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@article{Christakoudi:2020:10.1002/ijc.32576,
author = {Christakoudi, S and Kakourou, A and Markozannes, G and Tzoulaki, I and Weiderpass, E and Brennan, P and Gunter, M and Dahm, CC and Overvad, K and Olsen, A and Tjønneland, A and Boutron-Ruault, M-C and Madika, A-L and Severi, G and Katzke, V and Kühn, T and Bergmann, MM and Boeing, H and Karakatsani, A and Martimianaki, G and Thriskos, P and Masala, G and Sieri, S and Panico, S and Tumino, R and Ricceri, F and Agudo, A and Redondo-Sánchez, D and Colorado-Yohar, SM and Mokoroa, O and Melander, O and Stocks, T and Häggström, C and Harlid, S and Bueno-de-Mesquita, B and van, Gils CH and Vermeulen, RCH and Khaw, K-T and Wareham, N and Tong, TYN and Freisling, H and Johansson, M and Lennon, H and Aune, D and Riboli, E and Trichopoulos, D and Trichopoulou, A and Tsilidis, KK},
doi = {10.1002/ijc.32576},
journal = {International Journal of Cancer},
pages = {2680--2693},
title = {Blood pressure and risk of cancer in the European prospective investigation into cancer and nutrition},
url = {http://dx.doi.org/10.1002/ijc.32576},
volume = {146},
year = {2020}
}

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TY  - JOUR
AB  - Several studies have reported associations of hypertension with cancer, but not allresults were conclusive. We examined the association of systolic (SBP) and diastolic (DBP)blood pressure with the development of incident cancer at all anatomical sites in theEuropean Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HR)(95% confidence intervals) were estimated using multivariable Cox proportional hazardsmodels, stratified by EPIC-participating centre and age at recruitment, and adjusted for sex,education, smoking, body mass index, physical activity, diabetes and dietary (in women alsoreproductive) factors. The study included 307,318 men and women, with an average followup of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed theexpected positive association with renal cell carcinoma: HR=1.12 (1.08-1.17) per 10mmHghigher SBP and HR=1.23 (1.14-1.32) for DBP. We additionally found positive associationsfor esophageal squamous cell carcinoma (SCC): HR=1.16 (1.07-1.26) (SBP), HR=1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR=1.08 (1.04-1.12) (SBP), HR=1.09(1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, post-menopausal breast cancerand uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC, or uterineendometroid cancer. We observed weak inverse associations of SBP with cervical SCC:HR=0.91 (0.82-1.00) and lymphomas: HR=0.97 (0.93-1.00). There were no consistentassociations with cancers in other locations.Our results are largely compatible with published studies and support weak associations ofblood pressure with cancers in specific locations and morphologies.
AU  - Christakoudi,S
AU  - Kakourou,A
AU  - Markozannes,G
AU  - Tzoulaki,I
AU  - Weiderpass,E
AU  - Brennan,P
AU  - Gunter,M
AU  - Dahm,CC
AU  - Overvad,K
AU  - Olsen,A
AU  - Tjønneland,A
AU  - Boutron-Ruault,M-C
AU  - Madika,A-L
AU  - Severi,G
AU  - Katzke,V
AU  - Kühn,T
AU  - Bergmann,MM
AU  - Boeing,H
AU  - Karakatsani,A
AU  - Martimianaki,G
AU  - Thriskos,P
AU  - Masala,G
AU  - Sieri,S
AU  - Panico,S
AU  - Tumino,R
AU  - Ricceri,F
AU  - Agudo,A
AU  - Redondo-Sánchez,D
AU  - Colorado-Yohar,SM
AU  - Mokoroa,O
AU  - Melander,O
AU  - Stocks,T
AU  - Häggström,C
AU  - Harlid,S
AU  - Bueno-de-Mesquita,B
AU  - van,Gils CH
AU  - Vermeulen,RCH
AU  - Khaw,K-T
AU  - Wareham,N
AU  - Tong,TYN
AU  - Freisling,H
AU  - Johansson,M
AU  - Lennon,H
AU  - Aune,D
AU  - Riboli,E
AU  - Trichopoulos,D
AU  - Trichopoulou,A
AU  - Tsilidis,KK
DO  - 10.1002/ijc.32576
EP  - 2693
PY  - 2020///
SN  - 0020-7136
SP  - 2680
TI  - Blood pressure and risk of cancer in the European prospective investigation into cancer and nutrition
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.32576
UR  - http://hdl.handle.net/10044/1/71623
VL  - 146
ER  -

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