI = 1.03-3.90; p for trend=0.047), while no association was found for ER-positive tumors ( P -heterogeneity =0.01). No significant association was found between n-3 polyunsaturated fatty acids and breast cancer risk, overall or by hormonal receptor. Conclusion: These findings suggest that increased de novo lipogenesis, acting through increased synthesis of palmitoleic acid, could be a relevant metabolic pathway for breast tumorigenesis. Dietary trans fatty acids derived from industrial processes may specifically increase ER-nega
Fedirko V, Hao QT, Gewirtz AT, et al., 2017, Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study, BMC MEDICINE, Vol: 15, ISSN: 1741-7015
Fehringer G, Brenner DR, Zhang Z-F, et al., 2017, Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1976-1984, ISSN: 0020-7136
Fortner RT, Huesing A, Kuehn T, et al., 2017, Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1317-1323, ISSN: 0020-7136
Fortner RT, Sarink D, Schock H, et al., 2017, Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort, BMC MEDICINE, Vol: 15, ISSN: 1741-7015
Fortner RT, Vitonis AF, Schock H, et al., 2017, Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort, JOURNAL OF OVARIAN RESEARCH, Vol: 10, ISSN: 1757-2215
Gu F, Zhang H, Hyland PL, et al., 2017, 0031 INHERITED VARIATION IN CIRCADIAN RHYTHM GENES AND RISKS OF PROSTATE CANCER AND THREE OTHER CANCER SITES IN COMBINED CANCER CONSORTIA, Sleep, Vol: 40, Pages: A12-A12, ISSN: 0161-8105
Gunter MJ, Murphy N, Cross AJ, et al., 2017, Coffee Drinking and Mortality in 10 European Countries A Multinational Cohort Study, ANNALS OF INTERNAL MEDICINE, Vol: 167, Pages: 236-+, ISSN: 0003-4819
Hendricks AE, Bochukova EG, Marenne G, et al., 2017, Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity., Sci Rep, Vol: 7
Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as described previously. Nominally significant associations were found for rare functional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and ANGPTL6. The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF~0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells. Further analysis including additional case-control studies and population controls (N = 260,642) did not support association of this variant with obesity (odds ratio = 2.34, p-value = 2.59 × 10(-3)), highlighting the challenges of testing rare variant associations and the need for very large sample sizes. Further validation in cohorts with severe obesity and engineering the variants in model organisms will be needed to explore whether human variants in ANGPTL6 and other genes that lead to obesity when deleted in mice, do contribute to obesity. Such studies may yield druggable targets for weight loss therapies.
Huang J, Zagai U, Hallmans G, et al., 2017, Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1727-1735, ISSN: 0020-7136
Huesing A, Fortner RT, Kuehn T, et al., 2017, Added Value of Serum Hormone Measurements in Risk Prediction Models for Breast Cancer for Women Not Using Exogenous Hormones: Results from the EPIC Cohort, CLINICAL CANCER RESEARCH, Vol: 23, Pages: 4181-4189, ISSN: 1078-0432
Imamura F, Sharp SJ, Koulman A, et al., 2017, A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study., PLoS Med, Vol: 14
BACKGROUND: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. METHODS AND FINDINGS: We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested case-cohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of γ-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p <
Jay R, Brennan P, Brenner, et al., 2017, Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559., Urol Oncol, Vol: 35
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
Lassale C, Tzoulaki I, Moons KGM, et al., 2017, Separate and combined associations of obesity and metabolic health with coronary heart disease:a pan-European case-cohort analysis, European Heart Journal, ISSN: 1522-9645
AimsThe hypothesis of ‘metabolically healthy obesity’ implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk. We tested this hypothesis in a large pan-European prospective study.Methods and resultsWe conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study (‘EPIC-CVD’). During a median follow-up of 12.2 years, we recorded 7637 incident coronary heart disease (CHD) cases. Using cut-offs recommended by guidelines, we defined obesity and overweight using body mass index (BMI), and metabolic dysfunction (‘unhealthy’) as ≥ 3 of elevated blood pressure, hypertriglyceridaemia, low HDL-cholesterol, hyperglycaemia, and elevated waist circumference. We calculated hazard ratios (HRs) and 95% confidence intervals (95% CI) within each country using Prentice-weighted Cox proportional hazard regressions, accounting for age, sex, centre, education, smoking, diet, and physical activity. Compared with metabolically healthy normal weight people (reference), HRs were 2.15 (95% CI: 1.79; 2.57) for unhealthy normal weight, 2.33 (1.97; 2.76) for unhealthy overweight, and 2.54 (2.21; 2.92) for unhealthy obese people. Compared with the reference group, HRs were 1.26 (1.14; 1.40) and 1.28 (1.03; 1.58) for metabolically healthy overweight and obese people, respectively. These results were robust to various sensitivity analyses.ConclusionIrrespective of BMI, metabolically unhealthy individuals had higher CHD risk than their healthy counterparts. Conversely, irrespective of metabolic health, overweight and obese people had higher CHD risk than lean people. These findings challenge the concept of ‘metabolically healthy obesity’, encouraging population-wide strategies to tackle obesity.
Law PJ, Berndt SI, Speedy HE, et al., 2017, Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723
Li SX, Imamura F, Ye Z, et al., 2017, Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 106, Pages: 263-275, ISSN: 0002-9165
Lu Y, Zamora-Ros R, Chan S, et al., 2017, Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)., Inflamm Bowel Dis
BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC. RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance. CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
Matejcic M, de Batlle J, Ricci C, et al., 2017, Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1246-1259, ISSN: 0020-7136
Molina-Montes E, Sanchez M-J, Buckland G, et al., 2017, Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort, BRITISH JOURNAL OF CANCER, Vol: 116, Pages: 811-820, ISSN: 0007-0920
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