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@article{Dadaev:2018:10.1038/s41467-018-04109-8,
author = {Dadaev, T and Saunders, EJ and Newcombe, PJ and Anokian, E and Leongamornlert, DA and Brook, MN and Cieza-Borrella, C and Mijuskovic, M and Wakerell, S and Olama, AAA and Schumacher, FR and Berndt, SI and Benlloch, S and Ahmed, M and Goh, C and Sheng, X and Zhang, Z and Muir, K and Govindasami, K and Lophatananon, A and Stevens, VL and Gapstur, SM and Carter, BD and Tangen, CM and Goodman, P and Thompson, IM and Batra, J and Chambers, S and Moya, L and Clements, J and Horvath, L and Tilley, W and Risbridger, G and Gronberg, H and Aly, M and Nordström, T and Pharoah, P and Pashayan, N and Schleutker, J and Tammela, TLJ and Sipeky, C and Auvinen, A and Albanes, D and Weinstein, S and Wolk, A and Hakansson, N and West, C and Dunning, AM and Burnet, N and Mucci, L and Giovannucci, E and Andriole, G and Cussenot, O and Cancel-Tassin, G and Koutros, S and Freeman, LEB and Sorensen, KD and Orntoft, TF and Borre, M and Maehle, L and Grindedal, EM and Neal, DE and Donovan, JL and Hamdy, FC and },
doi = {10.1038/s41467-018-04109-8},
journal = {Nature Communications},
title = {Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.},
url = {http://dx.doi.org/10.1038/s41467-018-04109-8},
volume = {9},
year = {2018}
}

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TY  - JOUR
AB  - Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
AU  - Dadaev,T
AU  - Saunders,EJ
AU  - Newcombe,PJ
AU  - Anokian,E
AU  - Leongamornlert,DA
AU  - Brook,MN
AU  - Cieza-Borrella,C
AU  - Mijuskovic,M
AU  - Wakerell,S
AU  - Olama,AAA
AU  - Schumacher,FR
AU  - Berndt,SI
AU  - Benlloch,S
AU  - Ahmed,M
AU  - Goh,C
AU  - Sheng,X
AU  - Zhang,Z
AU  - Muir,K
AU  - Govindasami,K
AU  - Lophatananon,A
AU  - Stevens,VL
AU  - Gapstur,SM
AU  - Carter,BD
AU  - Tangen,CM
AU  - Goodman,P
AU  - Thompson,IM
AU  - Batra,J
AU  - Chambers,S
AU  - Moya,L
AU  - Clements,J
AU  - Horvath,L
AU  - Tilley,W
AU  - Risbridger,G
AU  - Gronberg,H
AU  - Aly,M
AU  - Nordström,T
AU  - Pharoah,P
AU  - Pashayan,N
AU  - Schleutker,J
AU  - Tammela,TLJ
AU  - Sipeky,C
AU  - Auvinen,A
AU  - Albanes,D
AU  - Weinstein,S
AU  - Wolk,A
AU  - Hakansson,N
AU  - West,C
AU  - Dunning,AM
AU  - Burnet,N
AU  - Mucci,L
AU  - Giovannucci,E
AU  - Andriole,G
AU  - Cussenot,O
AU  - Cancel-Tassin,G
AU  - Koutros,S
AU  - Freeman,LEB
AU  - Sorensen,KD
AU  - Orntoft,TF
AU  - Borre,M
AU  - Maehle,L
AU  - Grindedal,EM
AU  - Neal,DE
AU  - Donovan,JL
AU  - Hamdy,FC
AU  - Martin,RM
AU  - Travis,RC
AU  - Key,TJ
AU  - Hamilton,RJ
AU  - Fleshner,NE
AU  - Finelli,A
AU  - Ingles,SA
AU  - Stern,MC
AU  - Rosenstein,B
AU  - Kerns,S
AU  - Ostrer,H
AU  - Lu,Y-J
AU  - Zhang,H-W
AU  - Feng,N
AU  - Mao,X
AU  - Guo,X
AU  - Wang,G
AU  - Sun,Z
AU  - Giles,GG
AU  - Southey,MC
AU  - MacInnis,RJ
AU  - FitzGerald,LM
AU  - Kibel,AS
AU  - Drake,BF
AU  - Vega,A
AU  - Gómez-Caamaño,A
AU  - Fachal,L
AU  - Szulkin,R
AU  - Eklund,M
AU  - Kogevinas,M
AU  - Llorca,J
AU  - Castaño-Vinyals,G
AU  - Penney,KL
AU  - Stampfer,M
AU  - Park,JY
AU  - Sellers,TA
AU  - Lin,H-Y
AU  - Stanford,JL
AU  - Cybulski,C
AU  - Wokolorczyk,D
AU  - Lubinski,J
AU  - Ostrander,EA
AU  - Geybels,MS
AU  - Nordestgaard,BG
AU  - Nielsen,SF
AU  - Weisher,M
AU  - Bisbjerg,R
AU  - Røder,MA
AU  - Iversen,P
AU  - Brenner,H
AU  - Cuk,K
AU  - Holleczek,B
AU  - Maier,C
AU  - Luedeke,M
AU  - Schnoeller,T
AU  - Kim,J
AU  - Logothetis,CJ
AU  - John,EM
AU  - Teixeira,MR
AU  - Paulo,P
AU  - Cardoso,M
AU  - Neuhausen,SL
AU  - Steele,L
AU  - Ding,YC
AU  - De,Ruyck K
AU  - De,Meerleer G
AU  - Ost,P
AU  - Razack,A
AU  - Lim,J
AU  - Teo,S-H
AU  - Lin,DW
AU  - Newcomb,LF
AU  - Lessel,D
AU  - Gamulin,M
AU  - Kulis,T
AU  - Kaneva,R
AU  - Usmani,N
AU  - Slavov,C
AU  - Mitev,V
AU  - Parliament,M
AU  - Singhal,S
AU  - Claessens,F
AU  - Joniau,S
AU  - Van,den Broeck T
AU  - Larkin,S
AU  - Townsend,PA
AU  - Aukim-Hastie,C
AU  - Gago-Dominguez,M
AU  - Castelao,JE
AU  - Martinez,ME
AU  - Roobol,MJ
AU  - Jenster,G
AU  - van,Schaik RHN
AU  - Menegaux,F
AU  - Truong,T
AU  - Koudou,YA
AU  - Xu,J
AU  - Khaw,K-T
AU  - Cannon-Albright,L
AU  - Pandha,H
AU  - Michael,A
AU  - Kierzek,A
AU  - Thibodeau,SN
AU  - McDonnell,SK
AU  - Schaid,DJ
AU  - Lindstrom,S
AU  - Turman,C
AU  - Ma,J
AU  - Hunter,DJ
AU  - Riboli,E
AU  - Siddiq,A
AU  - Canzian,F
DO  - 10.1038/s41467-018-04109-8
PY  - 2018///
SN  - 2041-1723
TI  - Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-018-04109-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29892050
UR  - http://hdl.handle.net/10044/1/60261
VL  - 9
ER  -

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