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@article{Solans:2019:10.1002/ijc.32091,
author = {Solans, M and Benavente, Y and Saez, M and Agudo, A and Naudin, S and Hosnijeh, FS and Noh, H and Freisling, H and Ferrari, P and Besson, C and Mahamat-Saleh, Y and Boutron-Ruault, M-C and Kühn, T and Kaaks, R and Boeing, H and Lasheras, C and Rodríguez-Barranco, M and Amiano, P and Huerta, JM and Barricarte, A and Schmidt, JA and Vineis, P and Riboli, E and Trichopoulou, A and Bamia, C and Peppa, E and Masala, G and Agnoli, C and Tumino, R and Sacerdote, C and Panico, S and Skeie, G and Weiderpass, E and Jerkeman, M and Ericson, U and Späth, F and Nilsson, LM and Dahm, CC and Overvad, K and Bolvig, AK and Tjønneland, A and de, Sanjose S and Buckland, G and Vermeulen, R and Nieters, A and Casabonne, D},
doi = {10.1002/ijc.32091},
journal = {International Journal of Cancer},
pages = {122--131},
title = {Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition.},
url = {http://dx.doi.org/10.1002/ijc.32091},
volume = {145},
year = {2019}
}

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TY  - JOUR
AB  - There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.
AU  - Solans,M
AU  - Benavente,Y
AU  - Saez,M
AU  - Agudo,A
AU  - Naudin,S
AU  - Hosnijeh,FS
AU  - Noh,H
AU  - Freisling,H
AU  - Ferrari,P
AU  - Besson,C
AU  - Mahamat-Saleh,Y
AU  - Boutron-Ruault,M-C
AU  - Kühn,T
AU  - Kaaks,R
AU  - Boeing,H
AU  - Lasheras,C
AU  - Rodríguez-Barranco,M
AU  - Amiano,P
AU  - Huerta,JM
AU  - Barricarte,A
AU  - Schmidt,JA
AU  - Vineis,P
AU  - Riboli,E
AU  - Trichopoulou,A
AU  - Bamia,C
AU  - Peppa,E
AU  - Masala,G
AU  - Agnoli,C
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Panico,S
AU  - Skeie,G
AU  - Weiderpass,E
AU  - Jerkeman,M
AU  - Ericson,U
AU  - Späth,F
AU  - Nilsson,LM
AU  - Dahm,CC
AU  - Overvad,K
AU  - Bolvig,AK
AU  - Tjønneland,A
AU  - de,Sanjose S
AU  - Buckland,G
AU  - Vermeulen,R
AU  - Nieters,A
AU  - Casabonne,D
DO  - 10.1002/ijc.32091
EP  - 131
PY  - 2019///
SN  - 0020-7136
SP  - 122
TI  - Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition.
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.32091
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30588620
UR  - http://hdl.handle.net/10044/1/66491
VL  - 145
ER  -

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