Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2018:10.1177/2047487318780435,
author = {Aune, D and Schlesinger, S and Norat, T and Riboli, E},
doi = {10.1177/2047487318780435},
journal = {European Journal of Preventive Cardiology},
pages = {1437--1451},
title = {Tobacco smoking and the risk of atrial fibrillation: a systematic review and meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1177/2047487318780435},
volume = {25},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Epidemiological studies on smoking and atrial fibrillation have been inconsistent, with some studies showing a positive association while others have found no association. It is also unclear whether there is a dose-response relationship between the number of cigarettes smoked or pack-years and the risk of atrial fibrillation. We conducted a systematic review and meta-analysis to clarify the association. Design Systematic review and meta-analysis. Methods We searched the PubMed and Embase databases for studies of smoking and atrial fibrillation up to 20 July 2017. Prospective studies and nested case-control studies within cohort studies reporting adjusted relative risk estimates and 95% confidence intervals (CIs) of atrial fibrillation associated with smoking were included. Summary relative risks (95% CIs) were estimated using a random effects model. Results Twenty nine prospective studies (22 publications) were included. The summary relative risk was 1.32 (95% CI 1.12-1.56, I2 = 84%, n = 11 studies) for current smokers, 1.09 (95% CI 1.00-1.18, I2 = 33%, n = 9) for former smokers and 1.21 (95% CI 1.12-1.31, I2 = 80%, n = 14) for ever smokers compared to never smokers. Comparing current versus non-current smokers the summary relative risk was 1.33 (95% CI 1.14-1.56, I2 = 78%, n = 10). The summary relative risk was 1.14 (95% CI 1.10-1.20, I2 = 0%, n = 3) per 10 cigarettes per day and 1.16 (95% CI 1.09-1.25, I2 = 49%, n = 2) per 10 pack-years and there was no evidence of a non-linear association for cigarettes per day, Pnon-linearity = 0.17. Conclusions The current meta-analysis suggests that smoking is associated with an increased risk of atrial fibrillation in a dose-dependent matter, but the association is weaker among former smokers compared to current smokers.
AU  - Aune,D
AU  - Schlesinger,S
AU  - Norat,T
AU  - Riboli,E
DO  - 10.1177/2047487318780435
EP  - 1451
PY  - 2018///
SN  - 2047-4873
SP  - 1437
TI  - Tobacco smoking and the risk of atrial fibrillation: a systematic review and meta-analysis of prospective studies
T2  - European Journal of Preventive Cardiology
UR  - http://dx.doi.org/10.1177/2047487318780435
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29996680
UR  - https://journals.sagepub.com/doi/metrics/10.1177/2047487318780435
UR  - http://hdl.handle.net/10044/1/61276
VL  - 25
ER  -
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