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@article{Vrieling:2019:10.1002/ijc.32165,
author = {Vrieling, A and Bueno-De-Mesquita, HB and Ros, MM and Kampman, E and Aben, KK and Büchner, FL and Jansen, EH and Roswall, N and Tjønneland, A and Boutron-Ruault, M-C and Cadeau, C and Chang-Claude, J and Kaaks, R and Weikert, S and Boeing, H and Trichopoulou, A and Lagiou, P and Trichopoulos, D and Sieri, S and Palli, D and Panico, S and Peeters, PH and Weiderpass, E and Skeie, G and Jakszyn, P and Chirlaque, M-D and Ardanaz, E and Sánchez, M-J and Ehrnström, R and Malm, J and Ljungberg, B and Khaw, K-T and Wareham, NJ and Brennan, P and Johansson, M and Riboli, E and Kiemeney, LA},
doi = {10.1002/ijc.32165},
journal = {International Journal of Cancer},
pages = {2349--2359},
title = {One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition},
url = {http://dx.doi.org/10.1002/ijc.32165},
volume = {145},
year = {2019}
}

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TY  - JOUR
AB  - Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.
AU  - Vrieling,A
AU  - Bueno-De-Mesquita,HB
AU  - Ros,MM
AU  - Kampman,E
AU  - Aben,KK
AU  - Büchner,FL
AU  - Jansen,EH
AU  - Roswall,N
AU  - Tjønneland,A
AU  - Boutron-Ruault,M-C
AU  - Cadeau,C
AU  - Chang-Claude,J
AU  - Kaaks,R
AU  - Weikert,S
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Trichopoulos,D
AU  - Sieri,S
AU  - Palli,D
AU  - Panico,S
AU  - Peeters,PH
AU  - Weiderpass,E
AU  - Skeie,G
AU  - Jakszyn,P
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Sánchez,M-J
AU  - Ehrnström,R
AU  - Malm,J
AU  - Ljungberg,B
AU  - Khaw,K-T
AU  - Wareham,NJ
AU  - Brennan,P
AU  - Johansson,M
AU  - Riboli,E
AU  - Kiemeney,LA
DO  - 10.1002/ijc.32165
EP  - 2359
PY  - 2019///
SN  - 0020-7136
SP  - 2349
TI  - One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.32165
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30694528
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32165
UR  - http://hdl.handle.net/10044/1/66963
VL  - 145
ER  -

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